S 12340 | CAS#144754-35-8 | oxygen modification inhibitor

MedKoo Cat#: 461609 | Name: S 12340

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S 12340 is a potent inhibitor of the oxidative modification of low-density lipoprotein.

Chemical Structure

S 12340

CAS#144754-35-8

Theoretical Analysis

MedKoo Cat#: 461609

Name: S 12340

CAS#: 144754-35-8

Chemical Formula: C24H38N2O3S

Exact Mass: 434.2603

Molecular Weight: 434.63

Elemental Analysis: C, 66.32; H, 8.81; N, 6.45; O, 11.04; S, 7.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

S 12340; S-12340; S12340;

IUPAC/Chemical Name

8-(3-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)propyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

InChi Key

AQYBPUABOQSUHO-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H38N2O3S/c1-22(2,3)18-14-17(15-19(20(18)27)23(4,5)6)30-13-7-10-26-11-8-24(9-12-26)16-25-21(28)29-24/h14-15,27H,7-13,16H2,1-6H3,(H,25,28)

SMILES Code

O=C1OC2(CCN(CCCSC3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)CC2)CN1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Breugnot C, Privat S, Guillonneau C, Regnier G, Bouzom F, Vilaine JP, Lenaers A. S 12340: a potent inhibitor of the oxidative modification of low-density lipoprotein in vitro and ex vivo in WHHL rabbits. J Pharmacol Exp Ther. 1994 May;269(2):515-20. PubMed PMID: 8182520. 2: Iliou JP, Thollon C, Robin F, Cambarrat C, Guillonneau C, Régnier G, Lenaers A, Vilaine JP. Protective effect of S12340 on cardiac cells exposed to oxidative stress. Eur J Pharmacol. 1993 Oct 1;248(3):263-72. PubMed PMID: 8293791.