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MedKoo Cat#: 461639 | Name: Buthiazide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Buthiazide, also known as Butizide, is a 3-isobutyl analog of hydrochlorothiazide.

Chemical Structure

Buthiazide
Buthiazide
CAS#2043-38-1

Theoretical Analysis

MedKoo Cat#: 461639

Name: Buthiazide

CAS#: 2043-38-1

Chemical Formula: C11H16ClN3O4S2

Exact Mass: 353.0271

Molecular Weight: 353.83

Elemental Analysis: C, 37.34; H, 4.56; Cl, 10.02; N, 11.88; O, 18.09; S, 18.12

Price and Availability

Size Price Availability Quantity
100mg USD 350.00 Back order
250mg USD 650.00 Back order
1g USD 1,450.00 Back order
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Related CAS #
No Data
Synonym
Buthiazide; Butizidum; Eunephran; Saltucin; S 3500; S-3500; S3500; Butizide,
IUPAC/Chemical Name
6-chloro-3-isobutyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
InChi Key
HGBFRHCDYZJRAO-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H16ClN3O4S2/c1-6(2)3-11-14-8-4-7(12)9(20(13,16)17)5-10(8)21(18,19)15-11/h4-6,11,14-15H,3H2,1-2H3,(H2,13,16,17)
SMILES Code
O=S(C1=C(Cl)C=C(C2=C1)NC(CC(C)C)NS2(=O)=O)(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Blaschke G, Maibaum J. Enantiomers of benzothiadiazine diuretics by direct chromatographic resolution of the racemic drugs. J Pharm Sci. 1985 Apr;74(4):438-42. doi: 10.1002/jps.2600740414. PMID: 3999006. 2: Lauler DP. European experience with spironolactone and thiazide diuretic as antihypertensive therapy. Am J Cardiol. 1990 Jun 19;65(23):18K-19K. doi: 10.1016/0002-9149(90)91271-7. PMID: 2353666. 3: Deeks ED. Amlodipine/valsartan/hydrochlorothiazide: fixed-dose combination in hypertension. Am J Cardiovasc Drugs. 2009;9(6):411-8. doi: 10.2165/11204350-000000000-00000. PMID: 19929039. 4: Salama A, Mueller-Eckhardt C, Kissel K, Pralle H, Seeger W. Ex vivo antigen preparation for the serological detection of drug-dependent antibodies in immune haemolytic anaemias. Br J Haematol. 1984 Nov;58(3):525-31. doi: 10.1111/j.1365-2141.1984.tb04000.x. PMID: 6208933. 5: Kooter AJ, Smulders YM. Bij hypertensie liever chloortalidon dan hydrochloorthiazide [Chlorthalidone better than hydrochlorothiazide in hypertension]. Ned Tijdschr Geneeskd. 2010;154:A1608. Dutch. PMID: 20456766. 6: Salama A, Mayer B. Diagnostic pitfalls of drug-induced immune hemolytic anemia. Immunohematology. 2014;30(2):80-4. PMID: 25247617. 7: Kalantarian S, Vittinghoff E, Klein L, Scheinman MM. Effect of preload reducing therapy on right ventricular size and function in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2021 Jul;18(7):1186-1191. doi: 10.1016/j.hrthm.2021.03.018. Epub 2021 Mar 17. PMID: 33722762. 8: Kumar V, Shah RP, Singh S. LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products. J Pharm Biomed Anal. 2008 Jul 15;47(3):508-15. doi: 10.1016/j.jpba.2008.01.041. Epub 2008 Feb 7. PMID: 18343073. 9: Koh-Tan HH, Graham D, Hamilton CA, Nicoll G, Fields L, McBride MW, Young B, Dominiczak AF. Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. J Hypertens. 2009 Aug;27(8):1575-84. doi: 10.1097/HJH.0b013e32832cc5a1. PMID: 19531963. 10: De Croo F, Van den Bossche W, De Moerloose P. Simultaneous quantitative determination of butizide, potassium canrenoate and canrenone in tablets by high-performance liquid chromatography. J Chromatogr. 1986 Feb 28;354:367-73. doi: 10.1016/s0021-9673(01)87037-0. PMID: 3700531. 11: Selvaag E, Thune P. Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice. Photodermatol Photoimmunol Photomed. 1997 Feb-Apr;13(1-2):4-8. doi: 10.1111/j.1600-0781.1997.tb00100.x. PMID: 9361121. 12: Engelhardt B, Blalock WA, DonLevy S, Rush M, Hazinski TA. Effect of spironolactone-hydrochlorothiazide on lung function in infants with chronic bronchopulmonary dysplasia. J Pediatr. 1989 Apr;114(4 Pt 1):619-24. doi: 10.1016/s0022-3476(89)80708-5. PMID: 2926575. 13: Nedostup AV, Fedorova VI, Linevich AIu, Pukhal'skaia TG, Toropina GG, Kudrin VS, Klodt PM. [Anxiodepressive and neuromediatory disorders in hypertensive patients. Effects of cypramil therapy]. Ter Arkh. 2005;77(11):55-62. Russian. PMID: 16404864. 14: Fliser D, Schröter M, Neubeck M, Ritz E. Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure. Kidney Int. 1994 Aug;46(2):482-8. doi: 10.1038/ki.1994.298. PMID: 7967362. 15: Bourcier ME, Sherrod A, DiGuardo M, Vinik AI. Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases. J Clin Endocrinol Metab. 2009 Sep;94(9):3157-62. doi: 10.1210/jc.2009-0788. Epub 2009 Jun 30. PMID: 19567519. 16: Brunkhorst R, Wrenger E, Kühn K, Schmidt FW, Koch K. Effekte einer Captopriltherapie auf die Natrium- und Wasserausscheidung bei Patienten mit Leberzirrhose und Aszites [Effect of captopril therapy on sodium and water excretion in patients with liver cirrhosis and ascites]. Klin Wochenschr. 1989 Aug 1;67(15):774-83. German. doi: 10.1007/BF01745350. PMID: 2671477. 17: Suzuki M, Aso T, Sato T, Michimata M, Kazama I, Saiki H, Hatano R, Ejima Y, Miyama N, Sato A, Matsubara M. A case of gain-of-function mutation in calcium- sensing receptor: supplemental hydration is required for renal protection. Clin Nephrol. 2005 Jun;63(6):481-6. doi: 10.5414/cnp63481. PMID: 15960151. 18: SETTEL E. Combined spironolactone-hydrochlorothiazide (Aldactazide) treatment in refractory congestive failure. Curr Ther Res Clin Exp. 1961 Jun;3:243-9. PMID: 13750392. 19: Weishar C. Case study: drug-induced electrolyte changes. Am J Med Technol. 1982 May;48(5):339-41. PMID: 7102716. 20: Lochaya S, Suvachittanont O, Triyanond K. Antihypertensive and hypokalemic effects of isobutyl hydrochlorothiazide alone and in combination with spironolactone. J Med Assoc Thai. 1985 Aug;68(8):399-407. PMID: 3906011.

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