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MedKoo Cat#: 599144 | Name: Locoid C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Locoid C is a new combination anti-inflammatory drug that contains hydrocortisone 17-butyrate & chlorquinaldol.

Chemical Structure

Locoid C
Locoid C
CAS#135467-84-4

Theoretical Analysis

MedKoo Cat#: 599144

Name: Locoid C

CAS#: 135467-84-4

Chemical Formula: C35H43Cl2NO7

Exact Mass:

Molecular Weight: 660.62

Elemental Analysis: C, 63.63; H, 6.56; Cl, 10.73; N, 2.12; O, 16.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Locoid C;
IUPAC/Chemical Name
(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate compound with 5,7-dichloro-2-methylquinolin-8-ol (1:1)
InChi Key
MAFGBWPMBVXVNI-PVHZEMNUSA-N
InChi Code
InChI=1S/C25H36O6.C10H7Cl2NO/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3;1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3;2-4,14H,1H3/t17-,18-,19-,22+,23-,24-,25-;/m0./s1
SMILES Code
C[C@@]12[C@](C(CO)=O)(OC(CCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O.OC5=C6N=C(C)C=CC6=C(Cl)C=C5Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 660.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meenan FO. A double-blind comparative study to compare the efficacy of Locoid C with Tri-Adcortyl in children with infected eczema. Br J Clin Pract. 1988 May;42(5):200-2. PubMed PMID: 2463849. 2: Straehl B. [Assessment of a new combination drug (locoid-c) for the local treatment of inflammatory dermatoses in a dermatological practice (author's transl)]. Schweiz Rundsch Med Prax. 1978 Oct 3;67(40):1478-80. German. PubMed PMID: 704539.