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MedKoo Cat#: 599063 | Name: Tiadenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiadenol is a Hypolipidemic Agent.

Chemical Structure

Tiadenol
Tiadenol
CAS#6964-20-1

Theoretical Analysis

MedKoo Cat#: 599063

Name: Tiadenol

CAS#: 6964-20-1

Chemical Formula: C14H30O2S2

Exact Mass: 294.1687

Molecular Weight: 294.51

Elemental Analysis: C, 57.10; H, 10.27; O, 10.86; S, 21.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tiadenol; LL 1558; LL-1558; LL1558 NSC 66316; NSC-66316; NSC66316; Tiadenolum;
IUPAC/Chemical Name
2,2'-(decane-1,10-diylbis(sulfanediyl))bis(ethan-1-ol)
InChi Key
WRCITXQNXAIKLR-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H30O2S2/c15-9-13-17-11-7-5-3-1-2-4-6-8-12-18-14-10-16/h15-16H,1-14H2
SMILES Code
OCCSCCCCCCCCCCSCCO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 294.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Maffei Facino R, Carini M, Tofanetti O. Carboxylic metabolites of tiadenol as "proximate" inducers of hepatic peroxisomal beta-oxidation activity. Pharmacol Res Commun. 1988 Apr;20(4):265-76. PubMed PMID: 3387457. 2: Gaion RM, Murari L, Cima L, Valenti P, Da Re P. Antilipolytic activity of tiadenol-nicotinate in isolated fat cells: a comparison with its parent drugs. Drugs Exp Clin Res. 1985;11(6):407-11. PubMed PMID: 3836137. 3: Maffei Facino R, Carini M, Tofanetti O, Casciarri I, Longoni E. Experimental studies on pharmacology, metabolism and toxicology with tiadenol-disulfoxide. Dissociation of lipid lowering effects and the induction of peroxisomal and microsomal drug-metabolizing enzymes. Arzneimittelforschung. 1987 Jun;37(6):682-91. PubMed PMID: 3663266. 4: Berge RK, Lillehaug JR. Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells. Int J Cancer. 1985 Oct 15;36(4):489-94. PubMed PMID: 2864317. 5: Mizuguchi H, Kudo N, Ohya T, Kawashima Y. Effects of tiadenol and di-(2-ethylhexyl)phthalate on the metabolism of phosphatidylcholine and phosphatidylethanolamine in the liver of rats: comparison with clofibric acid. Biochem Pharmacol. 1999 Apr 15;57(8):869-76. PubMed PMID: 10086319. 6: Mounie J, Goudonnet H, Bereksi-Reguig K, Escousse A, Truchot R. [Inducing effects of bis-hydroxyethylthio-1,10-decane (tiadenol) on hepatic microsomal enzymes of the rat]. J Pharmacol. 1983 Apr-Jun;14(2):171-82. French. PubMed PMID: 6408317. 7: Desager JP, Costermans J, Sclavons M, Harvengt C. The metabolic fate of 14C or 35S labelled tiadenol in rabbit after i.v. and oral administration. Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):225-32. PubMed PMID: 3816878. 8: Maffei Facino R, Carini M, Tofanetti O. Metabolism of the hypolipidemic agent tiadenol in man and in the rat. Arzneimittelforschung. 1986 Apr;36(4):722-8. PubMed PMID: 3718595. 9: Serra T, Gavelli MS, Vitaliano E, Santini G, Catalano A, Rossi FG, Tozzi J, Caridis R, Guarini G. [Therapy of hypercholesterolemia and hypertriglyceridemia. Comparison of the lipid-lowering effect of simvastatin and tiadenol]. Clin Ter. 1990 Mar 15;132(5):307-13. Italian. PubMed PMID: 2139833. 10: Accarino G, Barone L, Chieppa S, Giusti I, Nutile T, Luppino E, Visone C. [Experimental study of the hypolipidemic effect of tiadenol]. Boll Chim Farm. 1979 Dec;118(12):739-47. Italian. PubMed PMID: 552256. 11: Maffei Facino R, Carini M, Nava ML, Tofanetti O. Effects of chronic tiadenol administration on liver microsomal cytochrome P-450 and associated monooxygenases in the rat. Farmaco Prat. 1983 Dec;38(12):429-38. PubMed PMID: 6662218. 12: Franceschini G, Poli A, Catapano AL, Gatti E, Sirtori M, Gianfranceschi G, Sirtori CR. Pharmacological studies on tiadenol in type IV patients. Evidence for a mechanism of action different from other lipid-lowering drugs. Atherosclerosis. 1981 Nov-Dec;40(3-4):245-55. PubMed PMID: 7332603. 13: Kritchevsky D, Tepper SA, Czarnecki SK, Story JA. Influence of tiadenol, bis-(hydroxyethylthio)1,10-decane, on cholesterol metabolism in rats. Pharmacol Res Commun. 1979 Nov;11(10):861-7. PubMed PMID: 538065. 14: Vannini P, Ciavarella A, Motta R, Fiocchi M. [Tiadenol treatment of hyperlipoproteinemia in maturity onset diabetes]. G Clin Med. 1980 Sep;61(9):687-701. Italian. PubMed PMID: 7009295. 15: Kawashima Y, Uy-Yu N, Kozuka H. Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol. Biochem J. 1989 Nov 1;263(3):897-904. PubMed PMID: 2574572; PubMed Central PMCID: PMC1133515. 16: Modugno P. [Preventive use of tiadenol in pulmonary fat embolism in rabbits with multiple experimental fractures]. Arch Sci Med (Torino). 1982 Oct-Dec;139(4):419-24. Italian. PubMed PMID: 7168633. 17: Rozé C, Vaille C, Souchard M, De la Tour J, Debray C. [The action of tiadenol on compensatory hypertrophy of the liver in the rat]. Arch Int Pharmacodyn Ther. 1976 Jul;222(1):166-76. French. PubMed PMID: 984967. 18: Cuchet P, Morrier C, Cand F, Keriel C. Effects of clofibrate and tiadenol on the elimination of lipids and bile acids in rat bile. Lipids. 1981 Oct;16(10):732-8. PubMed PMID: 7300592. 19: Berge RK, Bakke OM. Changes in lipid metabolizing enzymes of hepatic subcellular fractions from rats treated with tiadenol and clofibrate. Biochem Pharmacol. 1981 Aug 15;30(16):2251-6. PubMed PMID: 7295339. 20: Sirtori M, Montanari G, Gianfranceschi G, Malacrida MG, Battistin P, Morazzoni G, Tremoli E, Colli S, Maderna P, Sirtori CR. Clofibrate and tiadenol treatment in hyperlipoproteinemias. A comparative trial of drugs affecting lipoprotein catabolism and biosynthesis. Atherosclerosis. 1983 Nov;49(2):149-61. PubMed PMID: 6365105.

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