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MedKoo Cat#: 563648 | Name: Tenidap Sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tenidap Sodium is a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent.

Chemical Structure

Tenidap Sodium
Tenidap Sodium
CAS#119784-94-0

Theoretical Analysis

MedKoo Cat#: 563648

Name: Tenidap Sodium

CAS#: 119784-94-0

Chemical Formula: C14H8ClN2NaO3S

Exact Mass: 341.9842

Molecular Weight: 342.72

Elemental Analysis: C, 49.06; H, 2.35; Cl, 10.34; N, 8.17; Na, 6.71; O, 14.00; S, 9.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Tenidap Sodium; CP-66248-2; CP 66248 2; CP662482;
IUPAC/Chemical Name
sodium (Z)-(1-carbamoyl-5-chloro-2-oxoindolin-3-ylidene)(thiophen-2-yl)methanolate
InChi Key
VCSAHSDZAKGXAT-AFEZEDKISA-M
InChi Code
InChI=1S/C14H9ClN2O3S.Na/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10;/h1-6,18H,(H2,16,20);/q;+1/p-1/b12-11-;
SMILES Code
O=C1N(C(N)=O)C2=C(C=C(Cl)C=C2)/C1=C(C3=CC=CS3)/O[Na]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy. Chin Med J (Engl). 2013;126(10):1900-5. PubMed PMID: 23673107. 5: Xu L, Hao Y, Wu X, Yu P, Zhu G, Hong Z. Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy. Neurol Res. 2013 Jul;35(6):561-7. doi: 10.1179/1743132813Y.0000000157. Epub 2013 Feb 7. PubMed PMID: 23561319. 6: Bulur N, Crutzen R, Malaisse WJ, Sener A, Beauwens R, Golstein P. Interaction between cAMP, volume regulated anion channels and the Na+ HCO3 cotransporter, NBCe1, in the regulation of nutrient and hypotonicity induced insulin release from isolated rat pancreatic islets and tumoral insulin producing BRIN BD11 cells. Mol Med Rep. 2013 May;7(5):1666-72. doi: 10.3892/mmr.2013.1346. Epub 2013 Feb 28. PubMed PMID: 23450392. 7: Mucsi Z, Porcs-Makkay M, Simig G, Csizmadia IG, Volk B. Application of the systems chemistry approach on the ammonolysis of 1-ethoxycarbonyl- and 1-phenoxycarbonyl-3-(2-thienyl)oxindoles. A method to predict reactivity. J Org Chem. 2012 Sep 7;77(17):7282-90. doi: 10.1021/jo300715d. Epub 2012 Aug 27. PubMed PMID: 22901033. 8: Parker MD, Qin X, Williamson RC, Toye AM, Boron WF. HCO(3)(-)-independent conductance with a mutant Na(+)/HCO(3)(-) cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalaemic paralysis. J Physiol. 2012 Apr 15;590(8):2009-34. doi: 10.1113/jphysiol.2011.224733. Epub 2012 Feb 13. PubMed PMID: 22331414; PubMed Central PMCID: PMC3573318. 9: Chávez JC, Hernández-González EO, Wertheimer E, Visconti PE, Darszon A, Treviño CL. Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan 19;86(1):1-14. doi: 10.1095/biolreprod.111.094037. Print 2012 Jan. PubMed PMID: 21976599; PubMed Central PMCID: PMC3313665. 10: Lai Y, Ma L, Huang W, Yu X, Zhang Y, Ji H, Tian J. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7349-53. doi: 10.1016/j.bmcl.2010.10.056. Epub 2010 Oct 20. PubMed PMID: 21055929. 11: Best L, Brown PD, Sener A, Malaisse WJ. Opposing effects of tenidap on the volume-regulated anion channel and K(ATP) channel activity in rat pancreatic beta-cells. Eur J Pharmacol. 2010 Mar 10;629(1-3):159-63. doi: 10.1016/j.ejphar.2009.12.013. Epub 2009 Dec 24. PubMed PMID: 20035738. 12: Perry C, Baker OJ, Reyland ME, Grichtchenko II. PKC{alpha}{beta}{gamma}- and PKC{delta}-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1409-23. doi: 10.1152/ajpcell.00028.2009. Epub 2009 Sep 25. PubMed PMID: 19783762; PubMed Central PMCID: PMC2793054. 13: Bulur N, Virreira M, Soyfoo MS, Louchami K, Delporte C, Perret J, Beauwens R, Malaisse WJ, Sener A. Expression of the electrogenic Na+-HCO3--cotransporter NBCe1 in tumoral insulin-producing BRIN-BD11 cells. Cell Physiol Biochem. 2009;24(3-4):187-92. doi: 10.1159/000233257. Epub 2009 Aug 3. PubMed PMID: 19710533. 14: Sussman CR, Zhao J, Plata C, Lu J, Daly C, Angle N, DiPiero J, Drummond IA, Liang JO, Boron WF, Romero MF, Chang MH. Cloning, localization, and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish. Am J Physiol Cell Physiol. 2009 Oct;297(4):C865-75. doi: 10.1152/ajpcell.00679.2008. Epub 2009 Jul 22. PubMed PMID: 19625604; PubMed Central PMCID: PMC2770747. 15: Soyfoo MS, Bulur N, Virreira M, Louchami K, Lybaert P, Crutzen R, Perret J, Delporte C, Roussa E, Thevenod F, Best L, Yates AP, Malaisse WJ, Sener A, Beauwens R. Expression of the electrogenic Na+-HCO3--cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells. Endocrine. 2009 Jun;35(3):449-58. doi: 10.1007/s12020-009-9175-1. Epub 2009 Apr 18. PubMed PMID: 19381888. 16: Uchiyama H, Hayashi H, Tanji K, Sugimoto O, Suzuki Y. pH stat studies on bicarbonate secretion in the isolated mouse ileum. Biomed Res. 2007 Oct;28(5):239-46. PubMed PMID: 18000336. 17: Haynes DR, Hutchens MJ, Whitehouse MW, Vernon-Roberts B. A comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats. Inflammopharmacology. 1998;6(3):193-202. PubMed PMID: 17657619. 18: Radwan MA, Ragab EA, Sabry NM, El-Shenawy SM. Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents. Bioorg Med Chem. 2007 Jun 1;15(11):3832-41. Epub 2007 Mar 13. PubMed PMID: 17395469. 19: Lu J, Boron WF. 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