Lincomycin-B | CAS#2520-24-3 | lincosamide antibiotic

MedKoo Cat#: 598913 | Name: Lincomycin-B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lincomycin-B is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis.

Chemical Structure

Lincomycin-B

CAS#2520-24-3

Theoretical Analysis

MedKoo Cat#: 598913

Name: Lincomycin-B

CAS#: 2520-24-3

Chemical Formula: C17H32N2O6S

Exact Mass: 392.1981

Molecular Weight: 392.51

Elemental Analysis: C, 52.02; H, 8.22; N, 7.14; O, 24.46; S, 8.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Lincomycin-B; U 21699; U-21699; U21699; Antibiotic U 21699;

IUPAC/Chemical Name

(2S,4R)-4-ethyl-N-((1R,2R)-2-hydroxy-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methylpyrrolidine-2-carboxamide

InChi Key

DZSDDKNXMARQMJ-NUFQGRFVSA-N

InChi Code

InChI=1S/C17H32N2O6S/c1-5-9-6-10(19(3)7-9)16(24)18-11(8(2)20)15-13(22)12(21)14(23)17(25-15)26-4/h8-15,17,20-23H,5-7H2,1-4H3,(H,18,24)/t8-,9-,10+,11-,12+,13-,14-,15+,17-/m1/s1

SMILES Code

CC[C@@H]1C[C@@H](C(N[C@H]([C@H](O)C)[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O2)=O)N(C)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 392.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pang AP, Du L, Lin CY, Qiao J, Zhao GR. Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis. J Appl Microbiol. 2015 Oct;119(4):1064-74. doi: 10.1111/jam.12919. PubMed PMID: 26248490. 2: Wang M, Cai C, Zhang B, Liu H. Characterization and mechanism analysis of lincomycin biodegradation with Clostridium sp. strain LCM-B isolated from lincomycin mycelial residue (LMR). Chemosphere. 2018 Feb;193:611-617. doi: 10.1016/j.chemosphere.2017.11.055. Epub 2017 Nov 13. PubMed PMID: 29169137. 3: McMurray CH, Blanchflower WJ, Rice DA. Gas chromatographic-mass spectrometric detection and quantitation of lincomycin in animal feedingstuffs. J Assoc Off Anal Chem. 1984 May-Jun;67(3):582-8. PubMed PMID: 6547713. 4: Orwa JA, Vandenbempt K, Depuydt S, Roets E, Hoogmartens J. Liquid chromatography method for separation of clindamycin from related substances. J Pharm Biomed Anal. 1999 Sep;20(5):745-52. PubMed PMID: 10701982.