MedKoo Cat#: 599229 | Name: Isoloratadine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoloratadine is a Loratadine impurity. An isomer of Loratadine used for preparation of tricyclic amides and ureas useful for inhibition of G-protein function and for treatment of proliferative diseases.

Chemical Structure

Isoloratadine
Isoloratadine
CAS#170727-59-0

Theoretical Analysis

MedKoo Cat#: 599229

Name: Isoloratadine

CAS#: 170727-59-0

Chemical Formula: C22H23ClN2O2

Exact Mass: 382.1448

Molecular Weight: 382.89

Elemental Analysis: C, 69.01; H, 6.06; Cl, 9.26; N, 7.32; O, 8.36

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Synonym
Isoloratadine; Iso loratadine; Loratadine specified impurity E;
IUPAC/Chemical Name
ethyl 4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-3,6-dihydropyridine-1(2H)-carboxylate
InChi Key
ZORGYPXITGWTSB-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-9,11,14,20H,2,5-6,10,12-13H2,1H3
SMILES Code
O=C(N1CC=C(C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C42)CC1)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
Isoloratadine is a Loratadine impurity.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 382.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD