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MedKoo Cat#: 563630 | Name: Aloenin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aloenin is a moderate inhibitor of BACE and competitive inhibitor of pancreatic lipase in vitro and in silico. It is derived from aloe vera and displays anti-hyperlipidemic activity.

Chemical Structure

Aloenin
CAS#38412-46-3

Theoretical Analysis

MedKoo Cat#: 563630

Name: Aloenin

CAS#: 38412-46-3

Chemical Formula: C19H22O10

Exact Mass: 410.1213

Molecular Weight: 410.37

Elemental Analysis: C, 55.61; H, 5.40; O, 38.99

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Aloenin;
IUPAC/Chemical Name
6-[4-Hydroxy-2-methyl-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-4-methoxypyran-2-one
InChi Key
KFJNVVJUICKJEQ-LQDZTQBFSA-N
InChi Code
InChI=1S/C19H22O10/c1-8-3-9(21)4-11(15(8)12-5-10(26-2)6-14(22)27-12)28-19-18(25)17(24)16(23)13(7-20)29-19/h3-6,13,16-21,23-25H,7H2,1-2H3/t13-,16-,17+,18-,19-/m1/s1
SMILES Code
O=C1C=C(OC)C=C(C2=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2C)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lucini L, Pellizzoni M, Pellegrino R, Molinari GP, Colla G. Phytochemical constituents and in vitro radical scavenging activity of different Aloe species. Food Chem. 2015 Mar 1;170:501-7. doi: 10.1016/j.foodchem.2014.08.034. Epub 2014 Aug 27. PubMed PMID: 25306376. 2: Zhong JS, Wan JZ, Ding WJ, Wu XF, Xie ZY. One-step separation and purification of two chromones and one pyrone from Aloe barbadensis Miller: a comparison between reversed-phase flash chromatography and high-speed counter current chromatography. Phytochem Anal. 2014 May-Jun;25(3):282-8. doi: 10.1002/pca.2504. Epub 2014 Feb 5. PubMed PMID: 24497404. 3: Zhong J, Huang Y, Ding W, Wu X, Wan J, Luo H. Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D. Fitoterapia. 2013 Dec;91:159-165. doi: 10.1016/j.fitote.2013.08.027. Epub 2013 Sep 9. PubMed PMID: 24028970. 4: Wu XF, Wan JZ, Luo BJ, Yang MR, Ding WJ, Zhong JS. [A novel naphthalene derivative from Aloe barbadensis]. Yao Xue Xue Bao. 2013 May;48(5):723-7. Chinese. PubMed PMID: 23888696. 5: Abd-Alla HI, Abu-Gabal NS, Hassan AZ, El-Safty MM, Shalaby NM. Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents. Arch Pharm Res. 2012 Aug;35(8):1347-54. doi: 10.1007/s12272-012-0804-5. Epub 2012 Sep 1. PubMed PMID: 22941477. 6: Abd-Alla HI, Shaaban M, Shaaban KA, Abu-Gabal NS, Shalaby NM, Laatsch H. New bioactive compounds from Aloe hijazensis. Nat Prod Res. 2009;23(11):1035-49. doi: 10.1080/14786410802242851. PubMed PMID: 19521919. 7: Mizuuchi Y, Shi SP, Wanibuchi K, Kojima A, Morita H, Noguchi H, Abe I. Novel type III polyketide synthases from Aloe arborescens. FEBS J. 2009 Apr;276(8):2391-401. PubMed PMID: 19348024. 8: Yokohira M, Matsuda Y, Suzuki S, Hosokawa K, Yamakawa K, Hashimoto N, Saoo K, Nabae K, Doi Y, Kuno T, Imaida K. Equivocal colonic carcinogenicity of Aloe arborescens Miller var. natalensis berger at high-dose level in a Wistar Hannover rat 2-y study. J Food Sci. 2009 Mar;74(2):T24-30. doi: 10.1111/j.1750-3841.2009.01070.x. PubMed PMID: 19323775. 9: Gutterman Y, Chauser-Volfson E. The content of secondary phenol metabolites in pruned leaves of Aloe arborescens, a comparison between two methods: leaf exudates and leaf water extract. J Nat Med. 2008 Oct;62(4):430-5. doi: 10.1007/s11418-008-0252-1. Epub 2008 May 10. PubMed PMID: 18470597. 10: Gao B, Yao CS, Zhou JY, Chen RY, Fang WS. [Active constituents from Aloe arborescens as BACE inhibitors]. Yao Xue Xue Bao. 2006 Oct;41(10):1000-3. Chinese. PubMed PMID: 17184120. 11: Beppu H, Shimpo K, Chihara T, Kaneko T, Tamai I, Yamaji S, Ozaki S, Kuzuya H, Sonoda S. Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. J Ethnopharmacol. 2006 Feb 20;103(3):468-77. Epub 2006 Jan 6. PubMed PMID: 16406411. 12: Jin GZ, Quan HJ, Koyanagi J, Takeuchi K, Miura Y, Komada F, Saito S. 4'-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells. Cancer Lett. 2005 Jan 31;218(1):15-20. PubMed PMID: 15639336. 13: Durì L, Morelli CF, Crippa S, Speranza G. 6-Phenylpyrones and 5-methylchromones from Kenya aloe. Fitoterapia. 2004 Jul;75(5):520-2. PubMed PMID: 15261393. 14: Kodym A, Marcinkowski A, Kukuła H. Technology of eye drops containing aloe (Aloe arborescens Mill.--Liliaceae) and eye drops containing both aloe and neomycin sulphate. Acta Pol Pharm. 2003 Jan-Feb;60(1):31-9. PubMed PMID: 12848365. 15: Rebecca W, Kayser O, Hagels H, Zessin KH, Madundo M, Gamba N. The phytochemical profile and identification of main phenolic compounds from the leaf exudate of Aloe secundiflora by high-performance liquid chromatography-mass spectroscopy. Phytochem Anal. 2003 Mar-Apr;14(2):83-6. PubMed PMID: 12693631. 16: Shen Z, Li J, Hu Z. [Distribution of anthraquinones in leaves of two Aloe species and their defence strategy]. Ying Yong Sheng Tai Xue Bao. 2002 Nov;13(11):1381-4. Chinese. PubMed PMID: 12624988. 17: Kodym A, Bujak T. Physicochemical and microbiological properties as well as stability of ointments containing aloe extract (Aloe arborescens Mill.) or aloe extract associated to neomycin sulphate. Pharmazie. 2002 Dec;57(12):834-7. PubMed PMID: 12561247. 18: Kodym A, Grześkowiak E, Partyka D, Marcinkowski A, Kaczyńska-Dyba E. Biopharmaceutical assessment of eye drops containing aloe (Aloe arborescens Mill.) and neomycin sulphate. Acta Pol Pharm. 2002 May-Jun;59(3):181-6. PubMed PMID: 12230244. 19: Shimpo K, Ida C, Chihara T, Beppu H, Kaneko T, Kuzuya H. Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin. Phytother Res. 2002 Aug;16(5):491-3. PubMed PMID: 12203274. 20: Kuzuya H, Tamai I, Beppu H, Shimpo K, Chihara T. Determination of aloenin, barbaloin and isobarbaloin in aloe species by micellar electrokinetic chromatography. J Chromatogr B Biomed Sci Appl. 2001 Mar 5;752(1):91-7. PubMed PMID: 11254203.