Loureirin B is a flavonoid originally isolated from D. cochinchinensis, a major component of the traditional herbal medicine "Dragon's Blood." It inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells. It also inhibits phytohemagglutinin-induced IL-2 release from these cells. Loureirin B reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay.2 It reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue. Loureirin B increases glucose absorption and intracellular ATP levels in Ins-1 cells via inhibition of the KATP current and intracellular influx of calcium.
MedKoo Cat#: 599262
Name: Loureirin B
CAS#: 119425-90-0
Chemical Formula: C18H20O5
Exact Mass: 316.1311
Molecular Weight: 316.35
Elemental Analysis: C, 68.34; H, 6.37; O, 25.29
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 94.83 | |
| DMSO | 93.3 | 295.03 | |
| DMSO:PBS (pH 7.2) (1:2) | 0.3 | 1.04 |
The following data is based on the product molecular weight 316.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
