MedKoo Cat#: 461519 | Name: RU 33965

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RU 33965 is a 3-cyclopropyl carbonyl imidazobenzodiazepine that act as a low-efficacy benzodiazepine receptor inverse agonist.

Chemical Structure

RU 33965
RU 33965
CAS#122321-05-5

Theoretical Analysis

MedKoo Cat#: 461519

Name: RU 33965

CAS#: 122321-05-5

Chemical Formula: C16H15N3O2

Exact Mass: 281.1164

Molecular Weight: 281.31

Elemental Analysis: C, 68.31; H, 5.37; N, 14.94; O, 11.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RU 33965; RU-33965; RU33965;
IUPAC/Chemical Name
3-(cyclopropanecarbonyl)-5-methyl-4,5-dihydro-6H-benzo[f]imidazo[1,5-a][1,4]diazepin-6-one
InChi Key
KNOYNQIVNYWKJR-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15N3O2/c1-18-8-13-14(15(20)10-6-7-10)17-9-19(13)12-5-3-2-4-11(12)16(18)21/h2-5,9-10H,6-8H2,1H3
SMILES Code
O=C1N(C)CC2=C(C(C3CC3)=O)N=CN2C4=CC=CC=C14
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gardner CR, Budhram P, Parker FL. Discriminative stimulus properties of RU 33965, a benzodiazepine receptor weak partial inverse agonist. Pharmacol Biochem Behav. 1992 Oct;43(2):583-8. PubMed PMID: 1359581. 2: Ward RA, Gardner CR, Pringle A, Bagust J, Walker RJ. The effects of RU 33965 and RU 34030, two new 3-cyclopropyl carbonyl imidazobenzodiazepines, on GABAA receptor-mediated synaptic transmission in cerebellar slices in the rat. Gen Pharmacol. 1994 May;25(3):589-97. PubMed PMID: 7926610. 3: Turchi J, Holley LA, Sarter M. Effects of benzodiazepine receptor inverse agonists and nicotine on behavioral vigilance in senescent rats. J Gerontol A Biol Sci Med Sci. 1996 May;51(3):B225-31. PubMed PMID: 8630700. 4: McGaughy J, Sarter M. Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. Psychopharmacology (Berl). 1995 Feb;117(3):340-57. PubMed PMID: 7770610.