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MedKoo Cat#: 563567 | Name: Epigenetic Multiple Ligand
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.

Chemical Structure

Epigenetic Multiple Ligand
Epigenetic Multiple Ligand
CAS#1020399-52-3

Theoretical Analysis

MedKoo Cat#: 563567

Name: Epigenetic Multiple Ligand

CAS#: 1020399-52-3

Chemical Formula: C19H12Br4O4

Exact Mass: 619.7469

Molecular Weight: 623.91

Elemental Analysis: C, 36.58; H, 1.94; Br, 51.23; O, 10.26

Price and Availability

Size Price Availability Quantity
250mg USD 1,450.00 2 Weeks
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Related CAS #
No Data
Synonym
Epigenetic Multiple Ligand; epi-ML; epi ML; epiML; PRMT Inhibitor IV
IUPAC/Chemical Name
3,5-Bis-(3,5-dibromo-4-hydroxy-benzylidene)-tetrahydro-pyran-4-one
InChi Key
JEDNMNJCJIIYJR-NJDSBKIZSA-N
InChi Code
InChI=1S/C19H12Br4O4/c20-13-3-9(4-14(21)18(13)25)1-11-7-27-8-12(17(11)24)2-10-5-15(22)19(26)16(23)6-10/h1-6,25-26H,7-8H2/b11-1+,12-2+
SMILES Code
O=C1/C(COC/C1=C\C2=CC(Br)=C(O)C(Br)=C2)=C/C3=CC(Br)=C(O)C(Br)=C3
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 623.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang Y, Wang H, Yao H, Li C, Fang JY, Xu J. Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion. Front Pharmacol. 2018 May 22;9:536. doi: 10.3389/fphar.2018.00536. eCollection 2018. Review. PubMed PMID: 29910728; PubMed Central PMCID: PMC5992436. 2: Patel P, Patel VK, Singh A, Jawaid T, Kamal M, Rajak H. Identification of Hydroxamic Acid Based Selective HDAC1 Inhibitors: Computer Aided Drug Design Studies. Curr Comput Aided Drug Des. 2018 May 1. doi: 10.2174/1573409914666180502113135. [Epub ahead of print] PubMed PMID: 29732991. 3: Triff K, McLean MW, Callaway E, Goldsby J, Ivanov I, Chapkin RS. Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model. Int J Cancer. 2018 Apr 16. doi: 10.1002/ijc.31525. [Epub ahead of print] PubMed PMID: 29659013. 4: Sanli I, Lalevée S, Cammisa M, Perrin A, Rage F, Llères D, Riccio A, Bertrand E, Feil R. Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis. Cell Rep. 2018 Apr 10;23(2):337-348. doi: 10.1016/j.celrep.2018.03.044. PubMed PMID: 29641995. 5: Bowkett D, Talon R, Tallant C, Schofield C, von Delft F, Knapp S, Bruton G, Brennan PE. Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces. ChemMedChem. 2018 May 23;13(10):1051-1057. doi: 10.1002/cmdc.201800030. Epub 2018 Apr 17. PubMed PMID: 29578648; PubMed Central PMCID: PMC6001751. 6: Rosenzweig SA. Acquired Resistance to Drugs Targeting Tyrosine Kinases. Adv Cancer Res. 2018;138:71-98. doi: 10.1016/bs.acr.2018.02.003. Epub 2018 Mar 2. PubMed PMID: 29551130; PubMed Central PMCID: PMC5985159. 7: Yao L, Ohlson S, Dymock BW. Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90). Bioorg Med Chem Lett. 2018 May 1;28(8):1357-1362. doi: 10.1016/j.bmcl.2018.03.009. Epub 2018 Mar 3. PubMed PMID: 29545103. 8: Wang H, Cao G, Wang G, Hao H. Regulation of Mammalian UDP-Glucuronosyltransferases. Curr Drug Metab. 2018;19(6):490-501. doi: 10.2174/1389200219666180307122945. PubMed PMID: 29521218. 9: Jayaraman A, Sharma M, Prabhakar B, Holterman M, Jayaraman S. Amelioration of progressive autoimmune encephalomyelitis by epigenetic regulation involves selective repression of mature neutrophils during the preclinical phase. Exp Neurol. 2018 Jun;304:14-20. doi: 10.1016/j.expneurol.2018.02.008. Epub 2018 Feb 14. PubMed PMID: 29453977. 10: Nocturne G, Mariette X. B cells in the pathogenesis of primary Sjögren syndrome. Nat Rev Rheumatol. 2018 Mar;14(3):133-145. doi: 10.1038/nrrheum.2018.1. Epub 2018 Feb 8. Review. PubMed PMID: 29416129. 11: Albertini S, Lo Cigno I, Calati F, De Andrea M, Borgogna C, Dell'Oste V, Landolfo S, Gariglio M. HPV18 Persistence Impairs Basal and DNA Ligand-Mediated IFN-β and IFN-λ(1) Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling. J Immunol. 2018 Mar 15;200(6):2076-2089. doi: 10.4049/jimmunol.1701536. Epub 2018 Jan 31. PubMed PMID: 29386255. 12: Venet F, Monneret G. Advances in the understanding and treatment of sepsis-induced immunosuppression. Nat Rev Nephrol. 2018 Feb;14(2):121-137. doi: 10.1038/nrneph.2017.165. Epub 2017 Dec 11. Review. PubMed PMID: 29225343. 13: Helpman L, Zhu X, Suarez-Jimenez B, Lazarov A, Monk C, Neria Y. Sex Differences in Trauma-Related Psychopathology: a Critical Review of Neuroimaging Literature (2014-2017). Curr Psychiatry Rep. 2017 Nov 8;19(12):104. doi: 10.1007/s11920-017-0854-y. Review. PubMed PMID: 29116470; PubMed Central PMCID: PMC5737777. 14: Kanjee U, Grüring C, Chaand M, Lin KM, Egan E, Manzo J, Jones PL, Yu T, Barker R Jr, Weekes MP, Duraisingh MT. CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9356-E9365. doi: 10.1073/pnas.1711310114. Epub 2017 Oct 19. PubMed PMID: 29078358; PubMed Central PMCID: PMC5676921. 15: De Kumar B, Parker HJ, Paulson A, Parrish ME, Zeitlinger J, Krumlauf R. Hoxa1 targets signaling pathways during neural differentiation of ES cells and mouse embryogenesis. Dev Biol. 2017 Dec 1;432(1):151-164. doi: 10.1016/j.ydbio.2017.09.033. Epub 2017 Oct 2. PubMed PMID: 28982536. 16: Herranz-López M, Olivares-Vicente M, Encinar JA, Barrajón-Catalán E, Segura-Carretero A, Joven J, Micol V. Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity. Nutrients. 2017 Aug 20;9(8). pii: E907. doi: 10.3390/nu9080907. Review. PubMed PMID: 28825642; PubMed Central PMCID: PMC5579700. 17: Thorsell A, Mathé AA. Neuropeptide Y in Alcohol Addiction and Affective Disorders. Front Endocrinol (Lausanne). 2017 Jul 31;8:178. doi: 10.3389/fendo.2017.00178. eCollection 2017. Review. PubMed PMID: 28824541; PubMed Central PMCID: PMC5534438. 18: Husain A, Jeffries MA. Epigenetics and Bone Remodeling. Curr Osteoporos Rep. 2017 Oct;15(5):450-458. doi: 10.1007/s11914-017-0391-y. Review. PubMed PMID: 28808893; PubMed Central PMCID: PMC5710824. 19: Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, Nigi L, Formichi C, Mfarrej B, Petrelli A, Fousteri G, Brusko TM, Dotta F, Battaglia M. Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression. Sci Rep. 2017 Jul 31;7(1):6897. doi: 10.1038/s41598-017-07172-1. PubMed PMID: 28761107; PubMed Central PMCID: PMC5537269. 20: Zhang P, Rojas A, Blechacz B. Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation. J Vis Exp. 2017 Jun 27;(124). doi: 10.3791/55689. PubMed PMID: 28715365.