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MedKoo Cat#: 563687 | Name: ML402
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML402 is a selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator.

Chemical Structure

ML402
ML402
CAS#298684-44-3

Theoretical Analysis

MedKoo Cat#: 563687

Name: ML402

CAS#: 298684-44-3

Chemical Formula: C14H14ClNO2S

Exact Mass: 295.0434

Molecular Weight: 295.78

Elemental Analysis: C, 56.85; H, 4.77; Cl, 11.99; N, 4.74; O, 10.82; S, 10.84

Price and Availability

Size Price Availability Quantity
10mg USD 330.00 2 weeks
50mg USD 920.00 2 weeks
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Related CAS #
No Data
Synonym
ML402; ML-402; ML 402;
IUPAC/Chemical Name
N-[2-(4-Chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide
InChi Key
RULQUKFOBAPKKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
SMILES Code
O=C(C1=CC=CS1)NCCOC2=CC=C(Cl)C=C2C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 64.8 219.05
Ethanol 14.8 50.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 295.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL Jr. K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368. doi: 10.1038/nature22988. Epub 2017 Jul 10. PubMed PMID: 28693035; PubMed Central PMCID: PMC5778891.

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