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MedKoo Cat#: 563551 | Name: Armillarisin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Armillarisin A is a regulator and promotor of immune functions. It acts by enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function.

Chemical Structure

Armillarisin A
CAS#53696-74-5

Theoretical Analysis

MedKoo Cat#: 563551

Name: Armillarisin A

CAS#: 53696-74-5

Chemical Formula: C12H10O5

Exact Mass: 234.0528

Molecular Weight: 234.20

Elemental Analysis: C, 61.54; H, 4.30; O, 34.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Armillarisin A; Armillarisin-A;
IUPAC/Chemical Name
3-Acetyl-7-hydroxy-5-(hydroxymethyl)-2H-chromen-2-one
InChi Key
XVZWWNMZVZWQKU-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10O5/c1-6(14)9-4-10-7(5-13)2-8(15)3-11(10)17-12(9)16/h2-4,13,15H,5H2,1H3
SMILES Code
O=C1C(C(C)=O)=CC2=C(O1)C=C(O)C=C2CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 234.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fei Y, Li WQ, Zong GQ, Chen J, Wang W. Cholecystolithotomy Combined Armillarisin A versus Cholecystectomy in Cirrhotic Portal Hypertension Patients with Symptomatic Cholelithiasis. Chirurgia (Bucur). 2017 Mar-Apr;112(2):143-151. doi: 10.21614/chirurgia.112.2.143. PubMed PMID: 28463673. 2: Wu P, Guo Y, Jia F, Wang X. The Effects of Armillarisin A on Serum IL-1β and IL-4 and in Treating Ulcerative Colitis. Cell Biochem Biophys. 2015 May;72(1):103-6. doi: 10.1007/s12013-014-0413-7. PubMed PMID: 25420534; PubMed Central PMCID: PMC4457911. 3: Sun D, Zhu L, Xiao L, Xia Y, Ge G, Cao Y, Wu Y, Yin J, Yang L. In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica. 2014 Nov;44(11):988-95. doi: 10.3109/00498254.2014.927084. Epub 2014 Jun 11. PubMed PMID: 24916899. 4: Chen Q, Li P, Zhang J, Zhu J. Preclinical pharmacokinetic analysis of armillarisin succinate ester in mouse plasma and tissues by LC-MS/MS. Biomed Chromatogr. 2013 Jan;27(1):130-6. doi: 10.1002/bmc.2762. Epub 2012 Jun 5. PubMed PMID: 22674750. 5: Chen Q, Li P, Li B, Yuan F, Li X, Zhu J. Development of a method for comprehensive and quantitative analysis of armillarisin succinate ester in its medicinal preparations by liquid chromatography-ion trap mass spectrometry. Pharmazie. 2011 Sep;66(9):648-53. PubMed PMID: 22026118. 6: Shen JW, Ma BJ, Li W, Yu HY, Wu TT, Ruan Y. Activity of armillarisin B in vitro against plant pathogenic fungi. Z Naturforsch C. 2009 Nov-Dec;64(11-12):790-2. PubMed PMID: 20158147. 7: Luo MY, Lin BL, Gao ZL. Clinical features, laboratory findings and imaging appearances of venous diethylene glycol poisoning in patients with liver disease. Chin Med J (Engl). 2009 Oct 5;122(19):2315-20. PubMed PMID: 20079132. 8: Peng XM, Huang MX, Gu L, Lin BL, Chen GH. Characteristics of patients with liver disease intravenously exposed to diethylene glycol in China 2006. Clin Toxicol (Phila). 2009 Feb;47(2):124-31. doi: 10.1080/15563650802245489. PubMed PMID: 18792827. 9: Lin BL, Zhao ZX, Chong YT, Li JG, Zuo X, Tao Y, Lou TQ, Gao ZL. Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China. World J Gastroenterol. 2008 May 28;14(20):3236-41. PubMed PMID: 18506932; PubMed Central PMCID: PMC2712859. 10: Yao J, Gu XT, Zhou JP, Ping QN, Lu Y. [Distribution behavior of lipophilic drugs in the oil-in-water microemulsions]. Yao Xue Xue Bao. 2007 Jul;42(7):768-73. Chinese. PubMed PMID: 17882963. 11: Zhou T, Zhang H, Duan G. Simultaneous determination of diethylene glycol and propylene glycol in pharmaceutical products by HPLC after precolumn derivatization with p-toluenesulfonyl isocyanate. J Sep Sci. 2007 Nov;30(16):2620-7. PubMed PMID: 17880028. 12: Wang Y, Wang Y, Li P, Tang Y, Fawcett JP, Gu J. Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43(5):1860-3. Epub 2007 Jan 23. PubMed PMID: 17250987. 13: Zhu JB, Luan LB, Shi QC. [Development of rapid-dissolution armillarisin-A tablet and study on its choleretic action in rats]. Yao Xue Xue Bao. 1992;27(3):231-5. Chinese. PubMed PMID: 1414391. 14: Sun F, Su JD, Zheng H. [Studies on the pharmacological activities and toxicities of armillarisin A, a new choleretic drug (author's transl)]. Yao Xue Xue Bao. 1981 Jun;16(6):401-6. Chinese. PubMed PMID: 7270166. 15: Yuan XB. [A method for the determination or armillarisin A (author's transl)]. Yao Xue Xue Bao. 1981 Apr;16(4):313-6. Chinese. PubMed PMID: 7257819. 16: Shao HS, Zhang SR, Pan SR, Jing XN, Ying LQ, Zhu HY. [Absorption, distribution, excretion and metabolites of [14C]armillarisin A in rats (author's transl)]. Zhongguo Yao Li Xue Bao. 1980 Dec;1(2):120-4. Chinese. PubMed PMID: 6461183. 17: [Studies on the synthesis Armillarisin A (author's transl)]. Yao Xue Xue Bao. 1979;14(9):525-8. Chinese. PubMed PMID: 532654.

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