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MedKoo Cat#: 598869 | Name: Lilly 18947

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lilly 18947 is an inhibitor of cytochrome P450.

Chemical Structure

Lilly 18947
Lilly 18947
CAS#2600-77-3

Theoretical Analysis

MedKoo Cat#: 598869

Name: Lilly 18947

CAS#: 2600-77-3

Chemical Formula: C18H21Cl2NO

Exact Mass: 337.1000

Molecular Weight: 338.27

Elemental Analysis: C, 63.91; H, 6.26; Cl, 20.96; N, 4.14; O, 4.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Lilly 18947; Lilly-18947; Lilly18947; LY 18947 (for hydrobromide);
IUPAC/Chemical Name
2-((3,5-dichloro-[1,1'-biphenyl]-2-yl)oxy)-N,N-diethylethan-1-amine
InChi Key
KXSPENPMFKDOFS-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21Cl2NO/c1-3-21(4-2)10-11-22-18-16(12-15(19)13-17(18)20)14-8-6-5-7-9-14/h5-9,12-13H,3-4,10-11H2,1-2H3
SMILES Code
CCN(CCOC1=C(C2=CC=CC=C2)C=C(Cl)C=C1Cl)CC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bernacchi AS, Franke De Cazzulo B, Castro JA. Trypanocidal action of 2,4-dichloro-6-phenylphenoxyethyl diethylamine hydrobromide (Lilly 18947) on Trypanosoma cruzi. Acta Pharmacol Sin. 2002 May;23(5):399-404. PubMed PMID: 11978189. 2: KATO R, CHIESARA E, VASSANELLI R. Stimulating effect of some inhibitors of the drug metabolisms (SKF 525 A, Lilly 18947, Lilly 32391 and MG 3062) on excretion of ascorbic acid and drug metabolisms. Med Exp Int J Exp Med. 1962;6:254-60. PubMed PMID: 14454286. 3: Carlson GP. Epinephrine-induced cardiac arrhythmias in rabbits exposed to tetrachloroethylene. Toxicol Lett. 1983 Oct-Nov;19(1-2):113-7. PubMed PMID: 6658816. 4: Carlson GP. Effect of alterations in drug metabolism on epinephrine-induced cardiac arrhythmias in rabbits exposed to methylchloroform. Toxicol Lett. 1981 Dec;9(4):307-13. PubMed PMID: 7330895. 5: Carlson GP. Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits. Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):349-52. PubMed PMID: 7302382.

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