pythiDC | CAS#1821370-71-1 | hydroxylase inhibitor

MedKoo Cat#: 563631 | Name: pythiDC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PythiDC is a selective inhibitor of collagen prolyl 4-hydroxylase, neither causing general toxicity nor disrupting iron homeostasis.

Chemical Structure

pythiDC

CAS#1821370-71-1

Theoretical Analysis

MedKoo Cat#: 563631

Name: pythiDC

CAS#: 1821370-71-1

Chemical Formula: C10H6N2O4S

Exact Mass: 250.0048

Molecular Weight: 250.23

Elemental Analysis: C, 48.00; H, 2.42; N, 11.20; O, 25.58; S, 12.81

Price and Availability

Size	Price	Availability
5mg	USD 110.00	Ready to Ship
10mg	USD 180.00	Ready to ship
25mg	USD 385.00	Ready to Ship
100mg	USD 650.00	Ready to Ship
200mg	USD 1,125.00	Ready to ship
500mg	USD 2,390.00	Ready to ship

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Related CAS #

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Synonym

pythiDC; pythi-DC; pythi DC;

IUPAC/Chemical Name

2-(5-Carboxythiazol-2-yl)pyridine-5-carboxylic acid

InChi Key

ISYUGJYTQIZJHV-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H6N2O4S/c13-9(14)5-1-2-6(11-3-5)8-12-4-7(17-8)10(15)16/h1-4H,(H,13,14)(H,15,16)

SMILES Code

O=C(C1=CN=C(C2=NC=C(C(O)=O)S2)C=C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#T23D03P28

QC Data

View QC data: current batch, Lot#T23D03P28

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

PythiDC is a selective collagen prolyl 4-hydroxylase (CP4H1) inhibitor with an IC50 value of 4.0 μM.

In vitro activity:

PythiDC decreased the malignant phenotypes of lung cancer cell lines in vitro. Reference: Transl Oncol. 2021 Aug;14(8):101128. https://pubmed.ncbi.nlm.nih.gov/34049151/

In vivo activity:

PythiDC treatment of colorectal cancer patient-derived xenografts that exhibited high expression of P4HA1 resulted in tumor regression. P4HA1 contributes to colorectal cancer progression and metastasis and that targeting P4HA1 with pythiDC could be an effective therapeutic strategy for aggressive colorectal cancers. Reference: Transl Oncol. 2020 Apr;13(4):100754. https://pubmed.ncbi.nlm.nih.gov/32199274/

	Solvent	mg/mL	mM
Solubility
	DMSO	4.9	19.58

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 250.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Robinson AD, Chakravarthi BVSK, Agarwal S, Chandrashekar DS, Davenport ML, Chen G, Manne U, Beer DG, Edmonds MD, Varambally S. Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Transl Oncol. 2021 Aug;14(8):101128. doi: 10.1016/j.tranon.2021.101128. Epub 2021 May 25. PMID: 34049151; PMCID: PMC8170159. 2. Agarwal S, Behring M, Kim HG, Bajpai P, Chakravarthi BVSK, Gupta N, Elkholy A, Al Diffalha S, Varambally S, Manne U. Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model. Transl Oncol. 2020 Apr;13(4):100754. doi: 10.1016/j.tranon.2020.100754. Epub 2020 Mar 18. Erratum in: Transl Oncol. 2021 Nov;14(11):101142. PMID: 32199274; PMCID: PMC7082635.

In vitro protocol:

In vivo protocol:

1. Agarwal S, Behring M, Kim HG, Bajpai P, Chakravarthi BVSK, Gupta N, Elkholy A, Al Diffalha S, Varambally S, Manne U. Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model. Transl Oncol. 2020 Apr;13(4):100754. doi: 10.1016/j.tranon.2020.100754. Epub 2020 Mar 18. Erratum in: Transl Oncol. 2021 Nov;14(11):101142. PMID: 32199274; PMCID: PMC7082635.

Robinson AD, Chakravarthi BVSK, Agarwal S, Chandrashekar DS, Davenport ML, Chen G, Manne U, Beer DG, Edmonds MD, Varambally S. Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma. Transl Oncol. 2021 Aug;14(8):101128. doi: 10.1016/j.tranon.2021.101128. Epub 2021 May 25. PMID: 34049151; PMCID: PMC8170159. Molecule Inhibitor in a Colorectal Cancer PDX Model. Transl Oncol. 2020 Apr;13(4):100754. doi: 10.1016/j.tranon.2020.100754. Epub 2020 Mar 18. Erratum in: Transl Oncol. 2021 Nov;14(11):101142. doi: 10.1016/j.tranon.2021.101142. PMID: 32199274; PMCID: PMC7082635.