Synonym
Dienestrol diacetate; Cycladiene; Retalon-oral; Oestrasid C; NSC 59809; NSC59809; NSC-59809;
IUPAC/Chemical Name
((2E,4E)-hexa-2,4-diene-3,4-diyl)bis(4,1-phenylene) diacetate
InChi Key
YWLLGDVBTLPARJ-OXAZHYLESA-N
InChi Code
InChI=1S/C22H22O4/c1-5-21(17-7-11-19(12-8-17)25-15(3)23)22(6-2)18-9-13-20(14-10-18)26-16(4)24/h5-14H,1-4H3/b21-5+,22-6+
SMILES Code
C/C=C(C1=CC=C(OC(C)=O)C=C1)/C(C2=CC=C(OC(C)=O)C=C2)=C/C
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
350.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: JONES JE, WILSON HR, WALDROUP PW, HARMS RH. EFFECTS OF DOSAGE LEVEL AND LENGTH OF FEEDING DIENESTROL DIACETATE ON POTENTIATION OF OXYTETRACYCLINE. Poult Sci. 1965 Mar;44:486-8. PubMed PMID: 14340738.
2: POCKRANDT H. [Effects of dienestrol diacetate, a synthetic estrogen, on skin in percutaneous administration]. Z Geburtshilfe Gynakol. 1954;141(1):85-97. German. PubMed PMID: 13196430.
3: MRAZ F, LENOIR M, PINAJIAN J, PATRICK H. Influence of parathyroid extract, cortisone and dienestrol diacetate on metabolism of cesium in rats. Arch Biochem Biophys. 1956 Jul;63(1):73-6. PubMed PMID: 13341044.
4: VON BERSWORDT-WALLRABE R. [Study of a theoretical explanation of the inhibition of milk production in albino mice by dienestrol diacetate]. Arch Gynakol. 1958;190(6):619-37. German. PubMed PMID: 13595687.
5: VON BERSWORDT-WALLRABE R. [Inhibition of milk production in albino mice by dienestrol diacetate and its effects on the incretory system]. Arch Gynakol. 1958;190(6):549-618. German. PubMed PMID: 13595686.
6: HOHLWEG W, DAUME E. [On the effect of intracerebrally administered dienestrol diacetate in rats]. Endokrinologie. 1959 Jul;38:46-51. German. PubMed PMID: 14402509.
7: TRIMBORN J, WERLE E, SEMM K. [Experimental and clinical examination of dienestrol diacetate]. Dtsch Med Wochenschr. 1950 Dec 8;75(49):1661-3. Undetermined Language. PubMed PMID: 14793208.
8: Roberson RH, Trujillo T. The effect of methionine, thiouracil, dienestrol diacetate and thyroprotein on the development and prevention of fatty liver in pullets. Poult Sci. 1975 May;54(3):715-21. PubMed PMID: 1153373.
9: Rowland LO Jr, Harms RH. Influence of protamone and dienestrol diacetate on bone fragility of caged layers. Poult Sci. 1970 Jan;49(1):128-31. PubMed PMID: 5440069.
10: Simpson CF, Harms RH. Aortic ruptures in turkeys induced by diethylstilbestrol and dienestrol diacetate. Proc Soc Exp Biol Med. 1966 Nov;123(2):604-6. PubMed PMID: 5924508.
11: Duby RT, Travis HF. Influence of dienestrol diacetate on reproductive performance of female mink (Mustela vision). Am J Vet Res. 1971 Oct;32(10):1599-602. PubMed PMID: 5115545.
12: Douglas CR, Harms RH, Carpenter MD, Chaille TB. Performance of Leghorn type hens fed two levels of energy and a synthetic estrogen during the growing period. Poult Sci. 1989 Jun;68(6):825-9. PubMed PMID: 2771848.
13: Takahashi K, Jensen LS. Reduction in hepatic lipid and plasma estradiol in estrogenized chicks injected with ascorbic acid. Proc Soc Exp Biol Med. 1985 Feb;178(2):200-3. PubMed PMID: 3969379.
14: Akiba Y, Takahashi K, Kimura M, Hirama SI, Matsumoto T. The influence of environmental temperature, thyroid status and a synthetic oestrogen on the induction of fatty livers in chicks. Br Poult Sci. 1983 Jan;24(1):71-80. PubMed PMID: 6831278.
15: Jain AV, Schall ED. Gas-liquid chromatographic determination of diethylstilbestrol in molasses-based liquid feed supplements. J Assoc Off Anal Chem. 1975 Jul;58(4):818-21. PubMed PMID: 238933.
16: Schade R, Bürger W. Hormonal regulation of a new female-specific serum protein (FP) of the laboratory rat. Experientia. 1982 Apr 15;38(4):509-11. PubMed PMID: 7084425.
17: Akiba Y, Takahashi K, Matsumoto T. Effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate on experimental fatty livers in chicks. Poult Sci. 1984 Jan;63(1):117-22. PubMed PMID: 6701137.
