NSC66811 | CAS#6964-62-1 | MDM2-p53 inhibitor

MedKoo Cat#: 563677 | Name: NSC66811

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC66811 is a potent inhibitor of the human murine double minute 2 (MDM2)-p53 interaction.

Chemical Structure

NSC66811

CAS#6964-62-1

Theoretical Analysis

MedKoo Cat#: 563677

Name: NSC66811

CAS#: 6964-62-1

Chemical Formula: C23H20N2O

Exact Mass: 340.1576

Molecular Weight: 340.43

Elemental Analysis: C, 81.15; H, 5.92; N, 8.23; O, 4.70

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 220.00
5mg	USD 380.00
10mg	USD 610.00

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Related CAS #

No Data

Synonym

NSC66811; NSC-66811; NSC 66811;

IUPAC/Chemical Name

2-Methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol

InChi Key

WEENRMPCSWFMTE-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3

SMILES Code

OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2.

In vitro activity:

An integrated, virtual database screening strategy has led to 7-[anilino(phenyl)methyl]-2-methyl-8-quinolinol (4, NSC 66811) as a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. Reference: J Med Chem. 2006 Jun 29;49(13):3759-62. https://pubmed.ncbi.nlm.nih.gov/16789731/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	33.0	96.94
	DMF:PBS (pH 7.2) (1:2)	0.3	0.88
	DMSO	62.5	183.59
	Ethanol	1.0	2.94

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 340.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Lu Y, Nikolovska-Coleska Z, Fang X, Gao W, Shangary S, Qiu S, Qin D, Wang S. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62. doi: 10.1021/jm060023+. PMID: 16789731.

In vitro protocol:

In vivo protocol:

TBD

1: Lu Y, Nikolovska-Coleska Z, Fang X, Gao W, Shangary S, Qiu S, Qin D, Wang S. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49(13):3759-62. PubMed PMID: 16789731.