Amitriptylinoxide | CAS#4317-14-0 | Antidepressive

MedKoo Cat#: 592771 | Name: Amitriptylinoxide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amitriptylinoxide, an active metabolite of amitriptyline, is a tricyclic antidepressant (TCA) with pharmacological properties similar to its parent compound. It primarily acts by inhibiting the reuptake of serotonin and norepinephrine, increasing their synaptic concentrations and enhancing neurotransmission. Studies indicate that amitriptylinoxide retains strong affinity for serotonin transporter (SERT) and norepinephrine transporter (NET), with reported IC₅₀ values in the nanomolar range, similar to amitriptyline. It also exhibits antagonist activity at histaminergic (H1), muscarinic (M1), and α-adrenergic receptors, contributing to its sedative and autonomic side effects. Compared to amitriptyline, amitriptylinoxide has faster onset, reduced first-pass metabolism, and improved tolerability, leading to its clinical use in some regions as a better-tolerated alternative for depression and neuropathic pain.

Chemical Structure

Amitriptylinoxide

CAS#4317-14-0

Theoretical Analysis

MedKoo Cat#: 592771

Name: Amitriptylinoxide

CAS#: 4317-14-0

Chemical Formula: C20H23NO

Exact Mass: 293.1780

Molecular Weight: 293.41

Elemental Analysis: C, 81.87; H, 7.90; N, 4.77; O, 5.45

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 350.00	2 Weeks
250mg	USD 950.00	2 Weeks

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Related CAS #

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Synonym

Amitriptylinoxide

IUPAC/Chemical Name

10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine N-oxide

InChi Key

ZPMKQFOGINQDAM-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

SMILES Code

C[N+](CC/C=C1C2=C(CCC3=C\1C=CC=C3)C=CC=C2)([O-])C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 293.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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