MedKoo Cat#: 563565 | Name: BAPTA-AM
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAPTA-AM is a selective, cell-permeable calcium chelator, blocking hKv1.5, hKV11.1 (hERG) and hKv1.3 channels.

Chemical Structure

BAPTA-AM
BAPTA-AM
CAS#126150-97-8

Theoretical Analysis

MedKoo Cat#: 563565

Name: BAPTA-AM

CAS#: 126150-97-8

Chemical Formula: C34H40N2O18

Exact Mass: 764.2276

Molecular Weight: 764.69

Elemental Analysis: C, 53.40; H, 5.27; N, 3.66; O, 37.66

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 550.00 4 Weeks
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Synonym
BAPTA-AM; BAPTA AM; BAPTAAM; BAPTA/AM; BAPTA Acetoxymethyl ester
IUPAC/Chemical Name
Acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
InChi Key
YJIYWYAMZFVECX-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
SMILES Code
O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 764.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rcom-H'cheo-Gauthier A, Goodwin J, Pountney DL. Interactions between calcium and alpha-synuclein in neurodegeneration. Biomolecules. 2014 Aug 14;4(3):795-811. doi: 10.3390/biom4030795. Review. PubMed PMID: 25256602; PubMed Central PMCID: PMC4192672. 2: Shirakawa H. [Pathophysiological significance of the canonical transient receptor potential (TRPC) subfamily in astrocyte activation]. Yakugaku Zasshi. 2012;132(5):587-93. Review. Japanese. PubMed PMID: 22687694. 3: Brodsky VY, Zvezdina ND. Melatonin as the most effective organizer of the rhythm of protein synthesis in hepatocytes in vitro and in vivo. Cell Biol Int. 2010 Dec;34(12):1199-204. doi: 10.1042/CBI20100036. Review. PubMed PMID: 21067519. 4: Chen B, Nicol G, Cho WK. Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line. J Membr Biol. 2007 Jan;215(1):1-13. Epub 2007 May 5. Review. PubMed PMID: 17483866. 5: Kito Y, Suzuki H. Electrophysiological properties of gastric pacemaker potentials. J Smooth Muscle Res. 2003 Oct;39(5):163-73. Review. PubMed PMID: 14695027. 6: Kuwabara M, Takahashi K, Inanami O. Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells. J Radiat Res. 2003 Sep;44(3):203-9. Review. PubMed PMID: 14646222. 7: Tymianski M, Spigelman I, Zhang L, Carlen PL, Tator CH, Charlton MP, Wallace MC. Mechanism of action and persistence of neuroprotection by cell-permeant Ca2+ chelators. J Cereb Blood Flow Metab. 1994 Nov;14(6):911-23. Review. PubMed PMID: 7929656.