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MedKoo Cat#: 599027 | Name: N-epsilon-Lithocholyllysine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-epsilon-Lithocholyllysine is a component of tissue-bound lithocholic acid.

Chemical Structure

N-epsilon-Lithocholyllysine
N-epsilon-Lithocholyllysine
CAS#65236-49-9

Theoretical Analysis

MedKoo Cat#: 599027

Name: N-epsilon-Lithocholyllysine

CAS#: 65236-49-9

Chemical Formula: C30H52N2O4

Exact Mass: 504.3927

Molecular Weight: 504.75

Elemental Analysis: C, 71.39; H, 10.38; N, 5.55; O, 12.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
N-epsilon-Lithocholyllysine; Lithocholyl-epsilon-L-lysine;
IUPAC/Chemical Name
N6-((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)-L-lysine
InChi Key
SOAQBBCJNVBHNR-FGUUPDTHSA-N
InChi Code
InChI=1S/C30H52N2O4/c1-19(7-12-27(34)32-17-5-4-6-26(31)28(35)36)23-10-11-24-22-9-8-20-18-21(33)13-15-29(20,2)25(22)14-16-30(23,24)3/h19-26,33H,4-18,31H2,1-3H3,(H,32,34)(H,35,36)/t19-,20-,21-,22+,23-,24+,25+,26+,29+,30-/m1/s1
SMILES Code
N[C@@H](CCCCNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 504.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nair PP, Kessie G, Flanagan VP. Reaffirmation of the validity of enzymatic cleavage of lithocholic acid from N-epsilon-lithocholyl-L-lysine and N-alpha-CBZ-N-epsilon-lithocholyl-L-lysine. J Lipid Res. 1986 Aug;27(8):905-9. PubMed PMID: 2877042. 2: Turjman N, Nair PP. Nature of tissue-bound lithocholic acid and its implications in the role of bile acids in carcinogenesis. Cancer Res. 1981 Sep;41(9 Pt 2):3761-3. PubMed PMID: 7020935. 3: Nair PP, Kessie G, Patnaik R, Guidry C. Isolation and HPLC of N-epsilon-lithocholyl lysine as its fluorescamine and dimethylaminoazobenzene isothiocyanate derivatives. Steroids. 1994 Mar;59(3):212-6. PubMed PMID: 8048154. 4: Nair PP, Kessie G, Turjman N. Synthesis of N-epsilon-lithocholyl-L-lysine, a component of tissue-bound lithocholic acid, via lithocholyl-N-hydroxysuccinimide. J Steroid Biochem. 1985 Nov;23(5A):573-6. PubMed PMID: 4079375. 5: Yanagisawa J, Akashi Y, Miyazaki H, Nakayama F. Critical evaluation of the existence of so-called tissue-bound lithocholate in human liver tissue by selected ion monitoring. J Lipid Res. 1984 Nov;25(11):1263-71. PubMed PMID: 6394682.

View History

ICI-193428

ICI-193428