S 11568 | CAS#132636-01-2 | Ca channel antagonist

MedKoo Cat#: 461606 | Name: S 11568

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S 11568 is a dihydropyridine calcium channel antagonist.

Chemical Structure

S 11568

CAS#132636-01-2

Theoretical Analysis

MedKoo Cat#: 461606

Name: S 11568

CAS#: 132636-01-2

Chemical Formula: C22H29Cl3N2O6

Exact Mass: 522.1091

Molecular Weight: 523.83

Elemental Analysis: C, 50.44; H, 5.58; Cl, 20.30; N, 5.35; O, 18.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

S 11568; S-11568; S11568; S 12968; S-12968; S12968;

IUPAC/Chemical Name

3-ethyl 5-methyl 2-((2-(2-aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

InChi Key

CHEDLCOJOZRZRL-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H28Cl2N2O6.ClH/c1-4-32-22(28)19-16(12-31-11-10-30-9-8-25)26-13(2)17(21(27)29-3)18(19)14-6-5-7-15(23)20(14)24;/h5-7,18,26H,4,8-12,25H2,1-3H3;1H

SMILES Code

O=C(C1=C(COCCOCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC(Cl)=C2Cl)OCC.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 523.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Valette H, Dollé F, Guenther I, Hinnen F, Fuseau C, Coulon C, Péglion JL, Crouzel C. Myocardial kinetics of the (11)C-labeled enantiomers of the Ca(2+) channel inhibitor S11568: an in vivo study. J Nucl Med. 2001 Jun;42(6):932-7. PubMed PMID: 11390559. 2: Dollé F, Valette H, Hinnen F, Fuseau C, Péglion JL, Crouzel C. Synthesis and characterization of a 11C-labelled derivative of S12968: an attempt to image in vivo brain calcium channels. Nucl Med Biol. 1998 May;25(4):339-42. PubMed PMID: 9639294. 3: Dollé F, Hinnen F, Valette H, Fuseau C, Duval R, Péglion JL, Crouzel C. Synthesis of two optically active calcium channel antagonists labelled with carbon-11 for in vivo cardiac PET imaging. Bioorg Med Chem. 1997 Apr;5(4):749-64. PubMed PMID: 9158874. 4: Valette H, Crouzel C, Syrota A, Fuseau C, Bourachot ML. Canine myocardial dihydropyridine binding sites: a positron emission tomographic study with the calcium channel inhibitor 11C-S11568. Life Sci. 1994;55(19):1471-7. PubMed PMID: 7968214. 5: Morain P, Peglion JL, Giesen-Crouse E. Ca2+ channel inhibition in a rat osteoblast-like cell line, UMR 106, by a new dihydropyridine derivative, S11568. Eur J Pharmacol. 1992 Sep 10;220(1):11-7. PubMed PMID: 1385178. 6: Makki T, Lartaud I, Bray-des Boscs L, Capdeville-Atkinson C, Chillon JM, Hoffman M, Nicolas JP, Atkinson J. Haemodynamic effects of a new dihydropyridine calcium entry blocker, S-12968-(-), in a rat model of cardiovascular calcium overload. Br J Pharmacol. 1992 May;106(1):79-84. PubMed PMID: 1324069; PubMed Central PMCID: PMC1907437. 7: Vilaine JP, Biondi ML, Villeneuve N, Feletou M, Peglion JL, Vanhoutte PM. The calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries. Eur J Pharmacol. 1991 May 2;197(1):41-8. PubMed PMID: 1654260. 8: Randle JC, Péglion JL, Renaud JF. Inhibition of L-type but not T-type calcium channel current by a new dihydropyridine derivative, S11568. J Cardiovasc Pharmacol. 1991 Feb;17(2):348-50. PubMed PMID: 1709243. 9: Randle JC, Lombet A, Nagel N, Abraham C, Aptel H, Peglion JL, Renaud JF. Ca2+ channel inhibition by a new dihydropyridine derivative, S11568, and its enantiomers S12967 and S12968. Eur J Pharmacol. 1990 Nov 6;190(1-2):85-96. PubMed PMID: 1706275.