MedKoo Cat#: 599128 | Name: Tnrnflrfamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tnrnflrfamide is a SCP (small cardioactive peptide)-like peptide found in lobster neurons; exhibits FMRFamide-like immunoreactivity.

Chemical Structure

Tnrnflrfamide
CAS#113611-68-0

Theoretical Analysis

MedKoo Cat#: 599128

Name: Tnrnflrfamide

CAS#: 113611-68-0

Chemical Formula: C48H75N17O11

Exact Mass: 1065.5832

Molecular Weight: 1066.23

Elemental Analysis: C, 54.07; H, 7.09; N, 22.33; O, 16.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Tnrnflrfamide; Lobster peptide F1; F1 Peptide, lobster; Peptide F(1), lobster; Thr-asn-arg-asn-phe-leu-arg-phe-NH2;
IUPAC/Chemical Name
(S)-N1-((S)-1-(((S)-1-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((S)-4-amino-2-((2S,3R)-2-amino-3-hydroxybutanamido)-4-oxobutanamido)-5-guanidinopentanamido)succinamide
InChi Key
YAUWLGCATULGNL-KNECAJLFSA-N
InChi Code
InChI=1S/C48H75N17O11/c1-25(2)20-32(42(72)59-29(16-10-18-57-47(53)54)40(70)61-31(39(52)69)21-27-12-6-4-7-13-27)62-43(73)33(22-28-14-8-5-9-15-28)63-45(75)34(23-36(49)67)64-41(71)30(17-11-19-58-48(55)56)60-44(74)35(24-37(50)68)65-46(76)38(51)26(3)66/h4-9,12-15,25-26,29-35,38,66H,10-11,16-24,51H2,1-3H3,(H2,49,67)(H2,50,68)(H2,52,69)(H,59,72)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,76)(H4,53,54,57)(H4,55,56,58)/t26-,29+,30+,31+,32+,33+,34+,35+,38+/m1/s1
SMILES Code
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,066.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weimann JM, Marder E, Evans B, Calabrese RL. The effects of SDRNFLRFamide and TNRNFLRFamide on the motor patterns of the stomatogastric ganglion of the crab Cancer borealis. J Exp Biol. 1993 Aug;181:1-26. PubMed PMID: 8409825. 2: Jorge-Rivera JC, Marder E. TNRNFLRFamide and SDRNFLRFamide modulate muscles of the stomatogastric system of the crab Cancer borealis. J Comp Physiol A. 1996 Dec;179(6):741-51. PubMed PMID: 8956495. 3: Jorge-Rivera JC, Sen K, Birmingham JT, Abbott LF, Marder E. Temporal dynamics of convergent modulation at a crustacean neuromuscular junction. J Neurophysiol. 1998 Nov;80(5):2559-70. PubMed PMID: 9819263. 4: Arbiser ZK, Beltz BS. SCPB-and FMRFamide-like immunoreactivities in lobster neurons: colocalization of distinct peptides or colabeling of the same peptide(s)? J Comp Neurol. 1991 Apr 15;306(3):417-24. PubMed PMID: 1865002. 5: Groome JR, Townley MA, Watson WH 3rd. Excitatory actions of FMRFamide-related peptides (FaRPs) on the neurogenic Limulus heart. Biol Bull. 1994 Jun;186(3):309-18. PubMed PMID: 8043656. 6: Swensen AM, Marder E. Modulators with convergent cellular actions elicit distinct circuit outputs. J Neurosci. 2001 Jun 1;21(11):4050-8. PubMed PMID: 11356892. 7: Fort TJ, Brezina V, Miller MW. Regulation of the crab heartbeat by FMRFamide-like peptides: multiple interacting effects on center and periphery. J Neurophysiol. 2007 Nov;98(5):2887-902. Epub 2007 Sep 5. PubMed PMID: 17804580. 8: Birmingham JT, Billimoria CP, DeKlotz TR, Stewart RA, Marder E. Differential and history-dependent modulation of a stretch receptor in the stomatogastric system of the crab, Cancer borealis. J Neurophysiol. 2003 Dec;90(6):3608-16. Epub 2003 Aug 27. PubMed PMID: 12944539. 9: Swensen AM, Marder E. Multiple peptides converge to activate the same voltage-dependent current in a central pattern-generating circuit. J Neurosci. 2000 Sep 15;20(18):6752-9. PubMed PMID: 10995818. 10: Verley DR, Doan V, Trieu Q, Messinger DI, Birmingham JT. Characteristic differences in modulation of stomatogastric musculature by a neuropeptide in three species of Cancer crabs. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008 Oct;194(10):879-86. doi: 10.1007/s00359-008-0359-6. Epub 2008 Aug 22. PubMed PMID: 18719922. 11: Cruz-Bermúdez ND, Fu Q, Kutz-Naber KK, Christie AE, Li L, Marder E. Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer. J Neurochem. 2006 May;97(3):784-99. Epub 2006 Mar 3. PubMed PMID: 16515542. 12: Mousley A, Marks NJ, Halton DW, Geary TG, Thompson DP, Maule AG. Arthropod FMRFamide-related peptides modulate muscle activity in helminths. Int J Parasitol. 2004 May;34(6):755-68. PubMed PMID: 15111097. 13: Moulis A. RFamide neuropeptide actions on the molluscan heart. Acta Biol Hung. 2004;55(1-4):335-41. PubMed PMID: 15270250. 14: Worden MK, Kravitz EA, Goy MF. Peptide F1, an N-terminally extended analog of FMRFamide, enhances contractile activity in multiple target tissues in lobster. J Exp Biol. 1995 Jan;198(Pt 1):97-108. PubMed PMID: 7891041. 15: Mercier AJ, Russenes RT. Modulation of Crayfish Hearts by FMRFamide-related Peptides. Biol Bull. 1992 Jun;182(3):333-340. doi: 10.2307/1542253. PubMed PMID: 29304596. 16: Li L, Kelley WP, Billimoria CP, Christie AE, Pulver SR, Sweedler JV, Marder E. Mass spectrometric investigation of the neuropeptide complement and release in the pericardial organs of the crab, Cancer borealis. J Neurochem. 2003 Nov;87(3):642-56. PubMed PMID: 14535947. 17: Combes D, Simmers J, Moulins M. Conditional dendritic oscillators in a lobster mechanoreceptor neurone. J Physiol. 1997 Feb 15;499 ( Pt 1):161-77. PubMed PMID: 9061647; PubMed Central PMCID: PMC1159344. 18: Wilkens JL, Taylor HH. The control of vascular resistance in the southern rock lobster, Jasus edwardsii (Decapoda: Palinuridae). Comp Biochem Physiol A Mol Integr Physiol. 2003 Jul;135(3):369-76. PubMed PMID: 12829045. 19: McGaw IJ, McMahon BR. The FMRFamide-related peptides F1 and F2 alter hemolymph distribution and cardiac output in the crab Cancer magister. Biol Bull. 1995 Apr;188(2):186-96. PubMed PMID: 7742390.