IND8 | CAS#1778682-59-9 | α7-nAChR agonist

MedKoo Cat#: 563640 | Name: IND8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IND8 is a selective and potent α7-nAChR agonist.

Chemical Structure

IND8

CAS#1778682-59-9

Theoretical Analysis

MedKoo Cat#: 563640

Name: IND8

CAS#: 1778682-59-9

Chemical Formula: C17H19N5

Exact Mass: 293.1640

Molecular Weight: 293.37

Elemental Analysis: C, 69.60; H, 6.53; N, 23.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IND8; IND-8; IND 8;

IUPAC/Chemical Name

3-(4-(1H-indol-5-yl)-1H-1,2,3-triazol-1-yl)quinuclidine

InChi Key

FBFVECUFQXIPMF-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H19N5/c1-2-15-14(3-6-18-15)9-13(1)16-10-22(20-19-16)17-11-21-7-4-12(17)5-8-21/h1-3,6,9-10,12,17-18H,4-5,7-8,11H2

SMILES Code

C12=C(NC=C2)C=CC(C3=CN(C4CN5CCC4CC5)N=N3)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 293.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Khanduja S, Ghoshal U, Ghoshal UC. Phylogenetic analysis of genetically distinct Enterocytozoon bieneusi infecting renal transplant recipients. Acta Parasitol. 2017 Mar 1;62(1):63-68. doi: 10.1515/ap-2017-0007. PubMed PMID: 28030354. 2: Arunrungvichian K, Boonyarat C, Fokin VV, Taylor P, Vajragupta O. Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors. ACS Chem Neurosci. 2015 Aug 19;6(8):1331-40. doi: 10.1021/acschemneuro.5b00059. Epub 2015 May 15. PubMed PMID: 25978789. 3: Vijayaraghavan P, Prakash Vincent SG. Medium optimization for the production of fibrinolytic enzyme by Paenibacillus sp. IND8 using response surface methodology. ScientificWorldJournal. 2014 Jan 9;2014:276942. doi: 10.1155/2014/276942. eCollection 2014. PubMed PMID: 24523635; PubMed Central PMCID: PMC3913018. 4: Hsieh KH, LaHann TR, Speth RC. Topographic probes of angiotensin and receptor: potent angiotensin II agonist containing diphenylalanine and long-acting antagonists containing biphenylalanine and 2-indan amino acid in position 8. J Med Chem. 1989 Apr;32(4):898-903. PubMed PMID: 2704034.