Synonym
LM 985; LM-985; LM985; NSC 293015; NSC-293015; NSC293015;
IUPAC/Chemical Name
2-(diethylamino)ethyl 2-(4-oxo-2-phenyl-4H-chromen-8-yl)acetate
InChi Key
ZMLZQKCBYPEYMG-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H25NO4/c1-3-24(4-2)13-14-27-22(26)15-18-11-8-12-19-20(25)16-21(28-23(18)19)17-9-6-5-7-10-17/h5-12,16H,3-4,13-15H2,1-2H3
SMILES Code
O=C(OCCN(CC)CC)CC1=C2C(C(C=C(C3=CC=CC=C3)O2)=O)=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
379.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bibby MC, Double JA. Flavone acetic acid--from laboratory to clinic and back. Anticancer Drugs. 1993 Feb;4(1):3-17. Review. PubMed PMID: 8457711.
2: Plowman J, Narayanan VL, Dykes D, Szarvasi E, Briet P, Yoder OC, Paull KD. Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treat Rep. 1986 May;70(5):631-5. PubMed PMID: 3708611.
3: Dodion PF, Abrams J, Gérard B, Crespeigne N, Peeters B, Van Berchem C, Kenis Y. Clinical and pharmacokinetic phase I trial with the diethylaminoester of flavone acetic acid (LM985, NSC 293015). Eur J Cancer Clin Oncol. 1987 Jun;23(6):837-42. PubMed PMID: 3653200.
4: Double JA, Bibby MC, Loadman PM. Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. Br J Cancer. 1986 Oct;54(4):595-600. PubMed PMID: 3778803; PubMed Central PMCID: PMC2001488.
5: Bibby MC, Double JA, Phillips RM, Loadman PM. Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). Br J Cancer. 1987 Feb;55(2):159-63. PubMed PMID: 3814485; PubMed Central PMCID: PMC2002093.
6: Kerr DJ, Kaye SB, Graham J, Cassidy J, Harding M, Setanoians A, McGrath JC, Vezin WR, Cunningham D, Forrest G, et al. Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). Cancer Res. 1986 Jun;46(6):3142-6. PubMed PMID: 3698028.
7: Schroyens WA, Dodion PF, Sanders C, Loos M, Dethier NE, Delforge AR, Stryckmans PA, Kenis Y. In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). Eur J Cancer Clin Oncol. 1987 Aug;23(8):1135-9. PubMed PMID: 3653209.
