MedKoo Cat#: 563534 | Name: TC-G 1005
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-G 1005 is a potent and selective TGR5 (GPBAR1) agonist.

Chemical Structure

TC-G 1005
TC-G 1005
CAS#1415407-60-1

Theoretical Analysis

MedKoo Cat#: 563534

Name: TC-G 1005

CAS#: 1415407-60-1

Chemical Formula: C25H25N3O2

Exact Mass: 399.1947

Molecular Weight: 399.49

Elemental Analysis: C, 75.16; H, 6.31; N, 10.52; O, 8.01

Price and Availability

Size Price Availability Quantity
10mg USD 410.00 2 Weeks
50mg USD 1,405.00 2 Weeks
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Synonym
TC-G 1005; TC G 1005; TCG 1005; TC-G-1005; TCG1005;
IUPAC/Chemical Name
(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
InChi Key
JQULIQJSYPZQMA-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H25N3O2/c1-17-7-8-18(2)24(15-17)30-23-11-12-26-16-20(23)25(29)28-14-13-27(19-9-10-19)21-5-3-4-6-22(21)28/h3-8,11-12,15-16,19H,9-10,13-14H2,1-2H3
SMILES Code
(4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 399.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Duan H, Ning M, Chen X, Zou Q, Zhang L, Feng Y, Zhang L, Leng Y, Shen J. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. doi: 10.1021/jm301071h. Epub 2012 Nov 29. PubMed PMID: 23148522. 2: Urso A, D'Ovidio F, Xu D, Emala CW Sr, Bunnett NW, Perez-Zoghbi JF. Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L264-L275. doi: 10.1152/ajplung.00242.2019. Epub 2019 Dec 4. PMID: 31800261; PMCID: PMC7474253.