S 8308 | CAS#119256-78-9 | AII antagonist

MedKoo Cat#: 461660 | Name: S 8308

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S 8308 is a weak, but specific and competitive, non-peptide antagonist of AII exerting its inhibitory action at the receptor level.

Chemical Structure

S 8308

CAS#119256-78-9

Theoretical Analysis

MedKoo Cat#: 461660

Name: S 8308

CAS#: 119256-78-9

Chemical Formula: C16H17ClN3NaO4

Exact Mass: 373.0805

Molecular Weight: 373.76

Elemental Analysis: C, 51.42; H, 4.58; Cl, 9.48; N, 11.24; Na, 6.15; O, 17.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

S 8308; S-8308; S8308;

IUPAC/Chemical Name

sodium 2-(2-butyl-4-chloro-1-(2-nitrobenzyl)-1H-imidazol-5-yl)acetate

InChi Key

IOLLRZYQFFZPKF-UHFFFAOYSA-M

InChi Code

InChI=1S/C16H18ClN3O4.Na/c1-2-3-8-14-18-16(17)13(9-15(21)22)19(14)10-11-6-4-5-7-12(11)20(23)24;/h4-7H,2-3,8-10H2,1H3,(H,21,22);/q;+1/p-1

SMILES Code

O=C([O-])CC1=C(Cl)N=C(CCCC)N1CC2=CC=CC=C2[N+]([O-])=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 373.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chiu AT, Duncia JV, McCall DE, Wong PC, Price WA Jr, Thoolen MJ, Carini DJ, Johnson AL, Timmermans PB. Nonpeptide angiotensin II receptor antagonists. III. Structure-function studies. J Pharmacol Exp Ther. 1989 Sep;250(3):867-74. PubMed PMID: 2778716. 2: Chiu AT, Carini DJ, Johnson AL, McCall DE, Price WA, Thoolen MJ, Wong PC, Taber RI, Timmermans PB. Non-peptide angiotensin II receptor antagonists. II. Pharmacology of S-8308. Eur J Pharmacol. 1988 Nov 15;157(1):13-21. PubMed PMID: 3234494.