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MedKoo Cat#: 598998 | Name: Lissoclinamide 4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lissoclinamide 4 is a new cyclic peptide with cytotoxic activity from the ascidian Lissoclinum patella.

Chemical Structure

Lissoclinamide 4
CAS#120853-16-9

Theoretical Analysis

MedKoo Cat#: 598998

Name: Lissoclinamide 4

CAS#: 120853-16-9

Chemical Formula: C38H43N7O5S2

Exact Mass: 741.2767

Molecular Weight: 741.92

Elemental Analysis: C, 61.52; H, 5.84; N, 13.22; O, 10.78; S, 8.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Lissoclinamide 4;
IUPAC/Chemical Name
(12S,22Z,24S,25R,62Z,64R,102Z,5S,9R,13S)-9,13-dibenzyl-5-isopropyl-25-methyl-24,25,64,65-tetrahydro-4,8,12-triaza-2(2,4)-oxazola-6,10(2,4)-dithiazola-1(2,1)-pyrrolidinacyclotetradecaphane-3,7,11,14-tetraone
InChi Key
HKYACNDBJBTRBK-OZEYYBSUSA-N
InChi Code
InChI=1S/C38H43N7O5S2/c1-21(2)30-37-42-28(20-52-37)32(46)39-25(17-23-11-6-4-7-12-23)36-41-27(19-51-36)33(47)40-26(18-24-13-8-5-9-14-24)38(49)45-16-10-15-29(45)35-44-31(22(3)50-35)34(48)43-30/h4-9,11-14,19,21-22,25-26,28-31H,10,15-18,20H2,1-3H3,(H,39,46)(H,40,47)(H,43,48)/t22-,25-,26+,28+,29+,30+,31+/m1/s1
SMILES Code
O=C1N[C@H](Cc2ccccc2)c3nc(C(N[C@@H](Cc4ccccc4)C(N(CCC5)[C@@H]5C6=N[C@@H]([C@@H](C)O6)C(N[C@@H](C(C)C)C7=N[C@H]1CS7)=O)=O)=O)cs3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 741.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Degnan BM, Hawkins CJ, Lavin MF, McCaffrey EJ, Parry DL, van den Brenk AL, Watters DJ. New cyclic peptides with cytotoxic activity from the ascidian Lissoclinum patella. J Med Chem. 1989 Jun;32(6):1349-54. PubMed PMID: 2724305. 2: Hawkins CJ, Lavin MF, Marshall KA, van den Brenk AL, Watters DJ. Structure-activity relationships of the lissoclinamides: cytotoxic cyclic peptides from the ascidian Lissoclinum patella. J Med Chem. 1990 Jun;33(6):1634-8. PubMed PMID: 2342056. 3: Rashid MA, Gustafson KR, Cardellina JH 2nd, Boyd MR. Patellamide F, A new cytotoxic cyclic peptide from the colonial ascidian Lissoclinum patella. J Nat Prod. 1995 Apr;58(4):594-7. PubMed PMID: 7623037.