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MedKoo Cat#: 461761 | Name: Flusilazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flusilazole is an organosilicon fungicide which is used to control fungal infections on a variety of fruit and vegetable crops. It is moderately toxic to animals and has been shown to produce birth defects and embryotoxicity at high doses.

Chemical Structure

Flusilazole
Flusilazole
CAS#85509-19-9

Theoretical Analysis

MedKoo Cat#: 461761

Name: Flusilazole

CAS#: 85509-19-9

Chemical Formula: C16H15F2N3Si

Exact Mass: 315.1003

Molecular Weight: 315.39

Elemental Analysis: C, 60.93; H, 4.79; F, 12.05; N, 13.32; Si, 8.90

Price and Availability

Size Price Availability Quantity
100mg USD 500.00 2 Weeks
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Related CAS #
No Data
Synonym
Flusilazole; Flusilazol; Fluzilazol; Nustar; Olymp; Sanction; DPX-6573; DPX6573; DPX 6573;
IUPAC/Chemical Name
1-((bis(4-fluorophenyl)(methyl)silyl)methyl)-1H-1,2,4-triazole
InChi Key
FQKUGOMFVDPBIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3
SMILES Code
C[Si](CN1N=CN=C1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 315.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang C, Qiu L, Zhao H, Wang K, Zhang H. Dissipation dynamic and residue distribution of flusilazole in mandarin. Environ Monit Assess. 2013 Nov;185(11):9169-76. doi: 10.1007/s10661-013-3244-x. Epub 2013 May 9. PubMed PMID: 23657738. 2: Ozakca DU, Silah H. Genotoxicity effects of Flusilazole on the somatic cells of Allium cepa. Pestic Biochem Physiol. 2013 Sep;107(1):38-43. doi: 10.1016/j.pestbp.2013.05.001. Epub 2013 May 10. PubMed PMID: 25149233. 3: Dimopoulou M, Verhoef A, van Ravenzwaay B, Rietjens IM, Piersma AH. Flusilazole induces spatio-temporal expression patterns of retinoic acid-, differentiation- and sterol biosynthesis-related genes in the rat Whole Embryo Culture. Reprod Toxicol. 2016 Sep;64:77-85. doi: 10.1016/j.reprotox.2016.04.003. Epub 2016 Apr 14. PubMed PMID: 27094377. 4: Yu S, Qin D, Wu Q, Guo X, Han L, Jiang S. Residue and dissipation dynamics of flusilazole in apple and soil. Bull Environ Contam Toxicol. 2011 Mar;86(3):319-22. doi: 10.1007/s00128-011-0203-5. Epub 2011 Feb 3. PubMed PMID: 21290102. 5: van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH. Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures. Toxicol Appl Pharmacol. 2011 Mar 1;251(2):110-8. doi: 10.1016/j.taap.2010.12.008. Epub 2010 Dec 28. PubMed PMID: 21192963. 6: Im SJ, Rahman MM, Abd El-Aty AM, Kim SW, Kabir H, Farha W, Lieu T, Lee YJ, Jung DI, Choi JH, Shin HC, Im GJ, Hong SM, Shim JH. Simultaneous detection of fluquinconazole and flusilazole in lettuce using gas chromatography with a nitrogen phosphorus detector: decline patterns at two different locations. Biomed Chromatogr. 2016 Jun;30(6):946-52. doi: 10.1002/bmc.3634. Epub 2015 Nov 12. PubMed PMID: 26480018. 7: Hermsen SA, Pronk TE, van den Brandhof EJ, van der Ven LT, Piersma AH. Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure. Toxicol Sci. 2012 May;127(1):303-12. doi: 10.1093/toxsci/kfs092. Epub 2012 Feb 29. PubMed PMID: 22382673. 8: Trzaskos JM, Henry MJ. Comparative effects of the azole-based fungicide flusilazole on yeast and mammalian lanosterol 14 alpha-methyl demethylase. Antimicrob Agents Chemother. 1989 Aug;33(8):1228-31. PubMed PMID: 2679371; PubMed Central PMCID: PMC172630. 9: Bensoltane S, Youbi M, Djebar H, Djebar MR. Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.). Commun Agric Appl Biol Sci. 2006;71(3 Pt B):1041-8. PubMed PMID: 17390857. 10: Anderson JJ, Shalaby LM, Berg DS. Metabolism of [(14)C]flusilazole in the goat. J Agric Food Chem. 1999 Jun;47(6):2439-46. PubMed PMID: 10794648. 11: Farag AT, Ibrahim HH. Developmental toxic effects of antifungal flusilazole administered by gavage to mice. Birth Defects Res B Dev Reprod Toxicol. 2007 Feb;80(1):12-7. PubMed PMID: 17187383. 12: Tonk EC, Pennings JL, Piersma AH. An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis. Reprod Toxicol. 2015 Aug 1;55:104-13. doi: 10.1016/j.reprotox.2014.10.008. Epub 2014 Oct 16. Review. PubMed PMID: 25461899. 13: Salunkhe VP, Sawant IS, Banerjee K, Wadkar PN, Sawant SD. Enhanced Dissipation of Triazole and Multiclass Pesticide Residues on Grapes after Foliar Application of Grapevine-Associated Bacillus Species. J Agric Food Chem. 2015 Dec 23;63(50):10736-46. doi: 10.1021/acs.jafc.5b03429. Epub 2015 Dec 11. PubMed PMID: 26492206. 14: Strong RJ, Halsall CJ, Jones KC, Shore RF, Martin FL. Infrared spectroscopy detects changes in an amphibian cell line induced by fungicides: Comparison of single and mixture effects. Aquat Toxicol. 2016 Sep;178:8-18. doi: 10.1016/j.aquatox.2016.07.005. Epub 2016 Jul 14. PubMed PMID: 27450236. 15: Zhu B, Liu L, Gong YX, Ling F, Wang GX. Triazole-induced toxicity in developing rare minnow (Gobiocypris rarus) embryos. Environ Sci Pollut Res Int. 2014 Dec;21(23):13625-35. doi: 10.1007/s11356-014-3317-6. Epub 2014 Jul 17. PubMed PMID: 25028328. 16: Egbuta C, Lo J, Ghosh D. Mechanism of inhibition of estrogen biosynthesis by azole fungicides. Endocrinology. 2014 Dec;155(12):4622-8. doi: 10.1210/en.2014-1561. Epub 2014 Sep 22. PubMed PMID: 25243857; PubMed Central PMCID: PMC4239419. 17: Wang N, Wang XC, Ma X. Characteristics of concentration-inhibition curves of individual chemicals and applicability of the concentration addition model for mixture toxicity prediction. Ecotoxicol Environ Saf. 2015 Mar;113:176-82. doi: 10.1016/j.ecoenv.2014.12.008. Epub 2014 Dec 11. PubMed PMID: 25499050. 18: Mercado DF, Bracco LLB, Arques A, Gonzalez MC, Caregnato P. Reaction kinetics and mechanisms of organosilicon fungicide flusilazole with sulfate and hydroxyl radicals. Chemosphere. 2018 Jan;190:327-336. doi: 10.1016/j.chemosphere.2017.09.134. Epub 2017 Sep 28. PubMed PMID: 28992485. 19: Konášová R, Dytrtová JJ, Kašička V. Determination of acid dissociation constants of triazole fungicides by pressure assisted capillary electrophoresis. J Chromatogr A. 2015 Aug 21;1408:243-9. doi: 10.1016/j.chroma.2015.07.005. Epub 2015 Jul 4. PubMed PMID: 26169906. 20: Menegola E, Broccia ML, Di Renzo F, Giavini E. Antifungal triazoles induce malformations in vitro. Reprod Toxicol. 2001 Jul-Aug;15(4):421-7. PubMed PMID: 11489598.

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