MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 461607 | Name: Cinmetacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinmetacin is a non-steroidal anti-inflammatory drug.

Chemical Structure

Cinmetacin
Cinmetacin
CAS#20168-99-4

Theoretical Analysis

MedKoo Cat#: 461607

Name: Cinmetacin

CAS#: 20168-99-4

Chemical Formula: C21H20NO4

Exact Mass: 350.1392

Molecular Weight: 350.39

Elemental Analysis: C, 71.98; H, 5.75; N, 4.00; O, 18.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Cinmetacin; Cindomet; Cinmetacinum; Indolacin; S 1290; S-1290; S1290;
IUPAC/Chemical Name
(E)-2-hydroxy-1-(5-methoxy-2-methyl-1H-indol-3-yl)-5-phenyl-2l5-pent-4-ene-2,3-dione
InChi Key
TXSPTCJNIDCTMA-DHZHZOJOSA-N
InChi Code
InChI=1S/C21H20NO4/c1-14-18(17-12-16(26-2)9-10-19(17)22-14)13-21(24,25)20(23)11-8-15-6-4-3-5-7-15/h3-12,22H,13H2,1-2H3,(H,24,25)/b11-8+
SMILES Code
O=C(O)(C(/C=C/C1=CC=CC=C1)=O)CC2=C(C)NC3=C2C=C(OC)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Montero MT, Pouplana R, Valls O, García S. On the binding of cinmetacin and indomethacin to human serum albumin. J Pharm Pharmacol. 1986 Dec;38(12):925-7. PubMed PMID: 2880970. 2: Danesi R, Ducci M, Acerbi D, Del Tacca M. Plasma pharmacokinetics of cinmetacin following oral administration in healthy volunteers. Arzneimittelforschung. 1988 Jan;38(1):129-31. PubMed PMID: 3259136. 3: Myung SW, Kim MS, Yoon CN, Park JS, Ahn WS. Gas chromatographic-electron-impact chemical ionization mass spectrometric identification of cinmetacin and its metabolites in human urine. J Chromatogr B Biomed Appl. 1994 Oct 3;660(1):75-84. PubMed PMID: 7858726. 4: Krasowska H. Solubilization of indomethacin and cinmetacin by non-ionic surfactants of the polyoxyethylene type. Farmaco Prat. 1976 Sep;31(9):463-72. PubMed PMID: 1010020. 5: Viara M. [Brief note on the use of cinmetacin in the treatment of rheumatic diseases]. Clin Ter. 1977 Jun 30;81(6):555-66. Italian. PubMed PMID: 301808. 6: Komatsu T, Saito C, Awata H, Sakai Y, Inukai T. Anti-inflammatory activities of 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid (cinmetacin). Arzneimittelforschung. 1973 Dec;23(12):1690-6. PubMed PMID: 4544613. 7: Lucietti MV, Banchieri G. [Clinical study of the efficacy of and tolerance for a new nonsteroidal anti-inflammatory agent, cinmetacin]. G Clin Med. 1980 Jul;61(7):545-52. Italian. PubMed PMID: 7004981.