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MedKoo Cat#: 598964 | Name: Sorbitan monostearate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sorbitan monostearate is an ester of sorbitan (a sorbitol derivative) and stearic acid and is sometimes referred to as a synthetic wax.

Chemical Structure

Sorbitan monostearate
Sorbitan monostearate
CAS#1338-41-6

Theoretical Analysis

MedKoo Cat#: 598964

Name: Sorbitan monostearate

CAS#: 1338-41-6

Chemical Formula: C24H46O6

Exact Mass: 430.3294

Molecular Weight: 430.62

Elemental Analysis: C, 66.94; H, 10.77; O, 22.29

Price and Availability

Size Price Availability Quantity
25g USD 200.00
500g USD 320.00
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Related CAS #
No Data
Synonym
Sorgen 50; Sorbitan monostearate; Span 55; Sorbon S 60; Emsorb 2505; Liposorb S-20; Liposorb S; Anhydrosorbitol monostearate;
IUPAC/Chemical Name
(R)-2-((2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl stearate
InChi Key
HVUMOYIDDBPOLL-XWVZOOPGSA-N
InChi Code
InChI=1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21+,23+,24+/m0/s1
SMILES Code
CCCCCCCCCCCCCCCCCC(OC[C@H]([C@H]1OC[C@@H]([C@H]1O)O)O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 430.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Poletto FS, De Oliveira CP, Wender H, Regent D, Donida B, Teixeira SR, Guterres SS, Rossi-Bergmann B, Pohlmann AR. How Sorbitan Monostearate Can Increase Drug-Loading Capacity of Lipid-Core Polymeric Nanocapsules. J Nanosci Nanotechnol. 2015 Jan;15(1):827-37. PubMed PMID: 26328447. 2: Singh VK, Pramanik K, Ray SS, Pal K. Development and characterization of sorbitan monostearate and sesame oil-based organogels for topical delivery of antimicrobials. AAPS PharmSciTech. 2015 Apr;16(2):293-305. doi: 10.1208/s12249-014-0223-7. Epub 2014 Oct 4. PubMed PMID: 25277240; PubMed Central PMCID: PMC4370955. 3: Zhao Q, Kuang W, Long Z, Fang M, Liu D, Yang B, Zhao M. Effect of sorbitan monostearate on the physical characteristics and whipping properties of whipped cream. Food Chem. 2013 Dec 1;141(3):1834-40. doi: 10.1016/j.foodchem.2013.04.086. Epub 2013 May 7. PubMed PMID: 23870898. 4: Myung Y, Yeom S, Han S. A niosomal bilayer of sorbitan monostearate in complex with flavones: a molecular dynamics simulation study. J Liposome Res. 2016 Dec;26(4):336-44. doi: 10.3109/08982104.2016.1144204. Epub 2016 Mar 16. PubMed PMID: 26982006. 5: Kamel R, Basha M, Abd El-Alim SH. Development of a novel vesicular system using a binary mixture of sorbitan monostearate and polyethylene glycol fatty acid esters for rectal delivery of rutin. J Liposome Res. 2013 Mar;23(1):28-36. doi: 10.3109/08982104.2012.727422. Epub 2012 Oct 19. PubMed PMID: 23083098. 6: Murdan S, Gregoriadis G, Florence AT. Novel sorbitan monostearate organogels. J Pharm Sci. 1999 Jun;88(6):608-14. PubMed PMID: 10350496. 7: Murdan S, Gregoriadis G, Florence AT. Inverse toroidal vesicles: precursors of tubules in sorbitan monostearate organogels. Int J Pharm. 1999 Jun 10;183(1):47-9. PubMed PMID: 10361153. 8: Murdan S, van den Bergh B, Gregoriadis G, Florence AT. Water-in-sorbitan monostearate organogels (water-in-oil gels). J Pharm Sci. 1999 Jun;88(6):615-9. PubMed PMID: 10350497. 9: Murdan S, Gregoriadis G, Florence AT. Sorbitan monostearate/polysorbate 20 organogels containing niosomes: a delivery vehicle for antigens? Eur J Pharm Sci. 1999 Jul;8(3):177-86. PubMed PMID: 10379040. 10: WALDSTEIN SS, SCHOOLMAN HM, POPPER H. The effect of feeding large amounts of emulsifiers polyoxyethylene (20) sorbitan monostearate (tween 60) and sorbitan monostearate (span 60) to humans. Am J Dig Dis. 1954 Jul;21(7):181-5. PubMed PMID: 13171357. 11: DELLA PORTA G, SHUBIK P, DAMMERT K, TERRACINI B. Role of polyoxyethylene sorbitan monostearate in skin carcinogenesis in mice. J Natl Cancer Inst. 1960 Sep;25:607-25. PubMed PMID: 13721614. 12: Brandner JD. The composition of NF-defined emulsifiers: sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80. Drug Dev Ind Pharm. 1998 Nov;24(11):1049-54. PubMed PMID: 9876559. 13: Uchegbu IF, Double JA, Turton JA, Florence AT. Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse. Pharm Res. 1995 Jul;12(7):1019-24. PubMed PMID: 7494796. 14: Magill A, Becker AR. Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate. J Pharm Sci. 1984 Nov;73(11):1663-4. PubMed PMID: 6520780. 15: DAMMERT K. The effect of five ulcerating doses of alkyldimethylbenzylammoniumchloride (Zephiran) on the tumor promoting action of polyoxyethylene sorbitan monostearate (tween 60). An analysis of the dermal condition in tumor promotion. Acta Pathol Microbiol Scand. 1961;53:22-32. PubMed PMID: 13883317. 16: SHUBIK P, DELLA PORTA G, SPENCER K. Studies of the action of polyoxyethylene sorbitan monostearate (tween 60) in skin carcinogenesis in the mouse. Acta Unio Int Contra Cancrum. 1959;15(1):232-41. PubMed PMID: 13649458. 17: Shan L. Perfluoropropane-filled, sorbitan monostearate– and polyoxyethylene 40 stearate–shelled nanobubbles. 2010 Aug 2 [updated 2010 Sep 1]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK45631/ PubMed PMID: 20827822. 18: Korhonen M, Hirvonen J, Peltonen L, Antikainen O, Yrjänäinen L, Yliruusi J. Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams. Int J Pharm. 2004 Jan 9;269(1):227-39. PubMed PMID: 14698594. 19: Hendy RJ, Butterworth KR, Gaunt IF, Kiss IS, Grasso P. Long-term toxicity study of sorbitan monostearate (Span 60) in mice. Food Cosmet Toxicol. 1978 Dec;16(6):527-34. PubMed PMID: 730079. 20: Sato J, Hara I. [Interaction between C-reactive protein and sorbitan monostearate]. Seikagaku. 1969 Jan;41(1):7-10. Japanese. PubMed PMID: 5813947.