Related CAS #
305-97-5 (free)
Synonym
Anthiomaline nonahydrate; Antimony lithium thiomalate nonahydrate;
IUPAC/Chemical Name
lithium (2S,2'S)-2,2'-(((((R)-1,2-dicarboxylatoethyl)thio)stibanediyl)bis(sulfanediyl))disuccinate nonahydrate
InChi Key
FYBDVMKPGKKXEY-ZJZOBTDDSA-E
InChi Code
InChI=1S/3C4H6O4S.6Li.9H2O.Sb/c3*5-3(6)1-2(9)4(7)8;;;;;;;;;;;;;;;;/h3*2,9H,1H2,(H,5,6)(H,7,8);;;;;;;9*1H2;/q;;;6*+1;;;;;;;;;;+3/p-9/t3*2-;;;;;;;;;;;;;;;;/m100................/s1
SMILES Code
O=C([O-])C[C@@H](C([O-])=O)S[Sb](S[C@@H](C([O-])=O)CC([O-])=O)S[C@H](C([O-])=O)CC([O-])=O.[Li+].[Li+].[Li+].[Li+].[Li+].[Li+].O.O.O.O.O.O.O.O.O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
766.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: HALAWANI A, DAWOOD MM. Evaluation of the treatment of bilharziasis with fouadin, stibophen and anthiomaline with special reference to the apparent cure-rates and relapse-rates. J Egypt Med Assoc. 1953;36(5-6):339-56. PubMed PMID: 13084832.
2: RAO BS, KHAN AH. Anthiomaline in the treatment of infectious granuloma of dogs. Indian Vet J. 1948 Mar;24(5):345. PubMed PMID: 18863369.
3: ROLLIER R, ROLLIER M, GARZON J. [Lupus erythematosus aggravated by anthiomaline]. Bull Soc Fr Dermatol Syphiligr. 1962 Apr-May;69:414-8. French. PubMed PMID: 13982539.
4: RITCHKEN J, SANDERS E. Urinary bilharziasis: the results of treatment with anthiomaline administered intravenously in sixty-two cases. Cent Afr J Med. 1956 Jul;2(7):249-53. PubMed PMID: 13356311.
5: BROWN HW. Treatment of filariasis with anthiomaline (lithium antimony thiomalate). Ann N Y Acad Sci. 1948 May 25;50(21-26):51-72. PubMed PMID: 18860239.
6: TRENT SC. Anthiomaline and neostibosan in the treatment of filariasis, (Dirofilaria immitis.). PR J Public Health Trop Med. 1948 Mar;23(3):311-60. PubMed PMID: 18880270.
7: HERNANDEZ MORALES F, SANTIAGO STEVENSON D. An evaluation of the therapeutic effectiveness of fuadin and anthiomaline in the treatment of Manson's schistosomiasis. PR J Public Health Trop Med. 1949 Dec;25(2):256-60 Also Spanish transl, 261-6. PubMed PMID: 15399329.
8: SUAREZ RM, SANTIAGO-STEVENSON D, HERNANDEZ-MORALES F. Electrocardiographic changes during anthiomaline treatment of schistosomiasis. Am Heart J. 1948 Dec;36(6):923-33. PubMed PMID: 18893576.
9: ROLLIER R, ROLLIER M, GARZON J. [Lupus erythematosus aggravated by anthiomaline]. Lyon Med. 1962 Sep 30;94:531-5. French. PubMed PMID: 13982540.
10: Ercoli N, Minelli EB, Olivo N. Antitrypanosomal activity of trivalent antimonials in vitro and its significance. Chemotherapy. 1980;26(4):254-62. PubMed PMID: 6248299.
11: MANN PH. Determination of the antheimintic action of anthiomaline and piperazine HCl following intravenous injections into dogs. Cornell Vet. 1959 Apr;49(2):194-7. PubMed PMID: 13639581.
12: FLOCH H. [The activity of intramuscular glucantime and of intravenous anthiomaline in the treatment of sylvan American leishmaniasis]. Publ Inst Pasteur Guyane Fr Inini. 1955 Feb;16(353):1-8. French. PubMed PMID: 13249658.
13: RODRIGUEZ-MOLINA R, ACEVEDO CE, TORRES JM, LOPEZ-SANABRIA U, RAMIREZ-RODRIGUEZ E. Treatment of schistosomiasis mansoni with antimony lithium thiomalate (Anthiomaline); final report. Am J Trop Med Hyg. 1950 Nov;30(6):881-6. PubMed PMID: 14790178.
14: TRENT SC. Anthiomaline in the treatment of schistosomiasis mansoni. J Am Med Womens Assoc. 1962 Feb;17:123-8. PubMed PMID: 13922416.
15: HERNANDEZ MORALES F, SUAREZ RM, et al. Treatment of schistosomiasis mansoni with antimony lithium thiomalate (anthiomaline). PR J Public Health Trop Med. 1946 Jun;21:336-43, Spanish transl 344-9. PubMed PMID: 20996524.
16: NEECH SE. Anthiomaline in filariasis. J Christ Med Assoc India. 1945 Sep;20:150-2. PubMed PMID: 21003764.
17: GOLDBERG LC. Treatment of granuloma inguinale with anthiomaline; report of case with extragenital lesion. Am J Syph Gonorrhea Vener Dis. 1945 Nov;29:608-10. PubMed PMID: 21005454.
18: Jennings FW. Chemotherapy of trypanosomiasis: the potentiation of antimonial compounds by difluoromethylornithine (DFMO). Trop Med Parasitol. 1991 Jun;42(2):135-8. PubMed PMID: 1654590.
19: AYYAR SR. Treatment of filariasis by lithium antimony thiomalate. Ind Med Gaz. 1949 Mar;84(3):100-2. PubMed PMID: 18131731; PubMed Central PMCID: PMC5196139.
20: REY M, CAMAIN R, HOCQUET P, BOURGEADE A. [MODIFICATIONS OF HEPATIC LESIONS OF INTESTINAL BILHARZIOSIS AFTER TREATMENT BY ASSOCIATED AMPHOTALID AND ANTHIOLIMINE]. Bull Soc Med Afr Noire Lang Fr. 1964;9:204-8. French. PubMed PMID: 14279592.
