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MedKoo Cat#: 558540 | Name: Maleic hydrazide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Maleic hydrazide is a herbicide that inhibits the sprouting in vegetables and stored root crops, prevention of sucker production in tobacco plants and growth control of grass, and foliage.

Chemical Structure

Maleic hydrazide
Maleic hydrazide
CAS#123-33-1

Theoretical Analysis

MedKoo Cat#: 558540

Name: Maleic hydrazide

CAS#: 123-33-1

Chemical Formula: C4H4N2O2

Exact Mass: 112.0300

Molecular Weight: 112.09

Elemental Analysis: C, 42.86; H, 3.60; N, 24.99; O, 28.55

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 weeks
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Related CAS #
No Data
Synonym
Maleic hydrazide; Hydrazide maleique; Antergon; Antyrost; Burtolin;
IUPAC/Chemical Name
3,6-Pyridazinedione, 1,2-dihydro-
InChi Key
BGRDGMRNKXEXQD-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H4N2O2/c7-3-1-2-4(8)6-5-3/h1-2H,(H,5,7)(H,6,8)
SMILES Code
O=C1C=CC(NN1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 112.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yurdakok B, Baydan E, Okur H, Gurcan IS. Cytotoxic effects of etephon and maleic hydrazide in Vero, Hep2, HepG2 cells. Drug Chem Toxicol. 2014 Oct;37(4):459-65. doi: 10.3109/01480545.2014.884112. Epub 2014 Feb 4. PubMed PMID: 24495230. 2: Wang C, Gu H, Lv M, He R, Zhang J. Surface-enhanced Raman spectroscopic analysis of maleic hydrazide adsorbed on gold surface. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:65-74. doi: 10.1016/j.saa.2013.11.060. Epub 2013 Nov 21. PubMed PMID: 24295778. 3: Pajares A, Bregliani M, Massad W, Natera J, Challier C, Boiero L, Montenegro M, García NA. On the natural fate of maleic hydrazide. Kinetic aspects of the photochemical and microbiological degradation of the herbicide. J Photochem Photobiol B. 2014 Jun 5;135:48-54. doi: 10.1016/j.jphotobiol.2014.04.002. Epub 2014 Apr 18. PubMed PMID: 24796645. 4: De Blauwer V, Demeulemeester K, Demeyere A, Hofmans E. Maleic hydrazide: sprout suppression of potatoes in the field. Commun Agric Appl Biol Sci. 2012;77(3):343-51. PubMed PMID: 23878989. 5: Rizal G, Karki S, Garcia R, Larazo N, Alcasid M, Quick WP. The Use of Maleic Hydrazide for Effective Hybridization of Setaria viridis. PLoS One. 2015 Apr 24;10(4):e0125092. doi: 10.1371/journal.pone.0125092. eCollection 2015. PubMed PMID: 25910193; PubMed Central PMCID: PMC4409208. 6: Wang CR, Zheng DP, Jiang P, Wu JF, Liu YK, Tian W. [Determination of maleic hydrazide residues and its influence on the quality of Atractylodes macrocephala]. Zhong Yao Cai. 2013 Nov;36(11):1743-7. Chinese. PubMed PMID: 24956811. 7: Syberg K, Binderup ML, Cedergreen N, Rank J. Mixture genotoxicity of 2,4-dichlorophenoxyacetic acid, acrylamide, and maleic hydrazide on human Caco-2 cells assessed with comet assay. J Toxicol Environ Health A. 2015;78(6):369-80. doi: 10.1080/15287394.2014.983626. PubMed PMID: 25734764. 8: Mamani Moreno C, Stadler T, da Silva AA, Barbosa LC, de Queiroz ME. Determination of maleic hydrazide residues in garlic bulbs by HPLC. Talanta. 2012 Jan 30;89:369-76. doi: 10.1016/j.talanta.2011.12.045. Epub 2011 Dec 22. PubMed PMID: 22284504. 9: Zhang H, Tang G, Liu N, Bian Z, Hu Q. The Fate of maleic hydrazide on tobacco during smoking. ScientificWorldJournal. 2012;2012:451471. doi: 10.1100/2012/451471. Epub 2012 Oct 23. PubMed PMID: 23193377; PubMed Central PMCID: PMC3485902. 10: Siddiqui S, Meghvansi MK, Khan SS. Glyphosate, alachor and maleic hydrazide have genotoxic effect on Trigonella foenum-graecum L. Bull Environ Contam Toxicol. 2012 May;88(5):659-65. doi: 10.1007/s00128-012-0570-6. Epub 2012 Mar 4. PubMed PMID: 22392005. 11: Van der Heijden CA, Den Tonkelaar EM, Garbis-Berkvens JM, Van Esch GJ. Maleic hydrazide, carcinogenicity study in rats. Toxicology. 1981;19(2):139-50. PubMed PMID: 7268786. 12: Haley TJ. Maleic hydrazide: should the Delaney amendment apply to its use? J Toxicol Environ Health. 1977 May;2(5):1085-94. Review. PubMed PMID: 325222. 13: Renaud JM, Keller I, Vuillaume G. Determination of maleic hydrazide residues in cured tobacco by gas chromatography. J Chromatogr. 1992 Jul 3;604(2):243-6. PubMed PMID: 1517350. 14: Ponnampalam R, Mondy NI, Babish JG. A review of environmental and health risks of maleic hydrazide. Regul Toxicol Pharmacol. 1983 Mar;3(1):38-47. Review. PubMed PMID: 6351180. 15: Kwasniewska J, Mikolajczyk A. Influence of the presence of B chromosomes on DNA damage in Crepis capillaris. PLoS One. 2014 Jan 27;9(1):e87337. doi: 10.1371/journal.pone.0087337. eCollection 2014. PubMed PMID: 24475276; PubMed Central PMCID: PMC3903724. 16: Dhyèvre A, Foltête AS, Aran D, Muller S, Cotelle S. Effects of soil pH on the Vicia-micronucleus genotoxicity assay. Mutat Res Genet Toxicol Environ Mutagen. 2014 Nov 1;774:17-21. doi: 10.1016/j.mrgentox.2014.09.004. Epub 2014 Sep 16. PubMed PMID: 25440906. 17: Mesejo C, Muñoz-Fambuena N, Reig C, Martínez-Fuentes A, Agustí M. Cell division interference in newly fertilized ovules induces stenospermocarpy in cross-pollinated citrus fruit. Plant Sci. 2014 Aug;225:86-94. doi: 10.1016/j.plantsci.2014.05.019. Epub 2014 Jun 2. PubMed PMID: 25017163. 18: Olson LJ, Hinsdill RD, Weltman DJ. The immunomodulatory effects of two plant growth regulators, cycloheximide and maleic hydrazide, in white mice. Drug Chem Toxicol. 1983;6(4):341-61. PubMed PMID: 6617530. 19: Meyer SA, Sheets TJ, Seltmann H. Maleic hydrazide residues in tobacco and their toxicological implications. Rev Environ Contam Toxicol. 1987;98:43-60. Review. PubMed PMID: 3554416. 20: Mertz JL, Lau DY, Borth DM. Liquid chromatographic determination of maleic hydrazide in technical and formulated products: collaborative study. J AOAC Int. 2006 Jul-Aug;89(4):929-36. PubMed PMID: 16915827.