MedKoo Cat#: 598918 | Name: Linderalactone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Linderalactone is an NSAID isolated from Lindera aggregata.

Chemical Structure

Linderalactone
Linderalactone
CAS#728-61-0

Theoretical Analysis

MedKoo Cat#: 598918

Name: Linderalactone

CAS#: 728-61-0

Chemical Formula: C15H16O3

Exact Mass: 244.1099

Molecular Weight: 244.29

Elemental Analysis: C, 73.75; H, 6.60; O, 19.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Linderalactone;
IUPAC/Chemical Name
(R,7Z,10E)-3,11-dimethyl-4,8,9,12-tetrahydro-6H-4,7-(metheno)furo[3,2-c][1]oxacycloundecin-6-one
InChi Key
LWCKQMHMTSRRAA-QGQQYVBWSA-N
InChi Code
InChI=1S/C15H16O3/c1-9-4-3-5-11-7-13(18-15(11)16)14-10(2)8-17-12(14)6-9/h4,7-8,13H,3,5-6H2,1-2H3/b9-4+/t13-/m1/s1
SMILES Code
O=C1C2=C[C@@](C3=C(OC=C3C)C/C(C)=C/CC2)([H])O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gan LS, Zheng YL, Mo JX, Liu X, Li XH, Zhou CX. Sesquiterpene lactones from the root tubers of Lindera aggregata. J Nat Prod. 2009 Aug;72(8):1497-501. doi: 10.1021/np900354q. PubMed PMID: 19639966. 2: Yen MC, Shih YC, Hsu YL, Lin ES, Lin YS, Tsai EM, Ho YW, Hou MF, Kuo PL. Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast cancer. Oncol Rep. 2016 Mar;35(3):1356-64. doi: 10.3892/or.2015.4503. Epub 2015 Dec 22. PubMed PMID: 26707189. 3: Zhang CF, Sun QS, Wang ZT, Chou GX. [Studies on constituents of the leaves of Lindera aggregata (Sims) Kosterm]. Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):765-7. Chinese. PubMed PMID: 12776349. 4: Chang WA, Lin ES, Tsai MJ, Huang MS, Kuo PL. Isolinderalactone inhibits proliferation of A549 human non small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Mol Med Rep. 2014 May;9(5):1653-9. doi: 10.3892/mmr.2014.2015. Epub 2014 Mar 6. PubMed PMID: 24604009. 5: Kobayashi W, Miyase T, Sano M, Umehara K, Warashina T, Noguchi H. Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill. Biol Pharm Bull. 2002 Aug;25(8):1049-52. PubMed PMID: 12186408. 6: Cheng XL, Ma SC, Wei F, Wang GL, Xiao XY, Lin RC. A new sesquiterpene isolated from Lindera aggregata (SIMS) KOSTERM. Chem Pharm Bull (Tokyo). 2007 Sep;55(9):1390-2. PubMed PMID: 17827769. 7: Chen KS, Hsieh PW, Hwang TL, Chang FR, Wu YC. Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma. Nat Prod Res. 2005 Apr;19(3):283-6. PubMed PMID: 15702642.