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MedKoo Cat#: 599197 | Name: X 14868A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

X 14868A, also known as Maduramicin, is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is cytotoxic against Cryptosporidium spp. and is commonly used in veterinary medicine as an anti-coccidial agent. Maduramicin is also cytotoxic against Plasmodium gametocytes and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050.

Chemical Structure

X 14868A
X 14868A
CAS#79356-08-4

Theoretical Analysis

MedKoo Cat#: 599197

Name: X 14868A

CAS#: 79356-08-4

Chemical Formula: C47H80O17

Exact Mass: 916.5396

Molecular Weight: 917.14

Elemental Analysis: C, 61.55; H, 8.79; O, 29.66

Price and Availability

Size Price Availability Quantity
5mg USD 450.00
25mg USD 1,050.00
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Related CAS #
No Data
Synonym
X 14868A; X-14868A; X14868A;
IUPAC/Chemical Name
2-((2S,3S,4S,5R,6S)-6-((R)-1-((2R,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'S)-3'-(((2R,4S,5S,6S)-4,5-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5'-((2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-2-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-2-hydroxy-4,5-dimethoxy-3-methyltetrahydro-2H-pyran-2-yl)acetic acid
InChi Key
RWVUEZAROXKXRT-YBHBXVTESA-N
InChi Code
InChI=1S/C47H80O17/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50)/t23-,24+,25+,26+,27-,28-,29-,30-,31-,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45-,46+,47-/m0/s1
SMILES Code
O=C(O)C[C@]([C@H]1C)(O)O[C@@H]([C@@H]([C@@H]2[C@H](C)[C@@H](O)C[C@]3(CC[C@@]([C@@H]4O[C@@](C)(CC4)[C@H]5[C@H](C[C@H](O5)[C@@H]6[C@@H](C)C[C@@H](C)[C@](O)(C)O6)O[C@H]7O[C@@H](C)[C@H](OC)[C@@H](OC)C7)(C)O3)O2)C)[C@H](OC)[C@H]1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 917.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu CM, Hermann TE, Downey A, Prosser BL, Schildknecht E, Palleroni NJ, Westley JW, Miller PA. Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing culture. J Antibiot (Tokyo). 1983 Apr;36(4):343-50. PubMed PMID: 6853364.