Wogonin | CAS#632-85-9 | anti-tumor agent

MedKoo Cat#: 584502 | Name: Wogonin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Wogonin is a flavonoid compound derived from Scutellaria baicalensis (Chinese skullcap) with diverse pharmacological properties. It exhibits anti-inflammatory, antioxidant, and anticancer activities by modulating key signaling pathways such as NF-κB, MAPK, and apoptosis-related proteins. Wogonin has been studied for its potential neuroprotective effects, as well as its ability to enhance cancer cell apoptosis while sparing normal cells.

Chemical Structure

Wogonin

CAS#632-85-9

Theoretical Analysis

MedKoo Cat#: 584502

Name: Wogonin

CAS#: 632-85-9

Chemical Formula: C16H12O5

Exact Mass: 284.0685

Molecular Weight: 284.27

Elemental Analysis: C, 67.60; H, 4.26; O, 28.14

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 375.00	2 weeks
250mg	USD 1,050.00	2 weeks

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Related CAS #

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Synonym

Wogonin; Vogonin

IUPAC/Chemical Name

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

InChi Key

XLTFNNCXVBYBSX-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3

SMILES Code

O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 284.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hou YJ, Xiao KN, Bi JY, Zhang XJ, Li XR, Wang YQ, Su M, Sun XR, Zhang H, Wang BY, Wang LJ, Liu SX. [Pharmacokinetics study of Dayuanyin in normal and febrile rats]. Zhongguo Zhong Yao Za Zhi. 2025 Jan;50(2):527-533. Chinese. doi: 10.19540/j.cnki.cjcmm.20241010.201. PMID: 39929633. 2: Yang B, Wang C, Chen X, Zhai H, Wu Y, Cui M, Wu J, Li W, Hua B. In silico and animal studies on the anti-cancer mechanisms of Shaoyao Decoction against colitis-associated colorectal cancer. J Ethnopharmacol. 2025 Feb 8:119444. doi: 10.1016/j.jep.2025.119444. Epub ahead of print. PMID: 39929402. 3: Amin H, S Althagafy H, S Abd El-Maksoud M, M Ibrahim I, H M Hassanein E. Flavonoids in combating renal fibrosis: Targeting NF-κB signal and in silico support. Chem Biodivers. 2025 Feb 9:e202403022. doi: 10.1002/cbdv.202403022. Epub ahead of print. PMID: 39924970. 4: Xu X, Qian Y, Zhu S, Tian H, Zhai P, Zhu S, Wang J, Xie L, Qin S. Wogonin inhibits radiation-induced DNA damage repair in hepatocellular carcinoma cells by upregulating p21. Korean J Physiol Pharmacol. 2025 Feb 6. doi: 10.4196/kjpp.24.213. Epub ahead of print. PMID: 39910708. 5: Wang Y, Chen X, Zhou F, Pan M, Huang Y, Tsunoda M, Zhang Y, Yang H, Li LS, Song Y. Bidirectional transport studies of flavonoids from Alpiniae oxyphyllae fructus by in vitro inflammatory blood-brain barrier model combined with UHPLC- MS/MS analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Jan 13;1253:124471. doi: 10.1016/j.jchromb.2025.124471. Epub ahead of print. PMID: 39889610. 6: Li XM, Zhu JW, Li KW, Han XY, Ruan JR, Chu HR. Exploring the Mechanism of Shi-San-Wei-He-Zhong-Wan in the Treatment of Functional Dyspepsia Based on Network Pharmacology and Experimental Validation. Comb Chem High Throughput Screen. 2025 Jan 23. doi: 10.2174/0113862073358956241203101815. Epub ahead of print. PMID: 39851100. 7: Shao Q, Zhao Y, Shi Y, Cheng F, Zhang Z, Liu Y, Li C, Ren Z, Bai H, Cheng H, Maddela R, Tian J, Wang X. Chemical characterization of Siraitia grosvenorii granules and their efficacy and mechanism of action on PM2.5-induced acute lung injury. Ecotoxicol Environ Saf. 2025 Jan 16;290:117702. doi: 10.1016/j.ecoenv.2025.117702. Epub ahead of print. PMID: 39823669. 8: Fu Q, Yu Q, Luo H, Liu Z, Ma X, Wang H, Cheng Z. Protective effects of wogonin in the treatment of central nervous system and degenerative diseases. Brain Res Bull. 2025 Feb;221:111202. doi: 10.1016/j.brainresbull.2025.111202. Epub 2025 Jan 13. PMID: 39814324. 9: Grzelka K, Matkowski A, Chodaczek G, Jaśpińska J, Pawlikowska-Bartosz A, Słupski W, Lechniak D, Szumacher-Strabel M, Olorunlowu S, Szulc K, Cieślak A, Ślusarczyk S. Pulsed Electric Field (PEF) Treatment Results in Growth Promotion, Main Flavonoids Extraction, and Phytochemical Profile Modulation of Scutellaria baicalensis Georgi Roots. Int J Mol Sci. 2024 Dec 26;26(1):100. doi: 10.3390/ijms26010100. PMID: 39795960; PMCID: PMC11719946. 10: Ślusarczyk S, Grzelka K, Jaśpińska J, Pawlikowska-Bartosz A, Pecio Ł, Stafiniak M, Rahimmalek M, Słupski W, Cieślak A, Matkowski A. Changes in Growth and Metabolic Profile of Scutellaria baicalensis Georgi in Response to Sodium Chloride. Biology (Basel). 2024 Dec 17;13(12):1058. doi: 10.3390/biology13121058. PMID: 39765725; PMCID: PMC11673518. 11: Bian B, Ge C, Wu F, Fan Y, Kong J, Li K, Bian H, Miao Q. Wogonin Attenuates Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress Injury via the MAPK Signaling Pathway. Biol Pharm Bull. 2024;47(12):2165-2172. doi: 10.1248/bpb.b24-00534. PMID: 39756931. 12: Zhang XH, Liu J, Ding X, Chen XL. Chinese herbal medicines and its active ingredient wogonin can improve immune inflammation in psoriatic arthritis. Int Immunopharmacol. 2025 Feb 6;147:113984. doi: 10.1016/j.intimp.2024.113984. Epub 2025 Jan 2. PMID: 39752753. 13: Liu Y, Zhang Z, Li X, Hu Q, Jiang Z, Lv J, Xue J, Wang D, Cao J, Li L, Ou X, Zhu L, Liu Z, Su T. Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions. Pharmacol Res. 2025 Feb;212:107570. doi: 10.1016/j.phrs.2024.107570. Epub 2024 Dec 31. PMID: 39746499. 14: Ren L, Ruan X, Dong H, Cheng Y, Shon K, Chang C, Gu R, Sun Z. The bitter flavor of Banxia Xiexin decoction activates TAS2R38 to ameliorate low-grade inflammation in the duodenum of mice with functional dyspepsia. J Ethnopharmacol. 2025 Feb 11;341:119309. doi: 10.1016/j.jep.2024.119309. Epub 2024 Dec 31. PMID: 39746410. 15: Liu A, Zhong M, Han Z, Yan Y, Zhang D, Wang X, Wang M, Zou Y, Zhang J. Characterization of Active Compounds in Sanhuang Shu'ai Decoction for the Management of Ulcerative Colitis: A UHPLC-MS Study. Rapid Commun Mass Spectrom. 2025 Mar 30;39(6):e9976. doi: 10.1002/rcm.9976. PMID: 39740112. 16: Dong P, Lu Y, Bai J, Zhao C, Li Z, Cao Y, Li Y. The influence of rhizosphere microbial diversity on the accumulation of active compounds in farmed Scutellaria baicalensis. PeerJ. 2024 Dec 24;12:e18749. doi: 10.7717/peerj.18749. PMID: 39735561; PMCID: PMC11674151. 17: Wan C, Sun S, Han Y, Du Y, Li X, Zhang L, Yang Y, Hao J, Wu Y. Integrating lipid metabolomics, serum medicinal chemistry, network pharmacology and experimental validation to explore the mechanism of Sanmiao wan in the treatment of rheumatoid arthritis. J Ethnopharmacol. 2025 Jan 31;340:119295. doi: 10.1016/j.jep.2024.119295. Epub 2024 Dec 27. PMID: 39733801. 18: Song Y, Zhao H, Yu R, Zhang Y, Zou Y, Liu X, Sun S. Wogonin suppresses proliferation, invasion and migration in gastric cancer cells via targeting the JAK-STAT3 pathway. Sci Rep. 2024 Dec 28;14(1):30803. doi: 10.1038/s41598-024-81196-2. PMID: 39730467; PMCID: PMC11681093. 19: Yang Y, Liu Y, Cheng Y, He H, Liang A, Pan Z, Liu Y, Chen Z. Multi-omics and experimental analysis unveil the key components in Scutellaria baicalensis Georgi to alleviate hepatic fibrosis via regulating cPLA2-mediated arachidonic acid metabolism. J Transl Med. 2024 Dec 23;22(1):1138. doi: 10.1186/s12967-024-05955-5. PMID: 39716274; PMCID: PMC11665060. 20: Li J, Zhuang Y, Fan G, Wang S, Yan E, Guo J, Zhang C, Jiang S. Impact of baicalin and components of Scutellaria baicalensis on renal fibrosis of diabetic kidney disease. Front Pharmacol. 2024 Dec 6;15:1480626. doi: 10.3389/fphar.2024.1480626. PMID: 39712489; PMCID: PMC11658968.