RS 2135 | CAS#133775-36-7 | antiarrhythmic agent

MedKoo Cat#: 461489 | Name: RS 2135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS 2135 is a novel class I antiarrhythmic agent to suppress ischemia-induced ventricular arrhythmias.

Chemical Structure

RS 2135

CAS#133775-36-7

Theoretical Analysis

MedKoo Cat#: 461489

Name: RS 2135

CAS#: 133775-36-7

Chemical Formula: C18H21ClN2O2

Exact Mass: 332.1292

Molecular Weight: 332.82

Elemental Analysis: C, 64.96; H, 6.36; Cl, 10.65; N, 8.42; O, 9.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RS 2135; RS-2135; RS2135;

IUPAC/Chemical Name

(3aR,3a1S,12R,12aR)-12-amino-10-hydroxy-2,3,3a,3a1,4,11,12,12a-octahydroisoquinolino[2,1,8-lma]carbazol-5(1H)-one hydrochloride

InChi Key

MTSROZWZVOQAQW-PECACPRSSA-N

InChi Code

InChI=1S/C18H20N2O2.ClH/c19-12-8-11-17-13(5-2-6-14(17)21)20-15(22)7-9-3-1-4-10(12)16(9)18(11)20;/h2,5-6,9-10,12,16,21H,1,3-4,7-8,19H2;1H/t9-,10+,12-,16+;/m1./s1

SMILES Code

O=C1C[C@@]2([H])CCC[C@]3([H])[C@@]2([H])C(N1C4=C5C(O)=CC=C4)=C5C[C@H]3N.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 332.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yorikane R, Sada T, Koike H. Electrophysiologic effects of RS-2135, a new antiarrhythmic compound, on canine Purkinje fibers. J Cardiovasc Pharmacol. 1992 Dec;20(6):955-60. PubMed PMID: 1282599. 2: Yorikane R, Mizuno H, Itoh Y, Miyake S, Koike H. Effects of RS-2135, a novel class I antiarrhythmic agent, on sustained ventricular tachycardia after coronary embolization in conscious dogs. J Cardiovasc Pharmacol. 1994 Jul;24(1):28-36. PubMed PMID: 7521486. 3: Yorikane R, Sada T, Koike H. Effects of RS-2135, a new antiarrhythmic agent, on the kinetics of use-dependent decrease in maximum upstroke velocity in guinea pig ventricular myocardium. J Cardiovasc Pharmacol. 1993 Mar;21(3):430-4. PubMed PMID: 7681504. 4: Ito K, Nagafuchi K, Taga A, Yorikane R, Koike H. Possible involvement of altered Na+ -Ca2+ exchange in negative inotropic effects of class I antiarrhythmic drugs on rabbit and rat ventricles. J Cardiovasc Pharmacol. 1996 Mar;27(3):355-61. PubMed PMID: 8907796. 5: Yorikane R, Mizuno H, Itoh Y, Koike H, Miyake S, Shiga H, Kumakura S, Fukami M, Shimoji Y, Hashimoto T, et al. Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate. Arzneimittelforschung. 1991 Nov;41(11):1130-6. PubMed PMID: 1810258. 6: Shimoji Y, Tomita K, Hashimoto T, Saito F, Morisawa Y, Mizuno H, Yorikane R, Koike H. Synthesis and biological action of the aminotetrahydroisoquinocarbazoles and related compounds: a new class of compounds with antiarrhythmic activity. J Med Chem. 1992 Mar 6;35(5):816-22. PubMed PMID: 1548673. 7: Bajtos B, Pagenkopf BL. Synthesis of tetrahydroisoquinocarbazoles via C-2 alkylation of indoles with 2-alkoxycyclopropanoate esters. Org Lett. 2009 Jul 2;11(13):2780-3. doi: 10.1021/ol900937f. PubMed PMID: 19507849.