Synonym
Lnd 623; Lnd-623; Lnd623;
IUPAC/Chemical Name
(2R,3R,4R,5R,6S)-2-(((3R,5S,8R,9S,10S,13R,14R,17S)-14-amino-17-((R)-1-hydroxyethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
InChi Key
RHGPTBMIKFUPQA-QXTIEUCESA-N
InChi Code
InChI=1S/C27H47NO6/c1-14(29)18-9-12-27(28)20-6-5-16-13-17(34-24-23(32)22(31)21(30)15(2)33-24)7-10-25(16,3)19(20)8-11-26(18,27)4/h14-24,29-32H,5-13,28H2,1-4H3/t14-,15+,16+,17-,18-,19+,20-,21+,22-,23-,24+,25+,26-,27-/m1/s1
SMILES Code
O[C@H]([C@@H]([C@H]([C@H](C)O1)O)O)[C@@H]1O[C@@H]2CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](O)C)CC[C@@]5(N)[C@]4([H])CC[C@@]3([H])C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
481.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jarreau FX, Koenig JJ, Fenard S. A new inotropic aminosteroid: LND 623. Eur Heart J. 1984 Dec;5 Suppl F:309-14. PubMed PMID: 6549446.
2: Weissenburger J, Heckle J, Biour M, Poirier JM, Jarreau FX, Jaillon P, Cheymol G. Comparative hemodynamic study of a new aminosteroid: LND-623 with its 20 alpha-isomer: LND-369, and with digoxin and digoxigenin-rhamnoside in the anesthetized dog. Fundam Clin Pharmacol. 1989;3(1):67-78. PubMed PMID: 2653992.
3: Maixent JM, Berrebi-Bertrand I, Lelievre LG. Inhibition of cardiac (Na+, K+)-ATPase isozymes by LND 623. Biochem Pharmacol. 1991 Dec 11;42 Suppl:S223-4. PubMed PMID: 1662951.
4: Maixent JM, Lelièvre L, Berrebi-Bertrand I. Mechanism underlying the strong positive inotropic effects of LND-623: specific inhibition of Na, K-ATPase isoforms and exclusion of cellular sites of contractile control. Cardiovasc Drugs Ther. 1998 Dec;12(6):585-94. PubMed PMID: 10410828.
5: Adamantidis MM, Honoré ER, Dupuis BA. Electrical and mechanical effects of new aminosteroids on guinea-pig isolated ventricular muscle. Br J Pharmacol. 1988 Dec;95(4):1063-74. PubMed PMID: 2851356; PubMed Central PMCID: PMC1854287.
6: Maixent JM, Berrebi Bertrand I, Lelièvre LG, Fénard S. Efficacy and safety of the novel Na+,K(+)-ATPase inhibitor 20R 14 beta-amino 3 beta-rhamnosyl 5 beta-pregnan 20 beta-ol in a dog model of heart failure. Arzneimittelforschung. 1992 Nov;42(11):1301-5. PubMed PMID: 1337248.
7: Brown L. Positive inotropic and vasoconstrictor responses to 14 beta-aminopregnane derivatives in isolated tissues from the guinea-pig. Clin Exp Pharmacol Physiol. 1990 Aug;17(8):589-94. PubMed PMID: 2208801.
8: Smyth DD, Templeton JF, Sashi Kumar VP, Yan Y, Widajewicz W, LaBella FS. Digitaloid pregnanes promote potassium-sparing diuresis in the guinea pig. Can J Physiol Pharmacol. 1992 May;70(5):723-7. PubMed PMID: 1423016.
