SSM3 TFA | CAS#922732-52-3 | furin inhibitor

MedKoo Cat#: 563651 | Name: SSM3 TFA

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SSM3 TFA is a potent furin inhibitor, blocking furin-dependent cell surface processing of anthrax protective antigen-83 in vitro..

Chemical Structure

SSM3 TFA

CAS#922732-52-3

Theoretical Analysis

MedKoo Cat#: 563651

Name: SSM3 TFA

CAS#: 922732-52-3

Chemical Formula: C30H36F12N12O10

Exact Mass: 0.0000

Molecular Weight: 952.67

Elemental Analysis: C, 37.82; H, 3.81; F, 23.93; N, 17.64; O, 16.79

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 550.00	2 Weeks

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Synonym

SSM3 TFA; SSM-3 TFA; SSM 3 TFA; SSM3 TFA salt;

IUPAC/Chemical Name

1,1'-((1R,3S,4S,6R)-4,6-bis(4-guanidinophenoxy)cyclohexane-1,3-diyl)diguanidine tetrakis(2,2,2-trifluoroacetate)

InChi Key

JYRRXGHBFAELIV-YAOLEPIASA-N

InChi Code

InChI=1S/C22H32N12O2.4C2HF3O2/c23-19(24)31-11-1-5-13(6-2-11)35-17-10-18(16(34-22(29)30)9-15(17)33-21(27)28)36-14-7-3-12(4-8-14)32-20(25)26;4*3-2(4,5)1(6)7/h1-8,15-18H,9-10H2,(H4,23,24,31)(H4,25,26,32)(H4,27,28,33)(H4,29,30,34);4*(H,6,7)/t15-,16+,17-,18+;;;;

SMILES Code

NC(N[C@H]1C[C@H]([C@@H](C[C@@H]1OC2=CC=C(C=C2)NC(N)=N)OC3=CC=C(C=C3)NC(N)=N)NC(N)=N)=N.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO and water

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SSM3 TFA is a potent furin inhibitor (EC50 = 54 nM).

In vitro activity:

To be determined

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMSO	49.7	100.00
	Water	49.7	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 952.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

To be determined

In vitro protocol:

To be determined

In vivo protocol:

To be determined

1: Remacle AG, Gawlik K, Golubkov VS, Cadwell GW, Liddington RC, Cieplak P, Millis SZ, Desjardins R, Routhier S, Yuan XW, Neugebauer WA, Day R, Strongin AY. Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. Int J Biochem Cell Biol. 2010 Jun;42(6):987-95. doi: 10.1016/j.biocel.2010.02.013. Epub 2010 Mar 1. PubMed PMID: 20197107; PubMed Central PMCID: PMC2862824.