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MedKoo Cat#: 599296 | Name: Amipizone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amipizone is a phosphodiesterase inhibitor.

Chemical Structure

Amipizone
Amipizone
CAS#69635-63-8

Theoretical Analysis

MedKoo Cat#: 599296

Name: Amipizone

CAS#: 69635-63-8

Chemical Formula: C14H16ClN3O2

Exact Mass: 293.0931

Molecular Weight: 293.75

Elemental Analysis: C, 57.24; H, 5.49; Cl, 12.07; N, 14.30; O, 10.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Amipizone; Amipizonum; LU 23051; LU-23051; LU23051
IUPAC/Chemical Name
2-chloro-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)propanamide
InChi Key
NQWQBGBWCJSARZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H16ClN3O2/c1-8-7-12(19)17-18-13(8)10-3-5-11(6-4-10)16-14(20)9(2)15/h3-6,8-9H,7H2,1-2H3,(H,16,20)(H,17,19)
SMILES Code
CC(Cl)C(NC1=CC=C(C(C(C)C2)=NNC2=O)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Amicone L, Citarella F, Cicchini C. Epigenetic regulation in hepatocellular carcinoma requires long noncoding RNAs. Biomed Res Int. 2015;2015:473942. doi: 10.1155/2015/473942. Epub 2015 Mar 10. Review. PubMed PMID: 25861629; PubMed Central PMCID: PMC4377435. 2: Strippoli R, Moreno-Vicente R, Battistelli C, Cicchini C, Noce V, Amicone L, Marchetti A, Del Pozo MA, Tripodi M. Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis. Stem Cells Int. 2016;2016:3543678. doi: 10.1155/2016/3543678. Epub 2016 Jan 31. Review. PubMed PMID: 26941801; PubMed Central PMCID: PMC4752998. 3: De Santis Puzzonia M, Cozzolino AM, Grassi G, Bisceglia F, Strippoli R, Guarguaglini G, Citarella F, Sacchetti B, Tripodi M, Marchetti A, Amicone L. TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure. PLoS One. 2016 Nov 28;11(11):e0167158. doi: 10.1371/journal.pone.0167158. eCollection 2016. PubMed PMID: 27893804; PubMed Central PMCID: PMC5125678. 4: Cozzolino AM, Noce V, Battistelli C, Marchetti A, Grassi G, Cicchini C, Tripodi M, Amicone L. Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes. Stem Cells Int. 2016;2016:5481493. doi: 10.1155/2016/5481493. Epub 2016 Jan 12. PubMed PMID: 27057172; PubMed Central PMCID: PMC4737459. 5: Pisani A, Sabbatini M, Imbriaco M, Riccio E, Rubis N, Prinster A, Perna A, Liuzzi R, Spinelli L, Santangelo M, Remuzzi G, Ruggenenti P; ALADIN Study Group. Long-term Effects of Octreotide on Liver Volume in Patients With Polycystic Kidney and Liver Disease. Clin Gastroenterol Hepatol. 2016 Jul;14(7):1022-1030.e4. doi: 10.1016/j.cgh.2015.12.049. Epub 2016 Feb 1. PubMed PMID: 26844873. 6: Cicchini C, Amicone L, Alonzi T, Marchetti A, Mancone C, Tripodi M. Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte. Liver Int. 2015 Feb;35(2):302-10. doi: 10.1111/liv.12577. Epub 2014 May 20. Review. PubMed PMID: 24766136; PubMed Central PMCID: PMC4344819. 7: Cicchini C, de Nonno V, Battistelli C, Cozzolino AM, De Santis Puzzonia M, Ciafrè SA, Brocker C, Gonzalez FJ, Amicone L, Tripodi M. Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. Biochim Biophys Acta. 2015 Aug;1849(8):919-29. doi: 10.1016/j.bbagrm.2015.05.005. Epub 2015 May 21. PubMed PMID: 26003733. 8: Garibaldi F, Cicchini C, Conigliaro A, Santangelo L, Cozzolino AM, Grassi G, Marchetti A, Tripodi M, Amicone L. An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs. Cell Death Differ. 2012 Jun;19(6):937-46. doi: 10.1038/cdd.2011.175. Epub 2011 Dec 2. PubMed PMID: 22139130; PubMed Central PMCID: PMC3354047. 9: Montaldo C, Mattei S, Baiocchini A, Rotiroti N, Del Nonno F, Pucillo LP, Cozzolino AM, Battistelli C, Amicone L, Ippolito G, van Noort V, Conigliaro A, Alonzi T, Tripodi M, Mancone C. Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload. Proteomics. 2014 May;14(9):1107-15. doi: 10.1002/pmic.201300422. PubMed PMID: 24616218. 10: Milano C, Sessa G, Amicone A. [Tarso-metatarsal arthrodesis in therapy of anterior pes cavus. Long-term results]. Chir Organi Mov. 1980 Nov-Dec;66(6):715-20. Italian. PubMed PMID: 7347644. 11: Simonelli F, Giovane A, Frunzio S, Balestrieri P, Amicone A, Rinaldi M, Cotticelli L, Rinaldi E. Galactokinase activity in patients with idiopathic presenile and senile cataract. Metab Pediatr Syst Ophthalmol (1985). 1992;15(4):53-6. PubMed PMID: 1305705. 12: Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F, Brenner DA, Kisseleva T, Bianco P, Tripodi M. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Cell Death Differ. 2013 Aug;20(8):1116-23. doi: 10.1038/cdd.2013.49. Epub 2013 May 17. PubMed PMID: 23686136; PubMed Central PMCID: PMC3705603. 13: Amicone L, Spagnoli FM, Späth G, Giordano S, Tommasini C, Bernardini S, De Luca V, Della Rocca C, Weiss MC, Comoglio PM, Tripodi M. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J. 1997 Feb 3;16(3):495-503. PubMed PMID: 9034332; PubMed Central PMCID: PMC1169653. 14: Danubio ME, Amicone E. Biodemographic study of a central Apennine area (Italy) in the 19th and 20th centuries: marriage seasonality and reproductive isolation. J Biosoc Sci. 2001 Jul;33(3):427-49. PubMed PMID: 11446403. 15: Amicone L, Galimi MA, Spagnoli FM, Tommasini C, De Luca V, Tripodi M. Temporal and tissue-specific expression of the MET ORF driven by the complete transcriptional unit of human A1AT gene in transgenic mice. Gene. 1995 Sep 11;162(2):323-8. PubMed PMID: 7557452. 16: Conigliaro A, Colletti M, Cicchini C, Guerra MT, Manfredini R, Zini R, Bordoni V, Siepi F, Leopizzi M, Tripodi M, Amicone L. Isolation and characterization of a murine resident liver stem cell. Cell Death Differ. 2008 Jan;15(1):123-33. Epub 2007 Oct 12. PubMed PMID: 17932501. 17: Colletti M, Cicchini C, Conigliaro A, Santangelo L, Alonzi T, Pasquini E, Tripodi M, Amicone L. Convergence of Wnt signaling on the HNF4alpha-driven transcription in controlling liver zonation. Gastroenterology. 2009 Aug;137(2):660-72. doi: 10.1053/j.gastro.2009.05.038. Epub 2009 May 18. Erratum in: Gastroenterology. 2010 Feb;138(2):793. PubMed PMID: 19454287. 18: Fabbro De Suasnábar D, Arias E, Streiger M, Piacenza M, Ingaramo M, Del Barco M, Amicone N. Evolutive behavior towards cardiomyopathy of treated (nifurtimox or benznidazole) and untreated chronic chagasic patients. Rev Inst Med Trop Sao Paulo. 2000 Mar-Apr;42(2):99-109. PubMed PMID: 10810325. 19: Strakowski SM, Tsai SY, Delbello MP, Chen CC, Fleck DE, Adler CM, Arndt S, Amicone J. Outcome following a first manic episode: cross-national US and Taiwan comparison. Bipolar Disord. 2007 Dec;9(8):820-7. PubMed PMID: 18076531. 20: Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio AM, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M. Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium. PLoS One. 2012;7(12):e51109. doi: 10.1371/journal.pone.0051109. Epub 2012 Dec 4. PubMed PMID: 23226561; PubMed Central PMCID: PMC3514182.