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MedKoo Cat#: 598884 | Name: LiLo

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LiLo is a chelating agent for attaching indium-111 to monoclonal antibodies.

Chemical Structure

LiLo
LiLo
CAS#134439-56-8

Theoretical Analysis

MedKoo Cat#: 598884

Name: LiLo

CAS#: 134439-56-8

Chemical Formula: C39H57N9O18S

Exact Mass: 971.3542

Molecular Weight: 971.99

Elemental Analysis: C, 48.19; H, 5.91; N, 12.97; O, 29.63; S, 3.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LiLo;
IUPAC/Chemical Name
3,6,9,19,22,25-hexakis(carboxymethyl)-14-(4-isothiocyanatobenzyl)-11,17-dioxo-3,6,9,12,16,19,22,25-octaazaheptacosanedioic acid
InChi Key
OWFPZFPOOSUIIA-UHFFFAOYSA-N
InChi Code
InChI=1S/C39H57N9O18S/c49-30(16-45(20-34(55)56)9-5-43(18-32(51)52)7-11-47(22-36(59)60)23-37(61)62)40-14-28(13-27-1-3-29(4-2-27)42-26-67)15-41-31(50)17-46(21-35(57)58)10-6-44(19-33(53)54)8-12-48(24-38(63)64)25-39(65)66/h1-4,28H,5-25H2,(H,40,49)(H,41,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)(H,63,64)(H,65,66)
SMILES Code
O=C(O)CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(NCC(CC1=CC=C(N=C=S)C=C1)CNC(CN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 971.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rzesnitzek L. ["Psychological employees" in psychiatry. The establishment of clinical psychology at the example of Lilo Süllwolds diagnostic efforts to incipient schizophrenia]. Medizinhist J. 2015;50(4):357-92. German. PubMed PMID: 26821495. 2: Jikia D. Long-term follow-up of the patients injured in the Lilo Radiological Accident. Health Phys. 2010 Jun;98(6):872-5. doi: 10.1097/HP.0b013e3181c8f949. PubMed PMID: 20445397. 3: Scherthan H, Abend M, Müller K, Beinke C, Braselmann H, Zitzelsberger H, Köhn FM, Pillekamp H, Schiener R, Das O, Peter RU, Herzog G, Tzschach A, Dörr HD, Fliedner TM, Meineke V. Radiation-induced late effects in two affected individuals of the Lilo radiation accident. Radiat Res. 2007 May;167(5):615-23. PubMed PMID: 17474790. 4: Pillai PK, Shriver EL. Photoinduced polarization properties of LilO(3) single crystal. Appl Opt. 1975 Dec 1;14(12):2978-82. doi: 10.1364/AO.14.002978. PubMed PMID: 20155141. 5: Oyen WJ, Boerman OC, Subramanian R, Koenders EB, Claessens RA, van der Meer JW, Corstens FH. Biodistribution of 111In-labelled IgG and IgM in experimental infection. Nucl Med Commun. 1996 Jul;17(7):616-20. PubMed PMID: 8843122. 6: Subramanian R, Colony J, Shaban S, Sidrak H, Haspel MV, Pomato N, Hanna MG Jr, McCabe RP. New chelating agent for attaching indium-111 to monoclonal antibodies: in vitro and in vivo evaluation. Bioconjug Chem. 1992 May-Jun;3(3):248-55. PubMed PMID: 1520729. 7: Roy L, Gregoire E, Durand V, Buard V, Delbos M, Paillole N, Sorokine-Durm I, Gourmelon P, Voisin P. Study of the tools available in biological dosimetry to estimate the dose in cases of accidental complex overexposure to ionizing radiation: the Lilo accident. Int J Radiat Biol. 2006 Jan;82(1):39-48. PubMed PMID: 16546902. 8: Mettler L. Specialist life--Lilo Mettler. Eur J Obstet Gynecol Reprod Biol. 2005 Feb 1;118(2):275-6. PubMed PMID: 15653223. 9: Goldberg LS. Narrow-Bandwidth Tunable Infrared Difference-Frequency Generation at High Repetition Rates in LilO(3). Appl Opt. 1975 Mar 1;14(3):653-6. doi: 10.1364/AO.14.000653. PubMed PMID: 20134947. 10: Khalifian S, Ibrahim Z, Lilo MT, Milner SM. Toxic epidermal necrolysis. Eplasty. 2014 Mar 15;14:ic6. eCollection 2014. PubMed PMID: 24741389; PubMed Central PMCID: PMC3962031. 11: Desemo U, Kappeler F, Hanke C. Coherent 440-nm light source by optical frequency doubling of the radiation of a phase-locked high power laser array using LilO(3). Appl Opt. 1987 Apr 15;26(8):1367-8. doi: 10.1364/AO.26.001367. PubMed PMID: 20454325. 12: Lilo MT, Allison D, Wang Y, Ao M, Gabrielson E, Geddes S, Zhang H, Askin F, Li QK. Expression of P40 and P63 in lung cancers using fine needle aspiration cases. Understanding clinical pitfalls and limitations. J Am Soc Cytopathol. 2016 May-Jun;5(3):123-132. PubMed PMID: 27699149; PubMed Central PMCID: PMC5044754. 13: Meineke V, van Beuningen D, Sohns T, Fliedner TM. Medical management principles for radiation accidents. Mil Med. 2003 Mar;168(3):219-22. Review. PubMed PMID: 12685687. 14: de la Rosa IA, Barnett-Queen T, Messick M, Gurrola M. Spirituality and Resilience Among Mexican American IPV Survivors. J Interpers Violence. 2016 Dec;31(20):3332-3351. Epub 2015 May 6. PubMed PMID: 25948642. 15: Glassberg MK, Catanuto P, Shahzeidi S, Aliniazee M, Lilo S, Rubio GA, Elliot SJ. Estrogen deficiency promotes cigarette smoke-induced changes in the extracellular matrix in the lungs of aging female mice. Transl Res. 2016 Dec;178:107-117. doi: 10.1016/j.trsl.2016.07.015. Epub 2016 Jul 25. PubMed PMID: 27519148. 16: Elhaik Goldman S, Dotan S, Talias A, Lilo A, Azriel S, Malka I, Portnoi M, Ohayon A, Kafka D, Ellis R, Elkabets M, Porgador A, Levin D, Azhari R, Swiatlo E, Ling E, Feldman G, Tal M, Dagan R, Mizrachi Nebenzahl Y. Streptococcus pneumoniae fructose-1,6-bisphosphate aldolase, a protein vaccine candidate, elicits Th1/Th2/Th17-type cytokine responses in mice. Int J Mol Med. 2016 Apr;37(4):1127-38. doi: 10.3892/ijmm.2016.2512. Epub 2016 Mar 1. PubMed PMID: 26935978. 17: Horwitz SM, Storfer-Isser A, Kerker BD, Lilo E, Leibovitz A, St John N, Shaw RJ. A model for the development of mothers' perceived vulnerability of preterm infants. J Dev Behav Pediatr. 2015 Jun;36(5):371-80. doi: 10.1097/DBP.0000000000000173. PubMed PMID: 25961903; PubMed Central PMCID: PMC4456223. 18: Horwitz SM, Leibovitz A, Lilo E, Jo B, Debattista A, St John N, Shaw RJ. Does an intervention to reduce maternal anxiety, depression and trauma also improve mothers' perceptions of their preterm infants' vulnerability? Infant Ment Health J. 2015 Jan-Feb;36(1):42-52. doi: 10.1002/imhj.21484. Epub 2014 Dec 1. Erratum in: Infant Ment Health J. 2015 May-Jun;36(3):352. PubMed PMID: 25452159; PubMed Central PMCID: PMC4413008. 19: Allison DB, Olson MT, Lilo M, Zhang ML, Rosenthal DL, VandenBussche CJ. Should the BK polyomavirus cytopathic effect be best classified as atypical or benign in urine cytology specimens? Cancer Cytopathol. 2016 Jun;124(6):436-42. doi: 10.1002/cncy.21705. Epub 2016 Feb 29. PubMed PMID: 26929126. 20: Klein GM, Nasser AE, Phillips BT, Gersch RP, Fourman MS, Lilo SE, Fritz JR, Khan SU, Dagum AB, Bui DT. Is Sterile Better Than Aseptic? Comparing the Microbiology of Acellular Dermal Matrices. Plast Reconstr Surg Glob Open. 2016 Jun 28;4(6):e761. doi: 10.1097/GOX.0000000000000705. eCollection 2016 Jun. PubMed PMID: 27482500; PubMed Central PMCID: PMC4956873.

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LIMK-IN-14

LIMK-IN-14