Salvigenin | CAS#19103-54-9 | polyphenolic compound

MedKoo Cat#: 461734 | Name: Salvigenin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Salvigenin is a natural polyphenolic compound that has been shown to contribute to the augmentation of antitumor immunity. Salvigenin (SGN) is a flavonoid which demonstrates a wide range of biological and pharmacological abilities.

Chemical Structure

Salvigenin

CAS#19103-54-9

Theoretical Analysis

MedKoo Cat#: 461734

Name: Salvigenin

CAS#: 19103-54-9

Chemical Formula: C18H16O6

Exact Mass: 328.0947

Molecular Weight: 328.32

Elemental Analysis: C, 65.85; H, 4.91; O, 29.24

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 550.00	2 Weeks
10mg	USD 1,000.00	2 Weeks

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Related CAS #

No Data

Synonym

Salvigenin;

IUPAC/Chemical Name

5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

InChi Key

QCDYOIZVELGOLZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)13-8-12(19)16-14(24-13)9-15(22-2)18(23-3)17(16)20/h4-9,20H,1-3H3

SMILES Code

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(OC)=C(OC)C(O)=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 328.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Edwards H, Javed K, Yadev K, Ara C, Omer AM. Therapeutic potential of salvigenin to combat atrazine induced liver toxicity in rats via regulating Nrf-2/Keap-1 and NF-κB pathway. Pestic Biochem Physiol. 2024 Jun;202:105966. doi: 10.1016/j.pestbp.2024.105966. Epub 2024 May 24. PMID: 38879343. 2: Yasmeen N, Chaudhary AA, Khan S, Ayyar PV, Lakhawat SS, Sharma PK, Kumar V. Antiangiogenic potential of phytochemicals from Clerodendrum inerme (L.) Gaertn investigated through in silico and quantum computational methods. Mol Divers. 2024 Apr 28. doi: 10.1007/s11030-024-10846-4. Epub ahead of print. PMID: 38678137. 3: Zhao J, Wu K, Yang Y, Liu D, Zhang C, Li X. Novel Pt(IV) complexes containing salvigenin ligand reverse cisplatin-induced resistance by inhibiting Rap1b-mediated cancer cell stemness in esophageal squamous cell carcinoma treatments. Bioorg Chem. 2024 Jun;147:107384. doi: 10.1016/j.bioorg.2024.107384. Epub 2024 Apr 16. PMID: 38643568. 4: Darrag HM, Ghazzawy HS, Nasser Alzain M, Hakami EH, Almuhanna HT, Alqahtani NK. Exploring Ocimum basilicum's Secondary Metabolites: Inhibition and Molecular Docking against Rhynchophorus ferrugineus for Optimal Action. Plants (Basel). 2024 Feb 8;13(4):491. doi: 10.3390/plants13040491. PMID: 38498430; PMCID: PMC10892409. 5: Bayat Z, Mazaheri T, Farhadifard H, Taherkhani A. Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches. Biomed Res Int. 2024 Jan 30;2024:1236910. doi: 10.1155/2024/1236910. PMID: 38322303; PMCID: PMC10846925. 6: Yasmeen N, Ahmad Chaudhary A, K Niraj RR, Lakhawat SS, Sharma PK, Kumar V. Screening of phytochemicals from Clerodendrum inerme (L.) Gaertn as potential anti-breast cancer compounds targeting EGFR: an in-silico approach. J Biomol Struct Dyn. 2023 Dec 23:1-43. doi: 10.1080/07391102.2023.2294379. Epub ahead of print. Erratum in: J Biomol Struct Dyn. 2024 Feb-Mar;42(3):1615. doi: 10.1080/07391102.2024.2306063. PMID: 38141177. 7: Guo J, Mei ZW, Wang XJ, Li Q, Qin J. Molecular docking and network pharmacological analysis of Scutellaria baicalensis against renal cell carcinoma. Eur Rev Med Pharmacol Sci. 2023 Dec;27(23):11574-11586. doi: 10.26355/eurrev_202312_34596. PMID: 38095405. 8: Zayed A, Farag MA, Mehring A, Salem MA, Ibrahim RM, Alseekh S, Fernie AR, Ulber R. Methyl jasmonate elicitation effect on the metabolic profile of cambial meristematic cells culture derived from sweet basil (Ocimum basilicum L.) in relation to antioxidant activity: Untargeted metabolomics study in a time-based approach. Phytochemistry. 2023 Sep;213:113777. doi: 10.1016/j.phytochem.2023.113777. Epub 2023 Jun 28. PMID: 37385363. 9: Dalawai D, Murthy HN, Dewir YH, Sebastian JK, Nag A. Phytochemical Composition, Bioactive Compounds, and Antioxidant Properties of Different Parts of Andrographis macrobotrys Nees. Life (Basel). 2023 May 11;13(5):1166. doi: 10.3390/life13051166. PMID: 37240810; PMCID: PMC10223075. 10: Rosdianto RS, Zakiyah N, Viviani RN, Saesarria Deisberanda F, Nareswari TL, Satrialdi, Fidrianny I, Adhika DR, Waresindo WX, Supratman U, Suciati T. Novel Insight into Pickering Emulsion and Colloidal Particle Network Construction of Basil Extract for Enhancing Antioxidant and UV-B-Induced Antiaging Activities. ACS Omega. 2023 Apr 26;8(18):15932-15950. doi: 10.1021/acsomega.2c07657. PMID: 37179601; PMCID: PMC10173343. 11: Shao H, Chen J, Li A, Ma L, Tang Y, Chen H, Chen Y, Liu J. Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway. Appl Biochem Biotechnol. 2023 Aug;195(8):5217-5237. doi: 10.1007/s12010-023-04511-z. Epub 2023 May 2. PMID: 37129745; PMCID: PMC10354167. 12: Doğan M, Koçyiğit ÜM, Çetin FN, Yılmaz BN, Taşkın T. Composition characterization and biological activity study of Achillea vermicularis extract and extract-loaded nanoparticles. Biotechnol Appl Biochem. 2023 Jun;70(3):1270-1278. doi: 10.1002/bab.2437. Epub 2023 Jan 9. PMID: 36594704. 13: Pinto AA, Ruano-González A, Ezzanad A, Pinedo-Rivilla C, Sánchez-Maestre R, Amaro-Luis JM. Bio-Guided Isolation of New Compounds from Baccharis spp. as Antifungal against Botrytis cinerea. Metabolites. 2022 Dec 19;12(12):1292. doi: 10.3390/metabo12121292. PMID: 36557330; PMCID: PMC9781812. 14: Vidhya Rekha U, Varadhachariyar R, Rajagopal P, Priya PH, Shazia Fathima JH, Govindan R, Palanisamy CP, Veeraraghavan VP, Jayaraman S. Molecular docking analysis of bioactive compounds from Plectranthus amboinicus with glucokinase. Bioinformation. 2022 Mar 31;18(3):261-264. doi: 10.6026/97320630018261. PMID: 36518120; PMCID: PMC9722418. 15: Gong S, Cheng B, Sun T, Li X, Liang X, Wang Y, Dai X, Xiao W. Cathayanalactone G and other constituents from leaves and twigs of Callicarpa cathayana. Chin Herb Med. 2022 Feb 26;14(2):332-336. doi: 10.1016/j.chmed.2021.05.006. PMID: 36117667; PMCID: PMC9476795. 16: Bonokwane MB, Lekhooa M, Struwig M, Aremu AO. Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies. Front Pharmacol. 2022 Jun 29;13:895286. doi: 10.3389/fphar.2022.895286. PMID: 35846999; PMCID: PMC9277359. 17: Darrag HM, Almuhanna HT, Hakami EH. Secondary Metabolites in Basil, Bio- Insecticide, Inhibition Effect, and In Silico Molecular Docking against Proteolytic Enzymes of the Red Palm Weevil (Rhynchophorus ferrugineus). Plants (Basel). 2022 Apr 16;11(8):1087. doi: 10.3390/plants11081087. PMID: 35448815; PMCID: PMC9027599. 18: Ugbogu OC, Emmanuel O, Agi GO, Ibe C, Ekweogu CN, Ude VC, Uche ME, Nnanna RO, Ugbogu EA. A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.). Heliyon. 2021 Nov 25;7(11):e08404. doi: 10.1016/j.heliyon.2021.e08404. PMID: 34901489; PMCID: PMC8642617. 19: Aihaiti K, Li J, Yaermaimaiti S, Liu L, Xin X, Aisa HA. Non-volatile compounds of Hyssopus cuspidatus Boriss and their antioxidant and antimicrobial activities. Food Chem. 2022 Apr 16;374:131638. doi: 10.1016/j.foodchem.2021.131638. Epub 2021 Nov 19. PMID: 34839965. 20: Akdeniz M, Yener I, Dincel D, Firat M, Karatas Degirmenci D, Ertas A. Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC-MS: Source species for valuable compounds with drug or drug potential. Biomed Chromatogr. 2022 Feb;36(2):e5263. doi: 10.1002/bmc.5263. Epub 2021 Nov 18. PMID: 34647633.