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MedKoo Cat#: 563597 | Name: PK-14105

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PK-14105 is a selective peripheral-type cardiac benzodiazepine photoaffinity ligand.

Chemical Structure

PK-14105
PK-14105
CAS#107257-28-3

Theoretical Analysis

MedKoo Cat#: 563597

Name: PK-14105

CAS#: 107257-28-3

Chemical Formula: C21H20FN3O3

Exact Mass: 381.1489

Molecular Weight: 381.40

Elemental Analysis: C, 66.13; H, 5.29; F, 4.98; N, 11.02; O, 12.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PK-14105; PK 14105; PK14105;
IUPAC/Chemical Name
N-Butan-2-yl-1-(2-fluoro-5-nitrophenyl)-N-methylisoquinoline-3-carboxamide
InChi Key
GXXKDYZSBGOJQN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H20FN3O3/c1-4-13(2)24(3)21(26)19-11-14-7-5-6-8-16(14)20(23-19)17-12-15(25(27)28)9-10-18(17)22/h5-13H,4H2,1-3H3
SMILES Code
O=C(C1=CC2=C(C(C3=CC([N+]([O-])=O)=CC=C3F)=N1)C=CC=C2)N(C(CC)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamagishi H, Watanabe M, Yazaki K, Sawaki K, Kawaguchi M. Pharmacological characterization of an 18-kDa protein associated with the peripheral-type benzodiazepine receptor in salivary glands. Jpn J Pharmacol. 2000 Feb;82(2):110-5. PubMed PMID: 10877528. 2: Yeliseev AA, Krueger KE, Kaplan S. A mammalian mitochondrial drug receptor functions as a bacterial "oxygen" sensor. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5101-6. PubMed PMID: 9144197; PubMed Central PMCID: PMC24638. 3: Woods MJ, Zisterer DM, Williams DC. Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. Biochem Pharmacol. 1996 May 17;51(10):1283-92. PubMed PMID: 8787543. 4: Alenfall J, Batra S. Photoaffinity labeling of peripheral benzodiazepine receptors in R-3327 Dunning prostatic tumors. Biochem Pharmacol. 1996 Apr 26;51(8):1009-13. PubMed PMID: 8866822. 5: Blahos J 2nd, Whalin ME, Krueger KE. Identification and purification of a 10-kilodalton protein associated with mitochondrial benzodiazepine receptors. J Biol Chem. 1995 Sep 1;270(35):20285-91. PubMed PMID: 7657598. 6: Gimeno M, Pallás M, Newman AH, Camarasa J, Escubedo E. The role of cyclic nucleotides in the action of peripheral-type benzodiazepine receptor ligands in rat aorta. Gen Pharmacol. 1994 Dec;25(8):1553-61. PubMed PMID: 7721028. 7: Moynagh PN, Schousboe A, Williams DC. The peripheral-type benzodiazepine receptor is present in astrocytes but is not a primary site of action for convulsants/anticonvulsants. J Neurochem. 1994 Feb;62(2):673-9. PubMed PMID: 8294930. 8: Moynagh PN, Williams DC. Molecular studies on the peripheral-type benzodiazepine acceptor. Biochem Soc Trans. 1992 Aug;20(3):267S. PubMed PMID: 1330771. 9: McCabe RT, Newman AH, Skolnick P. AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors. J Pharmacol Exp Ther. 1992 Aug;262(2):734-40. PubMed PMID: 1323661. 10: McEnery MW, Snowman AM, Trifiletti RR, Snyder SH. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3170-4. PubMed PMID: 1373486; PubMed Central PMCID: PMC48827. 11: Riond J, Leplatois P, Laurent P, Le Fur G, Caput D, Loison G, Ferrara P. Expression and pharmacological characterization of the human peripheral-type benzodiazepine receptor in yeast. Eur J Pharmacol. 1991 Dec 12;208(4):307-12. PubMed PMID: 1667758. 12: Cox DA, Ellinor PT, Kirley TL, Matlib MA. Identification of a 17-kDa protein associated with the peripheral-type benzodiazepine receptor in vascular and other smooth muscle types. J Pharmacol Exp Ther. 1991 Aug;258(2):702-9. PubMed PMID: 1650838. 13: Parola AL, Stump DG, Pepperl DJ, Krueger KE, Regan JW, Laird HE 2nd. Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. J Biol Chem. 1991 Jul 25;266(21):14082-7. PubMed PMID: 1649835. 14: Benavides J, Bourdiol F, Dubois A, Scatton B. Regional pattern of increased omega 3 (peripheral type benzodiazepine) binding site densities in the rat brain induced by systemic injection of kainic acid. Neurosci Lett. 1991 Apr 29;125(2):219-22. PubMed PMID: 1652712. 15: Moynagh PN, Bailey CJ, Boyce SJ, Williams DC. Immunological studies on the rat peripheral-type benzodiazepine acceptor. Biochem J. 1991 Apr 15;275 ( Pt 2):419-25. PubMed PMID: 1850987; PubMed Central PMCID: PMC1150070. 16: Bourdiol F, Toulmond S, Serrano A, Benavides J, Scatton B. Increase in omega 3 (peripheral type benzodiazepine) binding sites in the rat cortex and striatum after local injection of interleukin-1, tumour necrosis factor-alpha and lipopolysaccharide. Brain Res. 1991 Mar 15;543(2):194-200. PubMed PMID: 1647831. 17: Parola AL, Laird HE 2nd. The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines. Life Sci. 1991;48(8):757-64. PubMed PMID: 1847230. 18: Newman AH. Irreversible ligands as probes for drug receptors. NIDA Res Monogr. 1991;112:256-83. Review. PubMed PMID: 1661379. 19: Mukhin AG, Zhong PY, Krueger KE. Cofractionation of the 17-kD PK 14105 binding site protein with solubilized peripheral-type benzodiazepine binding sites. Biochem Pharmacol. 1990 Sep 1;40(5):983-9. PubMed PMID: 2167683. 20: Parola AL, MacKenzie NE, Laird HE 2nd. Photochemical derivatization of agarose: synthesis of an affinity agarose using a photoaffinity ligand specific for the peripheral-type benzodiazepine receptor. Anal Biochem. 1990 Aug 15;189(1):107-14. PubMed PMID: 2177588.

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