MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 563591 | Name: INH6
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

INH6 is a cell-permeable Hec1/Nek2 Mitotic Pathway Inhibitor.

Chemical Structure

INH6
INH6
CAS#1001753-24-7

Theoretical Analysis

MedKoo Cat#: 563591

Name: INH6

CAS#: 1001753-24-7

Chemical Formula: C19H18N2OS

Exact Mass: 322.1140

Molecular Weight: 322.43

Elemental Analysis: C, 70.78; H, 5.63; N, 8.69; O, 4.96; S, 9.94

Price and Availability

Size Price Availability Quantity
5mg USD 150.00 2 Weeks
10mg USD 250.00 2 Weeks
50mg USD 600.00 2 Weeks
100mg USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
INH6; INH-6; INH 6; Hec1/Nek2 Mitotic Pathway Inhibitor II;
IUPAC/Chemical Name
N-[4-(2,4,6-Trimethylphenyl)-1,3-thiazol-2-yl]benzamide
InChi Key
WCZLNJTXHZPHLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)
SMILES Code
O=C(NC1=NC(C2=C(C)C=C(C)C=C2C)=CS1)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC50 of 2.4 μM.
In vitro activity:
In MDA-MB-231 cells, Nek2 inhibition by INH6 reduced the β-catenin and Slug mRNA levels compared with control (Fig. 6a). Reference: Sci Rep. 2021 Apr 27;11(1):9016. https://pubmed.ncbi.nlm.nih.gov/33907253/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 42.0 130.26
Ethanol 6.0 18.61
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 322.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Rivera-Rivera Y, Marina M, Jusino S, Lee M, Velázquez JV, Chardón-Colón C, Vargas G, Padmanabhan J, Chellappan SP, Saavedra HI. The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Sci Rep. 2021 Apr 27;11(1):9016. doi: 10.1038/s41598-021-88512-0. PMID: 33907253; PMCID: PMC8079711.
In vitro protocol:
1. Rivera-Rivera Y, Marina M, Jusino S, Lee M, Velázquez JV, Chardón-Colón C, Vargas G, Padmanabhan J, Chellappan SP, Saavedra HI. The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Sci Rep. 2021 Apr 27;11(1):9016. doi: 10.1038/s41598-021-88512-0. PMID: 33907253; PMCID: PMC8079711.
In vivo protocol:
TBD
1: Pease C, Hutton B, Yazdi F, Wolfe D, Hamel C, Quach P, Skidmore B, Moher D, Alvarez GG. Efficacy and completion rates of rifapentine and isoniazid (3HP) compared to other treatment regimens for latent tuberculosis infection: a systematic review with network meta-analyses. BMC Infect Dis. 2017 Apr 11;17(1):265. doi: 10.1186/s12879-017-2377-x. Review. PubMed PMID: 28399802; PubMed Central PMCID: PMC5387294. 2: Niu Y, Song Y, Hou H, Zhu Y. Synthesis, structure, and large optical limiting effect of the first coordination polymeric cluster based on an {I@[AgI(inh)]6} hexagram block. Inorg Chem. 2005 Apr 4;44(7):2553-9. PubMed PMID: 15792494.

View History

Lavanducyanin

Lavanducyanin

GRP-156784

GRP-156784

Ingenol 3,20-dibenzoate

Ingenol 3,20-dibenzoate

Bcr-Abl-IN-Y9

Bcr-Abl-IN-Y9

BDF5

BDF5

Glucurolactone

Glucurolactone