Tolcaine HCl | CAS#33697-73-3 | bioactive chemical

MedKoo Cat#: 599256 | Name: Tolcaine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolcaine HCl is a bioactive chemical.

Chemical Structure

Tolcaine HCl

CAS#33697-73-3

Theoretical Analysis

MedKoo Cat#: 599256

Name: Tolcaine HCl

CAS#: 33697-73-3

Chemical Formula: C18H30ClNO2

Exact Mass:

Molecular Weight: 327.89

Elemental Analysis: C, 65.94; H, 9.22; Cl, 10.81; N, 4.27; O, 9.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Tolcaine hydrochloride; Tolcaine HCl; MY 33-7; MY-33-7; MY33-7;

IUPAC/Chemical Name

1-(2,2,5,5-tetramethylpyrrolidin-1-yl)-3-(o-tolyloxy)propan-2-ol hydrochloride

InChi Key

AGPGNIVJVGCHFO-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H29NO2.ClH/c1-14-8-6-7-9-16(14)21-13-15(20)12-19-17(2,3)10-11-18(19,4)5;/h6-9,15,20H,10-13H2,1-5H3;1H

SMILES Code

OC(COC1=CC=CC=C1C)CN2C(C)(C)CCC2(C)C.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 327.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Colley VL, Casale JF. Differentiation of South American crack and domestic (US) crack cocaine via headspace-gas chromatography/mass spectrometry. Drug Test Anal. 2015 Mar;7(3):241-6. doi: 10.1002/dta.1729. Epub 2014 Oct 9. PubMed PMID: 25303034. 2: van Heugten-Van der Kloet D, Giesbrecht T, van Wel J, Bosker WM, Kuypers KP, Theunissen EL, Spronk DB, Jan Verkes R, Merckelbach H, Ramaekers JG. MDMA, cannabis, and cocaine produce acute dissociative symptoms. Psychiatry Res. 2015 Aug 30;228(3):907-12. doi: 10.1016/j.psychres.2015.04.028. Epub 2015 Apr 30. PubMed PMID: 26003508. 3: Mitchell MR, Weiss VG, Ouimet DJ, Fuchs RA, Morgan D, Setlow B. Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. Behav Neurosci. 2014 Aug;128(4):419-29. doi: 10.1037/a0036742. Epub 2014 May 19. PubMed PMID: 24841739; PubMed Central PMCID: PMC4107092. 4: Mejías-Aponte CA, Kiyatkin EA. Ventral tegmental area neurons are either excited or inhibited by cocaine's actions in the peripheral nervous system. Neuroscience. 2012 Apr 5;207:182-97. doi: 10.1016/j.neuroscience.2012.01.026. Epub 2012 Jan 20. PubMed PMID: 22300980; PubMed Central PMCID: PMC3325788. 5: Stewart MJ, Fulton HG, Barrett SP. Powder and crack cocaine use among opioid users: is all cocaine the same? J Addict Med. 2014 Jul-Aug;8(4):264-70. doi: 10.1097/ADM.0000000000000047. PubMed PMID: 24950136. 6: Bruner NR, Johnson MW. Demand curves for hypothetical cocaine in cocaine-dependent individuals. Psychopharmacology (Berl). 2014 Mar;231(5):889-97. doi: 10.1007/s00213-013-3312-5. Epub 2013 Nov 12. PubMed PMID: 24217899; PubMed Central PMCID: PMC3945407. 7: Zhu H, Wilson FA, Stimpson JP, Pagán JA. Correlation between cocaine prices and purity with trends in emergency department visits in a major metropolitan area. J Urban Health. 2014 Oct;91(5):1009-18. doi: 10.1007/s11524-014-9899-y. PubMed PMID: 25159195; PubMed Central PMCID: PMC4199440. 8: Wetzel HN, Tabet MR, Ball WJ, Norman AB. The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice. Int Immunopharmacol. 2014 Dec;23(2):387-90. Erratum in: Int Immunopharmacol. 2016 Feb;31:272-3. PubMed PMID: 25445957; PubMed Central PMCID: PMC4293271. 9: van Wel JH, Kuypers KP, Theunissen EL, Toennes SW, Spronk DB, Verkes RJ, Ramaekers JG. Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users. Br J Pharmacol. 2013 Dec;170(7):1410-20. doi: 10.1111/bph.12425. PubMed PMID: 24106872; PubMed Central PMCID: PMC3838687. 10: Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology. 2013 Oct;38(11):2170-8. doi: 10.1038/npp.2013.114. Epub 2013 May 10. PubMed PMID: 23660705; PubMed Central PMCID: PMC3773666. 11: Clifford PS, Rodriguez J, Schul D, Hughes S, Kniffin T, Hart N, Eitan S, Brunel L, Fehrentz JA, Martinez J, Wellman PJ. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol. 2012 Nov;17(6):956-63. doi: 10.1111/j.1369-1600.2011.00339.x. Epub 2011 Jul 25. PubMed PMID: 21790898; PubMed Central PMCID: PMC3204336. 12: Al-Hasani R, McCall JG, Foshage AM, Bruchas MR. Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism. Neuropsychopharmacology. 2013 Nov;38(12):2484-97. doi: 10.1038/npp.2013.151. Epub 2013 Jun 21. PubMed PMID: 23787819; PubMed Central PMCID: PMC3799068. 13: van Wel JH, Spronk DB, Kuypers KP, Theunissen EL, Toennes SW, Verkes RJ, Ramaekers JG. Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity. J Psychopharmacol. 2015 Mar;29(3):324-34. doi: 10.1177/0269881114563633. Epub 2015 Jan 8. PubMed PMID: 25572345. 14: Mielczarek P, Raoof H, Kotlinska JH, Stefanowicz P, Szewczuk Z, Suder P, Silberring J. Electrochemical simulation of cocaine metabolism-a step toward predictive toxicology for drugs of abuse. Eur J Mass Spectrom (Chichester). 2014;20(4):279-85. PubMed PMID: 25420340. 15: Ellefsen KN, da Costa JL, Concheiro M, Anizan S, Barnes AJ, Pirard S, Gorelick DA, Huestis MA. Cocaine and metabolite concentrations in DBS and venous blood after controlled intravenous cocaine administration. Bioanalysis. 2015;7(16):2041-56. doi: 10.4155/bio.15.127. PubMed PMID: 26327184; PubMed Central PMCID: PMC4644129. 16: Rice OV, Heidbreder CA, Gardner EL, Schonhar CD, Ashby CR Jr. The selective D₃ receptor antagonist SB-277011A attenuates morphine-triggered reactivation of expression of cocaine-induced conditioned place preference. Synapse. 2013 Aug;67(8):469-75. doi: 10.1002/syn.21653. Epub 2013 Mar 25. PubMed PMID: 23404528; PubMed Central PMCID: PMC4929856. 17: Thibert V, Legeay P, Chapuis-Hugon F, Pichon V. Molecularly imprinted polymer for the selective extraction of cocaine and its metabolites, benzoylecgonine and ecgonine methyl ester, from biological fluids before LC-MS analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 15;949-950:16-23. doi: 10.1016/j.jchromb.2013.11.051. Epub 2013 Dec 15. PubMed PMID: 24444871. 18: Barreto-Valer K, López-Bellido R, Macho Sánchez-Simón F, Rodríguez RE. Modulation by cocaine of dopamine receptors through miRNA-133b in zebrafish embryos. PLoS One. 2012;7(12):e52701. doi: 10.1371/journal.pone.0052701. Epub 2012 Dec 21. PubMed PMID: 23285158; PubMed Central PMCID: PMC3528707. 19: Porter-Stransky KA, Wescott SA, Hershman M, Badrinarayan A, Vander Weele CM, Lovic V, Aragona BJ. Cocaine must enter the brain to evoke unconditioned dopamine release within the nucleus accumbens shell. Neurosci Lett. 2011 Oct 17;504(1):13-7. doi: 10.1016/j.neulet.2011.08.028. Epub 2011 Aug 24. PubMed PMID: 21888949. 20: Collins GT, Jackson JA, Koek W, France CP. Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition. Eur J Pharmacol. 2014 Apr 15;729:123-31. doi: 10.1016/j.ejphar.2014.02.014. Epub 2014 Feb 20. PubMed PMID: 24561049; PubMed Central PMCID: PMC4009742.