MedKoo Cat#: 461685 | Name: Cevine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cevine is a crystalline alkaloid found in sabadilla seeds and formed from cevadine by hydrolysis.

Chemical Structure

Cevine
Cevine
CAS#124-98-1

Theoretical Analysis

MedKoo Cat#: 461685

Name: Cevine

CAS#: 124-98-1

Chemical Formula: C27H43NO8

Exact Mass: 509.2989

Molecular Weight: 509.64

Elemental Analysis: C, 63.63; H, 8.50; N, 2.75; O, 25.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cevine; Cevin; Sabadinine;
IUPAC/Chemical Name
(3R,4S,4aS,6aS,6bR,8S,8aS,9R,9aS,12S,15aS,15bR,16bS)-9,12,16b-trimethylhexadecahydro-2H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinoline-3,4,6b,8,8a,9,15b(3H,16H)-heptaol
InChi Key
MZHXYVMEVBEFAL-UELXFEKFSA-N
InChi Code
InChI=1S/C27H43NO8/c1-14-4-7-18-22(3,31)26(34)17(12-28(18)11-14)24(33)13-25-16(23(24,32)10-20(26)30)6-5-15-21(25,2)9-8-19(29)27(15,35)36-25/h14-20,29-35H,4-13H2,1-3H3/t14-,15-,16-,17-,18-,19+,20-,21-,22+,23+,24+,25?,26-,27-/m0/s1
SMILES Code
[H][C@@]12[C@@](O3)(O)[C@H](O)CC[C@]1(C)C43C[C@@]5(O)[C@]6([H])CN7C[C@@H](C)CC[C@]([H])7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]5(O)[C@]4([H])CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 509.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: AUTERHOFF H, STECHER KW. [ON DATA ON A BASIC DEGRADATION PRODUCT OF CEVINE. 13. SABADILLA AND VERATRUM ALKALOIDS]. Arch Pharm Ber Dtsch Pharm Ges. 1963 Oct;296:660-4. German. PubMed PMID: 14205484. 2: Badria FA, McChesney JD, Halim AF, Zaghloul AM, el Sayed KA. Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids. Pharmazie. 1995 Jun;50(6):421-3. PubMed PMID: 7651981. 3: JAFFE H, JACOBS WA. The veratrine alkaloids. XXXIII. The isomeric forms of cevine, germine, and protoverine. J Biol Chem. 1951 Nov;193(1):325-37. PubMed PMID: 14907720. 4: BARTON DH, JEGER O, PRELOG V, WOODWARD RB. The constitutions of cevine and some related alkaloids. Experientia. 1954 Mar 15;10(3):81-90. PubMed PMID: 13161888. 5: FUKEL'MAN LM. [Chromatographic-qualitative and colorimetric-quantitative methods of determination of cevine in the green substance of plants and fruits]. Vopr Pitan. 1963 Mar-Apr;22:80-5. Russian. PubMed PMID: 13960158. 6: MOEHRLE H. [PREPARATION OF HYDROXYLACTAMS BY MERCURY(II)-EDTA DEHYDRATION. 1. MODEL ATTEMPTS FOR THE DEHYDRATION OF CEVINE]. Arch Pharm Ber Dtsch Pharm Ges. 1964 Aug;297:474-87. German. PubMed PMID: 14344690. 7: Brown GB, Tieszen SC, Daly JW, Warnick JE, Albuquerque EX. Batrachotoxinin-A 20-alpha-benzoate: a new radioactive ligand for voltage sensitive sodium channels. Cell Mol Neurobiol. 1981 Mar;1(1):19-40. PubMed PMID: 6286124. 8: Toney JH, Navas-Martín S, Weiss SR, Koeller A. Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design. J Med Chem. 2004 Feb 26;47(5):1079-80. PubMed PMID: 14971887. 9: BOJANOVIC JJ, PAVLOVIC DB, SEVALJEVIC LM. [EFFECT OF SMALL AMOUNTS OF HEPARIN ON BLOOD PROTEINS IN VITRO. ELECTROPHORETIC PATTERNS OF PROTEIN FRACTIONS OF HEPARINIZED GUINEA PIG BLOOD PLASMA]. Acta Med Iugosl. 1964;18:1-9. Undetermined Language. PubMed PMID: 14230630. 10: BOJANOVIC JJ, SEVALJEVIC M. [PROTEINS, LIPIDS AND GLYCIDES IN THE COURSE OF AGING. IV. POLAROGRAPHIC ANALYSIS OF SOME BLOOD PROTEIN FRACTIONS IN GUINEA PIGS OF VARIOUS AGES]. Acta Med Iugosl. 1964;18:204-18. Undetermined Language. PubMed PMID: 14334542.