LR 16 | CAS#117011-50-4 | oxygen affinity

MedKoo Cat#: 599274 | Name: LR 16

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LR 16 has potent effects on oxygen affinity of hemoglobin, on blood cholesterol and on low density lipoprotein.

Chemical Structure

LR 16

CAS#117011-50-4

Theoretical Analysis

MedKoo Cat#: 599274

Name: LR 16

CAS#: 117011-50-4

Chemical Formula: C17H16Cl2N2O4

Exact Mass: 382.0487

Molecular Weight: 383.22

Elemental Analysis: C, 53.28; H, 4.21; Cl, 18.50; N, 7.31; O, 16.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

LR 16; LR-16; LR16;

IUPAC/Chemical Name

2-(4-(3-(3,4-dichlorophenyl)ureido)phenoxy)-2-methylpropanoic acid

InChi Key

KBLJQBLVEDGLEM-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H16Cl2N2O4/c1-17(2,15(22)23)25-12-6-3-10(4-7-12)20-16(24)21-11-5-8-13(18)14(19)9-11/h3-9H,1-2H3,(H,22,23)(H2,20,21,24)

SMILES Code

CC(C)(OC1=CC=C(NC(NC2=CC=C(Cl)C(Cl)=C2)=O)C=C1)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 383.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lalezari I, Lalezari P, Poyart C, Marden M, Kister J, Bohn B, Fermi G, Perutz MF. New effectors of human hemoglobin: structure and function. Biochemistry. 1990 Feb 13;29(6):1515-23. PubMed PMID: 2334712. 2: Hawke RL, Chapman JM, Winegar DA, Salisbury JA, Welch RM, Brown A, Franzmann KW, Sigel C. Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity. J Lipid Res. 1997 Jun;38(6):1189-203. PubMed PMID: 9215547. 3: Lalezari I, Rahbar S, Lalezari P, Fermi G, Perutz MF. LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholesterol, and on low density lipoprotein. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6117-21. PubMed PMID: 3413080; PubMed Central PMCID: PMC281916.