Synonym
Viquidil; LM 192; LM-192; LM-192; Viquidilum;
IUPAC/Chemical Name
1-(6-methoxyquinolin-4-yl)-3-(3-vinylpiperidin-4-yl)propan-1-one
InChi Key
DKRSEIPLAZTSFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24N2O2/c1-3-14-13-21-10-8-15(14)4-7-20(23)17-9-11-22-19-6-5-16(24-2)12-18(17)19/h3,5-6,9,11-12,14-15,21H,1,4,7-8,10,13H2,2H3
SMILES Code
O=C(C1=CC=NC2=CC=C(OC)C=C12)CCC3C(C=C)CNCC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Guérémy C, Uzan A, Tamen JC. [Viquidil: study of metabolism using the isotope method. I. Synthesis of 14C-labelled viquidil]. Arzneimittelforschung. 1972 Aug;22(8):1336-40. French. PubMed PMID: 4678396.
2: De Valois JC. Increase in cerebral blood flow in the rabbit by viquidil. Stroke. 1973 Mar-Apr;4(2):218-20. PubMed PMID: 4702310.
3: Hünermann B, Felix R, Wesener K, Winkler C. [Effect of Viquidil on cerebral circulation. Studies using a scintillation camera-computer system]. Arzneimittelforschung. 1973 Aug;23(8):1074-6. German. PubMed PMID: 4801028.
4: Boudouresques J, Gosset A. [Treatment of vascular diseases of the nervous system with Viquidil hydrochloride]. Mars Med. 1972;109(6):453-6. French. PubMed PMID: 4563604.
5: Uzan A, Guérémy C. [Viquidil: study of its metabolism by an isotopic method. 3. Excretion and biotransformation in animals]. Arzneimittelforschung. 1974 Jan;24(1):34-9. French. PubMed PMID: 4406106.
6: Uzan A, Guérémy C. [Viquidil: study of metabolism using the isotope method. II. Absorption and distribution of 14C-labelled viquidil in animals]. Arzneimittelforschung. 1972 Aug;22(8):1341-6. French. PubMed PMID: 4678397.
7: Sim AK, Uzan A. The antithrombotic activity of viquidil, a cerebral vasodilator. Arzneimittelforschung. 1979;29(3):508-11. PubMed PMID: 582736.
8: Cosnier D, Cheucle M, Rispat G, Streichenberger G. Influence of hypercapnia on the cerebrovascular activities of some drugs used in the treatment of cerebral ischemia. Arzneimittelforschung. 1977;27(8):1566-9. PubMed PMID: 578747.
9: Cargnelli G, Finotti P, Melacini P, Ferrari M. [Effects of viquidil on the electric and mechanical activity of smooth muscle]. Boll Soc Ital Biol Sper. 1976 Nov 15;52(21):1808-13. Italian. PubMed PMID: 1037429.
10: Lecrubier C, Uzan A, Samama M. [Effect of a new cerebral vasodilator agent, viquidil, on the aggregation of blood platelets]. Arzneimittelforschung. 1972 Aug;22(8):1334-6. French. PubMed PMID: 4678395.
11: N'Diaye IP, Girard PL, Dumas M. [Trial of a new cerebral vasoregulator: viquidil hydrochloride, in black Africans]. Bull Soc Med Afr Noire Lang Fr. 1974;19(3):257-9. French. PubMed PMID: 4457255.
12: Lebiediewa NW. [Current treatment of cerebrovascular disorder with vasoactive drugs]. Neurol Neurochir Pol. 1981 Jul-Aug;15(4):417-21. Polish. PubMed PMID: 6895779.
13: Nihard P. [Does fluororetinography permit evaluation of the action of drugs: myth or reality?]. Bull Soc Belge Ophtalmol. 1981;192:93-102. French. PubMed PMID: 6896665.
14: Nowicki JP, MacKenzie ET, Spinnewyn B. Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondria. J Cereb Blood Flow Metab. 1982;2(1):33-40. PubMed PMID: 7061602.
