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MedKoo Cat#: 461758 | Name: Sdz 89-485

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SDZ 89-485 is a new orally and topically active triazole antifungal with efficacy superior to reference compounds in most animal infection models used for preclinical comparison of antifungals.

Chemical Structure

Sdz 89-485
Sdz 89-485
CAS#103183-65-9

Theoretical Analysis

MedKoo Cat#: 461758

Name: Sdz 89-485

CAS#: 103183-65-9

Chemical Formula: C16H20ClN3O

Exact Mass: 305.1295

Molecular Weight: 305.80

Elemental Analysis: C, 62.84; H, 6.59; Cl, 11.59; N, 13.74; O, 5.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sdz 89-485; San 89-485; Sandoz 89-485;
IUPAC/Chemical Name
(R)-2-(4-chlorophenyl)-3-cyclopropyl-3-methyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
InChi Key
LHDGDQZODHEIPT-INIZCTEOSA-N
InChi Code
InChI=1S/C16H20ClN3O/c1-15(2,12-3-4-12)16(21,9-20-11-18-10-19-20)13-5-7-14(17)8-6-13/h5-8,10-12,21H,3-4,9H2,1-2H3/t16-/m0/s1
SMILES Code
CC(C)(C1CC1)[C@@](O)(C2=CC=C(Cl)C=C2)CN3N=CN=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 305.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schaude M, Petranyi G, Ackerbauer H, Meingassner JG, Mieth H. Preclinical antimycotic activity of SDZ 89-485: a new orally and topically effective triazole. J Med Vet Mycol. 1990;28(6):445-54. PubMed PMID: 2093117. 2: Ryder NS. Biochemical mode of action and enantiomeric selectivity of SDZ 89-485, a new triazole antimycotic. J Med Vet Mycol. 1990;28(5):385-94. PubMed PMID: 2283585. 3: Fierer J, Kirkland T, Finley F. Comparison of fluconazole and SDZ89-485 for therapy of experimental murine coccidioidomycosis. Antimicrob Agents Chemother. 1990 Jan;34(1):13-6. PubMed PMID: 2327748; PubMed Central PMCID: PMC171511. 4: Kan VL, Bennett JE. Efficacies of four antifungal agents in experimental murine sporotrichosis. Antimicrob Agents Chemother. 1988 Nov;32(11):1619-23. PubMed PMID: 2855294; PubMed Central PMCID: PMC175939.