Synonym
Sulfathiourea; Fontamide; Badional; Salvoseptyl; Sulfathiocarbamidum;
IUPAC/Chemical Name
4-amino-N-carbamothioylbenzenesulfonamide
InChi Key
UEMLYRZWLVXWRU-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H9N3O2S2/c8-5-1-3-6(4-2-5)14(11,12)10-7(9)13/h1-4H,8H2,(H3,9,10,13)
SMILES Code
S=C(N)NS(=O)(C1=CC=C(N)C=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
231.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: El-Fatatry HM, Sharaf El-Deen MM, Amer MM. Application of Henderson equation for the determination of weakly acidic pharmaceutical compounds. Part 1: Determination of sulfathiourea. Pharmazie. 1978 May;33(5):282-4. PubMed PMID: 674338.
2: Czeizel AE, Puhó E, Sørensen HT, Olsen J. Possible association between different congenital abnormalities and use of different sulfonamides during pregnancy. Congenit Anom (Kyoto). 2004 Jun;44(2):79-86. PubMed PMID: 15198720.
3: THIERS H, COLOMB D, FAYOLLE J. [Sulfathiourea in therapy of nodular or patchy eruptive hypodermatites]. Bull Soc Fr Dermatol Syphiligr. 1957 Apr-May;64(2):140-1. French. PubMed PMID: 13460623.
4: SCHOOG M. [Sulfathiourea, chemistry, pharmacology and clinical aspects]. Z Haut Geschlechtskr. 1953 Nov 15;15(10):315-8. Undetermined Language. PubMed PMID: 13137202.
5: SAMPAIO S, MARTIRANI A. [Treatment of veneral chancre with sulfathiourea]. Rev Paul Med. 1949 Sep;35(3):207-10. Portuguese. PubMed PMID: 18139882.
6: ZOLLNER E, VASTAGH G. [Colorimetric determination of sulfathiourea (badional)]. Pharm Zentralhalle Dtschl. 1958 May;97(5):219-23. German. PubMed PMID: 13566968.
7: WEINSTEIN L, CHANG TW, MURPHY EB, HUDSON JB. Studies of sulfathiourea; in vivo and in vitro activity, reactivity to p-aminobenzoic acid, mode of action, with some comparisons with sulfadimetine. Antibiot Chemother (Northfield). 1956 Jul;6(7):429-43. PubMed PMID: 24544024.
8: Palló N, Török I, Paál T. [Chromatographic separation and simultaneous determination of sulfathiourea, sulfamethoxypyridazine and sulfadimidine]. Acta Pharm Hung. 1988 May;58(3):105-13. Hungarian. PubMed PMID: 3245446.
9: THIERS H, COLOMB. [The syndrome of focal angina, rheumatismal state and so-called allergic hypodermitis; treatment by sulfathiourea]. Rev Rhum Mal Osteoartic. 1953 Aug-Sep;20(8-9):645-7. Undetermined Language. PubMed PMID: 13121788.
10: ROCHE G, PELLERIN F, JUTEAU C, JUTEAU J. [Comparative pleural permeability of healthy and pathological pleura; injections of sulfathiourea]. Rev Tuberc. 1957 Jul-Aug;21(7-8):833-56. French. PubMed PMID: 13495112.
11: BERGMANN F. Suflathiourea. J Am Chem Soc. 1946 May;68:761-4. PubMed PMID: 21024878.
12: Hong YL, Hossler PA, Calhoun DH, Meshnick SR. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. PubMed PMID: 7486915; PubMed Central PMCID: PMC162822.
13: CELICE J, BOUDREAUX J. [Not Available]. Gaz Med Fr. 1946;53(6):133-7. Undetermined Language. PubMed PMID: 21025532.
14: Askal HF, Saleh GA. Spectrophotometric methods for the determination of sulphathiourea. J Pharm Biomed Anal. 1991;9(4):297-301. PubMed PMID: 1911981.
15: Abdellatef HE, Elbalkiny MN, Aboulkheir A. Determination of sulphacetamide, sulphadimidine or sulphathiourea in the presence of their degradation products using first derivative spectrophotometry. J Pharm Biomed Anal. 1989;7(5):571-6. PubMed PMID: 2490761.
