Pumafentrine | CAS#207993-12-2 | PDE3/4 inhibitor

MedKoo Cat#: 563658 | Name: Pumafentrine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pumafentrine is a dual inhibitor of PDE3 and PDE4.

Chemical Structure

Pumafentrine

CAS#207993-12-2

Theoretical Analysis

MedKoo Cat#: 563658

Name: Pumafentrine

CAS#: 207993-12-2

Chemical Formula: C29H39N3O3

Exact Mass: 477.2991

Molecular Weight: 477.64

Elemental Analysis: C, 72.92; H, 8.23; N, 8.80; O, 10.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Pumafentrine; BY343; BYK 33043; BY-343; BYK33043;

IUPAC/Chemical Name

4-((4aR,10bS)-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)-N,N-diisopropylbenzamide

InChi Key

CVDXFPBVOIERBH-JWQCQUIFSA-N

InChi Code

InChI=1S/C29H39N3O3/c1-8-35-27-15-22-23(16-26(27)34-7)28(30-25-13-14-31(6)17-24(22)25)20-9-11-21(12-10-20)29(33)32(18(2)3)19(4)5/h9-12,15-16,18-19,24-25H,8,13-14,17H2,1-7H3/t24-,25-/m1/s1

SMILES Code

O=C(N(C(C)C)C(C)C)C1=CC=C(C2=N[C@]3([H])CCN(C)C[C@]3([H])C4=CC(OCC)=C(OC)C=C24)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 477.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Page CP. Phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Int Arch Allergy Immunol. 2014;165(3):152-64. doi: 10.1159/000368800. Epub 2014 Dec 20. Review. PubMed PMID: 25532037. 2: Rieder F, Siegmund B, Bundschuh DS, Lehr HA, Endres S, Eigler A. The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. PLoS One. 2013;8(2):e56867. doi: 10.1371/journal.pone.0056867. Epub 2013 Feb 28. PubMed PMID: 23468885; PubMed Central PMCID: PMC3585290. 3: Dony E, Lai YJ, Dumitrascu R, Pullamsetti SS, Savai R, Ghofrani HA, Weissmann N, Schudt C, Flockerzi D, Seeger W, Grimminger F, Schermuly RT. Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition. Eur Respir J. 2008 Mar;31(3):599-610. Epub 2007 Nov 21. PubMed PMID: 18032446.